Exam 23: Introduction to Hematopoietic Neoplasms

A gene involved in regulating the growth of myeloid cells is hypermethylated, resulting in a block in transcription. This is an example of malignancy as a result of:

A bone marrow differential is performed on a patient suspected of having leukemia. Cytochemical stains are performed. MPO and SBB are negative. Blasts appear homogeneous and small in size. What would you expect to find when performing immunophenotyping?

Which patient population is most affected by acute lymphoblastic leukemia?

What is(are) the common complication(s) of chemotherapy?

Which of the following is a complication of leukemia treatment?

TSG, or the tumor suppressor gene, plays a role in neoplastic transformation of cells by what mechanism?

Leukemias are classified as:

Somatic cell chromosome mutations resulting in hematologic neoplasms are associated with:

Name the two main classification systems that identify MDS and acute leukemia. Indicate how they are different.

Which of the following combinations leads to tumor formation?

Cell lineage of leukemic blasts can be determined by:

For the following cytochemical stains, indicate their expected results for (a) ALL and (b) AML. a. MPO b. SBB c. PAS d. TdT

Explain how proto-oncogenes contribute to tumor formation.

Which of the following disorders is characterized by signs of dyshematopoiesis?

Which of the following have the potential to progress into acute leukemia?

The HSC and the cancer stem cell are similar in:

Which two stains are used to differentiate the myeloid from the lymphoid blasts?

The purpose of the induction phase in chemotherapy is to:

A patient has a WBC count of 250 × 10⁹/L, and a peripheral blood smear contains many granulocytes and granulocytic precursors including 2% blasts. Pending further tests, which of the following neoplastic conditions is the most likely diagnosis?

Which disease state has Auer bodies present on examination of the blood smear?