Question 1

All of the following have been proposed as being leukemogenic except:

Accepted Answer

A)  Therapeutic radiation 
B)  Living in high altitude 
C)  Chromosome translocation 
D)  Benzene 
A)  Therapeutic radiation 
B)  Living in high altitude 
C)  Chromosome translocation 
D)  Benzene

Question 2

Which of the following laboratory analyses can be used to diagnose hematopoietic neoplasms?

Accepted Answer

A)  Cell morphology 
B)  Immunophenotyping 
C)  Cytogenetics 
D)  All of the above 
A)  Cell morphology 
B)  Immunophenotyping 
C)  Cytogenetics 
D)  All of the above

Question 3

A malignant neoplasm is best described as which of the following?

Accepted Answer

A)  A clone of normal, proliferating cells 
B)  A clone of abnormal, anaplastic, proliferating cells that have the potential to metastasize 
C)  A clone of highly organized, differentiated cells that have the potential to metastasize 
D)  A clone of highly organized, differentiated cells that do not spread 
A)  A clone of normal, proliferating cells 
B)  A clone of abnormal, anaplastic, proliferating cells that have the potential to metastasize 
C)  A clone of highly organized, differentiated cells that have the potential to metastasize 
D)  A clone of highly organized, differentiated cells that do not spread

Question 4

In what age group does chronic leukemia usually occur?

Accepted Answer

A)  All 
B)  Children 
C)  Adults 
D)  15-20 years of age 
A)  All 
B)  Children 
C)  Adults 
D)  15-20 years of age

Question 5

Which of the following has the best prognosis?

Accepted Answer

A)  ALL in children 
B)  ALL in adults 
C)  AML in adults 
D)  AML in children 
A)  ALL in children 
B)  ALL in adults 
C)  AML in adults 
D)  AML in children

Question 6

Bleeding, infections, and anemia are common complications of chemotherapy because:

Accepted Answer

A)  Drugs are used kill normal cells as well as leukemic cells 
B)  Normal cells are more susceptible to drug-induced apoptosis than leukemic cells 
C)  Drugs bind preferentially to normal cells 
D)  Drugs induce the formation of autoantibodies to normal cells 
A)  Drugs are used kill normal cells as well as leukemic cells 
B)  Normal cells are more susceptible to drug-induced apoptosis than leukemic cells 
C)  Drugs bind preferentially to normal cells 
D)  Drugs induce the formation of autoantibodies to normal cells

Question 7

A routine CBC from a 5-year-old boy shows 90% blasts in peripheral circulation. Cytochemical staining with SBB was negative and TdT was positive. Based on these findings, what is a probable diagnosis?

Accepted Answer

A)  AML 
B)  ALL 
C)  CML 
D)  CLL 
A)  AML 
B)  ALL 
C)  CML 
D)  CLL

Question 8

How are oncogenes and proto-oncogenes different?

Accepted Answer

A)  Proto-oncogenes are activated tumor genes, whereas oncogenes are inactivated tumor suppressor genes. 
B)  Oncogenes can lead to tumor formation, whereas proto-oncogenes prevent tumor formation. 
C)  Oncogenes can lead to tumor formation, whereas proto-oncogenes are inactivated forms of oncogenes. 
D)  Oncogenes are tumor suppressors, whereas proto-oncogenes cause tumor formation. 
A)  Proto-oncogenes are activated tumor genes, whereas oncogenes are inactivated tumor suppressor genes. 
B)  Oncogenes can lead to tumor formation, whereas proto-oncogenes prevent tumor formation. 
C)  Oncogenes can lead to tumor formation, whereas proto-oncogenes are inactivated forms of oncogenes. 
D)  Oncogenes are tumor suppressors, whereas proto-oncogenes cause tumor formation.

Question 9

Which of the following cytochemical stains can help differentiate AML from ALL?

Accepted Answer

A)  PAS stain 
B)  LAP stain 
C)  MPO stain 
D)  NSE stain 
A)  PAS stain 
B)  LAP stain 
C)  MPO stain 
D)  NSE stain

Question 10

Which of the following does the World Health Organization use to classify hematopoietic neoplasms?

Accepted Answer

A)  Lineage morphology 
B)  Clinical presentation 
C)  HIV status 
D)  DNA profiling 
A)  Lineage morphology 
B)  Clinical presentation 
C)  HIV status 
D)  DNA profiling

Question 11

Which progenitor cells normally do not have the capacity for self-renewal?

Accepted Answer

A)  CMP and CLP 
B)  HSC 
C)  Somatic cells 
D)  Primitive hematopoietic precursor cells 
A)  CMP and CLP 
B)  HSC 
C)  Somatic cells 
D)  Primitive hematopoietic precursor cells

Question 12

What is the difference between the HSC and the cancer stem cell?

Accepted Answer

The cancer stem cell has unlim

Question 13

Which laboratory test confirms the lineage of hematologic neoplasms?

Accepted Answer

A)  Cytogenetic analysis 
B)  Immunophenotyping 
C)  Nuclear staining 
D)  Bone marrow differential 
A)  Cytogenetic analysis 
B)  Immunophenotyping 
C)  Nuclear staining 
D)  Bone marrow differential

Exam 23: Introduction to Hematopoietic Neoplasms

All of the following have been proposed as being leukemogenic except:

Which of the following laboratory analyses can be used to diagnose hematopoietic neoplasms?

A malignant neoplasm is best described as which of the following?

In what age group does chronic leukemia usually occur?

Which of the following has the best prognosis?

Bleeding, infections, and anemia are common complications of chemotherapy because:

A routine CBC from a 5-year-old boy shows 90% blasts in peripheral circulation. Cytochemical staining with SBB was negative and TdT was positive. Based on these findings, what is a probable diagnosis?

How are oncogenes and proto-oncogenes different?

Which of the following cytochemical stains can help differentiate AML from ALL?

Which of the following does the World Health Organization use to classify hematopoietic neoplasms?

Which progenitor cells normally do not have the capacity for self-renewal?

What is the difference between the HSC and the cancer stem cell?

Which laboratory test confirms the lineage of hematologic neoplasms?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters