Question 1

Which of the following is not involved in "contact activation"?

Accepted Answer

A)  Factor XII 
B)  Factor XI 
C)  PK 
D)  Factor X 
A)  Factor XII 
B)  Factor XI 
C)  PK 
D)  Factor X D

Question 2

How do the following systems contribute to coagulation?
a. Complement
b. Fibrinolysis
c. Kinin

Accepted Answer

a. Complement: Plasmin activates complement by cleaving C3 into C3a and C3b.
b. Fibrinolysis: Digests fibrin clot after repair is complete.
c. Kinin: Involved in contact activation.

Question 3

Which of the following is primarily responsible for neutralizing the extrinsic tenase (Xase) complex?

Accepted Answer

A)  TFPI 
B)  SERPINs 
C)  Proteins C and S 
D)  APS 
A)  TFPI 
B)  SERPINs 
C)  Proteins C and S 
D)  APS A

Question 4

Which of the following is a role of thrombin?

Accepted Answer

A)  Activates anticoagulant (protein 
C)  
B)  Increases fibrinolysis 
C)  Inhibits endothelial cell release of tissue plasminogen activator 
D)  Inhibits the formation of fibrin monomers 
A)  Activates anticoagulant (protein 
C)  
B)  Increases fibrinolysis 
C)  Inhibits endothelial cell release of tissue plasminogen activator 
D)  Inhibits the formation of fibrin monomers

Question 5

Which of the following is the smallest degradation product of fibrin?

Accepted Answer

A)  Fragment X 
B)  Fragment Y 
C)  D-dimer 
D)  E fragment 
A)  Fragment X 
B)  Fragment Y 
C)  D-dimer 
D)  E fragment

Question 6

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

Accepted Answer

A)  Fibrin 
B)  Tissue factor 
C)  Plasminogen 
D)  Thrombin 
A)  Fibrin 
B)  Tissue factor 
C)  Plasminogen 
D)  Thrombin

Question 7

The role of vitamin K in hemostasis is to:

Accepted Answer

A)  Promote contact factor activation 
B)  Facilitate calcium binding to essential factors 
C)  Initiate extrinsic pathway activation 
D)  Cross-link the fibrin monomers 
A)  Promote contact factor activation 
B)  Facilitate calcium binding to essential factors 
C)  Initiate extrinsic pathway activation 
D)  Cross-link the fibrin monomers

Question 8

Which of the following coagulation factors is(are) found in the extrinsic pathway?

Accepted Answer

A)  HK and FXII 
B)  FXI and FIX 
C)  FVII and TF 
D)  FX 
A)  HK and FXII 
B)  FXI and FIX 
C)  FVII and TF 
D)  FX

Question 9

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophilia?

Accepted Answer

A)  Platelet function assay 
B)  Factor assay 
C)  Quantitative fibrinogen assay 
D)  Assay for D-dimer 
A)  Platelet function assay 
B)  Factor assay 
C)  Quantitative fibrinogen assay 
D)  Assay for D-dimer

Question 10

Which of the following is not formed on a phospholipid surface?

Accepted Answer

A)  Extrinsic Xase 
B)  Intrinsic Xase 
C)  Prothrombinase 
D)  Factor VIIa 
A)  Extrinsic Xase 
B)  Intrinsic Xase 
C)  Prothrombinase 
D)  Factor VIIa

Question 11

Fill in the missing factors in the traditional coagulation cascade:

Accepted Answer

1. XII, 2. XIIa, 3. XI, 4. XIa

Question 12

Which plasminogen activator (PA) is distinctive among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Accepted Answer

A)  uPA 
B)  uPAR 
C)  PLG 
D)  tPA 
A)  uPA 
B)  uPAR 
C)  PLG 
D)  tPA

Question 13

Complete the following table by listing the coag factors in the Intrinsic, Extrinsic and Common Pathways using both the Factor designation and common name.

Accepted Answer

The answer of Complete the following table by listing the...

Question 14

What are the roles of thrombin in coagulation?

Accepted Answer

• Platelet aggregation
• Factor activati

Question 15

On which chromosome does the factor VIII locus reside?

Accepted Answer

A)  3 
B)  4 
C)  11 
D)  X 
A)  3 
B)  4 
C)  11 
D)  X

Question 16

The prothrombin group includes of which of the following?

Accepted Answer

A)  Factor V 
B)  Factor VII 
C)  Factor XII 
D)  Factor VIII 
A)  Factor V 
B)  Factor VII 
C)  Factor XII 
D)  Factor VIII

Question 17

Activation of circulating zymogens is achieved through:

Accepted Answer

A)  Sympathetic nervous system stimulation 
B)  Endomitosis 
C)  Splenic sequestration 
D)  Proteolytic cleavage 
A)  Sympathetic nervous system stimulation 
B)  Endomitosis 
C)  Splenic sequestration 
D)  Proteolytic cleavage

Question 18

How does systemic fibrinolysis differ from physiologic fibrinolysis?

Accepted Answer

A)  Systemic produces rapid fibrinolysis, whereas physiologic produces adequate fibrinolysis. 
B)  Systemic results from improper plasminogen activation, whereas physiologic results from proper plasminogen activation. 
C)  Physiologic is naturally occurring, whereas systemic results from an external trigger. 
D)  Physiologic is localized to the fibrin clot, whereas systemic results in circulating plasmin. 
A)  Systemic produces rapid fibrinolysis, whereas physiologic produces adequate fibrinolysis. 
B)  Systemic results from improper plasminogen activation, whereas physiologic results from proper plasminogen activation. 
C)  Physiologic is naturally occurring, whereas systemic results from an external trigger. 
D)  Physiologic is localized to the fibrin clot, whereas systemic results in circulating plasmin.

Question 19

Which domain of the blood coagulation protein is responsible for its distinctive identity?

Accepted Answer

A)  Signal peptide domain 
B)  Catalytic domain 
C)  Epidermal growth factor domain 
D)  Noncatalytic domain 
A)  Signal peptide domain 
B)  Catalytic domain 
C)  Epidermal growth factor domain 
D)  Noncatalytic domain

Question 20

Compare and contrast systemic and physiologic fibrinolysis.

Accepted Answer

Physiologic fibrinolysis: highly fibrin-

Exam 32: Secondary Hemostasis and Fibrinolysis

Which of the following is not involved in "contact activation"?

How do the following systems contribute to coagulation? a. Complement b. Fibrinolysis c. Kinin

Which of the following is primarily responsible for neutralizing the extrinsic tenase (Xase) complex?

Which of the following is a role of thrombin?

Which of the following is the smallest degradation product of fibrin?

What is the key component in secondary hemostasis that binds the platelets into a solid plug?

The role of vitamin K in hemostasis is to:

Which of the following coagulation factors is(are) found in the extrinsic pathway?

What reflex test should be done on a patient with an abnormal APTT who is suspected of having hemophilia?

Which of the following is not formed on a phospholipid surface?

Fill in the missing factors in the traditional coagulation cascade:

Which plasminogen activator (PA) is distinctive among the serine proteases because it does not circulate as a zymogen but is fully active toward its substrate plasminogen in a single-chain form?

Complete the following table by listing the coag factors in the Intrinsic, Extrinsic and Common Pathways using both the Factor designation and common name.

What are the roles of thrombin in coagulation?

On which chromosome does the factor VIII locus reside?

The prothrombin group includes of which of the following?

Activation of circulating zymogens is achieved through:

How does systemic fibrinolysis differ from physiologic fibrinolysis?

Which domain of the blood coagulation protein is responsible for its distinctive identity?

Compare and contrast systemic and physiologic fibrinolysis.

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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