Question 1

All of the following are necessary for a clot to form except:

Accepted Answer

A)  Platelets 
B)  Coagulation protein 
C)  Plasmin 
D)  Endothelial cells 
A)  Platelets 
B)  Coagulation protein 
C)  Plasmin 
D)  Endothelial cells

Question 2

Thrombin activatable fibrinolysis inhibitor (TAFI) is defined as a:

Accepted Answer

A)  Procoagulant 
B)  Anticoagulant 
C)  Profibrinolytic 
D)  Antifibrinolytic 
A)  Procoagulant 
B)  Anticoagulant 
C)  Profibrinolytic 
D)  Antifibrinolytic

Question 3

Which of the following is not a role of high molecular weight kininogen?

Accepted Answer

A)  Accelerate the rate of surface-dependent activation of F-XII 
B)  Serves as a non-enzymatic cofactor in contact factor activation 
C)  Provide bradykinin 
D)  Accelerates the formation of Factor VIIa 
A)  Accelerate the rate of surface-dependent activation of F-XII 
B)  Serves as a non-enzymatic cofactor in contact factor activation 
C)  Provide bradykinin 
D)  Accelerates the formation of Factor VIIa

Question 4

Interpret the following results: • Patient: 12-year-old boy with unexplained bruising, swollen knee joints, and prolonged bleeding from injuries
• Screening tests:
O PT = 12.2 sec (control: 11.5-13.3 sec)/INR: 1.09
O APTT = 57 sec (control: 23-32 sec)
O Bleeding time = 5 min (control: 2-10 min)
Pending results from confirmation tests, this patient could be suffering from:

Accepted Answer

A)  An intrinsic pathway problem 
B)  An extrinsic pathway problem 
C)  A primary hemostasis problem 
D)  A common pathway problem 
A)  An intrinsic pathway problem 
B)  An extrinsic pathway problem 
C)  A primary hemostasis problem 
D)  A common pathway problem

Question 5

Thrombin activity impacts coagulation by which of the following mechanism(s)?

Accepted Answer

A)  Altering blood flow 
B)  Positive feedback only 
C)  Negative feedback only 
D)  Positive and negative feedback 
A)  Altering blood flow 
B)  Positive feedback only 
C)  Negative feedback only 
D)  Positive and negative feedback

Question 6

During activation of coagulation, all of the following bind to the phospholipid membrane surface forming a complex except:

Accepted Answer

A)  Procoagulant zymogen (substrate) 
B)  Coagulation inhibitors 
C)  Procoagulant cofactors 
D)  Activated serine protease 
A)  Procoagulant zymogen (substrate) 
B)  Coagulation inhibitors 
C)  Procoagulant cofactors 
D)  Activated serine protease

Question 7

Which of the following degrades factors V and VIII?

Accepted Answer

A)  TFPI 
B)  SERPINs 
C)  Proteins C and S 
D)  APS 
A)  TFPI 
B)  SERPINs 
C)  Proteins C and S 
D)  APS

Question 8

The substance directly responsible for the physical breakdown of the thrombus is:

Accepted Answer

A)  Plasmin 
B)  Plasminogen 
C)  Tissue plasminogen activator 
D)  Fibrin 
A)  Plasmin 
B)  Plasminogen 
C)  Tissue plasminogen activator 
D)  Fibrin

Question 9

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

Accepted Answer

A)  LRP 
B)  ADAMTS-13 
C)  EPCR 
D)  UPAR 
A)  LRP 
B)  ADAMTS-13 
C)  EPCR 
D)  UPAR

Question 10

Which of the following is responsible for urokinase-catalyzed plasminogen (PLG) activation?

Accepted Answer

A)  ADAMTS-13 
B)  LRP 
C)  UPAR 
D)  EPCR 
A)  ADAMTS-13 
B)  LRP 
C)  UPAR 
D)  EPCR

Question 11

Why is vitamin K necessary for some coagulation proteins to become functional?

Accepted Answer

A)  Vitamin K activates coagulation zymogens. 
B)  Vitamin K binds coagulation factors to a phospholipid surface. 
C)  Vitamin K combines with VWF in the circulation. 
D)  Vitamin K is required for gamma-carboxylation of glutamic acid residues. 
A)  Vitamin K activates coagulation zymogens. 
B)  Vitamin K binds coagulation factors to a phospholipid surface. 
C)  Vitamin K combines with VWF in the circulation. 
D)  Vitamin K is required for gamma-carboxylation of glutamic acid residues.

Question 12

Triggering the contact activation factors of the intrinsic pathway does not require which of the following components?

Accepted Answer

A)  Vitamin K 
B)  Calcium  
C)  Serine protease 
D)  Kinins 
A)  Vitamin K 
B)  Calcium  
C)  Serine protease 
D)  Kinins

Question 13

Hemostasis depends on which of the following?

Accepted Answer

A)  The interaction between coagulation and fibrinolysis inhibitors 
B)  The interaction between platelets, coagulation proteins, and blood vessels 
C)  The rate of platelet destruction 
D)  The rate of endothelial cell turnover 
A)  The interaction between coagulation and fibrinolysis inhibitors 
B)  The interaction between platelets, coagulation proteins, and blood vessels 
C)  The rate of platelet destruction 
D)  The rate of endothelial cell turnover

Question 14

What factor does the extrinsic pathway require that the intrinsic and common pathways do not?

Accepted Answer

A)  Vitamin K 
B)  Zymogens 
C)  Tissue factor 
D)  tPA 
A)  Vitamin K 
B)  Zymogens 
C)  Tissue factor 
D)  tPA

Question 15

Platelet activation and subsequent formation of the platelet plug are involved in:

Accepted Answer

A)  Primary hemostasis 
B)  Secondary hemostasis 
C)  Fibrinolysis 
D)  Inhibitory system 
A)  Primary hemostasis 
B)  Secondary hemostasis 
C)  Fibrinolysis 
D)  Inhibitory system

Exam 32: Secondary Hemostasis and Fibrinolysis

All of the following are necessary for a clot to form except:

Thrombin activatable fibrinolysis inhibitor (TAFI) is defined as a:

Which of the following is not a role of high molecular weight kininogen?

Thrombin activity impacts coagulation by which of the following mechanism(s)?

During activation of coagulation, all of the following bind to the phospholipid membrane surface forming a complex except:

Which of the following degrades factors V and VIII?

The substance directly responsible for the physical breakdown of the thrombus is:

Which of the following is responsible for cleaving ultra-large VWF multimers into functional units?

Which of the following is responsible for urokinase-catalyzed plasminogen (PLG) activation?

Why is vitamin K necessary for some coagulation proteins to become functional?

Triggering the contact activation factors of the intrinsic pathway does not require which of the following components?

Hemostasis depends on which of the following?

What factor does the extrinsic pathway require that the intrinsic and common pathways do not?

Platelet activation and subsequent formation of the platelet plug are involved in:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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