A 5-year-old girl has a WBC count of 8.4 × 109/L with 55% lymphocytes. Which of the following best describes this phenomenon?

A) Absolute lymphocytosis B) Relative lymphocytosis C) Normal leukocyte count D) Absolute lymphocytopenia A) Absolute lymphocytosis B) Relative lymphocytosis C) Normal leukocyte count D) Absolute lymphocytopenia C

A 19-year-old male visits his physician because of a persistent cough and progressive fatigue over the past month. Physical examination reveals prominent lymphadenopathy. Laboratory analysis reveals a WBC count of 20 × 109/L with 23% reactive lymphocytes. Patient serum is positive for both IgG and IgM antibodies against EBV. Based on this information, from what is the patient most likely suffering?

A) Hodgkin lymphoma B) Reactive leukocytosis C) Infectious mononucleosis D) Malaria A) Hodgkin lymphoma B) Reactive leukocytosis C) Infectious mononucleosis D) Malaria

Exam 22: Nonmalignant Lymphocyte Disorders

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Correlate each disorder with the following: (1) population(s) most affected by it, (2) whether it produces a lymphocytosis or lymphocytopenia, (3) morphology associated with it, and (4) pathophysiology of the infection. a. Infectious mononucleosis b. Whooping cough c. Toxoplasmosis d. CMV infection

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Question 1

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a. Infectious mononucleosis
1. Children, teenagers, adults
2. Lymphocytosis
3. Activated lymphocytes: oval nucleus, abundant cytoplasm, basophilic rim, loss of contact inhibition
4. Lymphocytes are infected with EBV.
b. Whooping cough
1. Children
2. Lymphocytosis
3. Lymphocytes with clumped chromatin and indistinct nucleoli
4. Pertussis toxin causes migration of lymphocytes from lymphatic system to the blood and blocks their return to the lymphatic system.
c. Toxoplasmosis
1. Growing fetus, pregnant mother
2. Lymphocytosis
3. Lymphocytes resemble lymphoblasts or lymphoma cells.
4. Toxoplasma gondii causes follicular hyperplasia that spills over into the blood.
d. CMV infection
1. Transplant patients, immunocompromised patients
2. Lymphocytosis
3. Reactive lymphocytes
4. CMV infects neutrophils and suppresses cell-mediated immunity.

Which of the following disorders is associated with a lymphocytosis?

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Question 2

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A 5-year-old girl has a WBC count of 8.4 × 10⁹/L with 55% lymphocytes. Which of the following best describes this phenomenon?

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Question 3

Correct Answer:

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What characteristics are associated with reactive lymphocytes?

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Question 4

Diagnosis of an active toxoplasmosis infection is established by?

(Multiple Choice)

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Question 5

Which of the following infectious agents that can be transmitted from mother to a growing fetus can result in physically and mentally impaired development?

(Multiple Choice)

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Question 6

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes. What can explain this phenomenon?

(Multiple Choice)

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Question 7

A 19-year-old male visits his physician because of a persistent cough and progressive fatigue over the past month. Physical examination reveals prominent lymphadenopathy. Laboratory analysis reveals a WBC count of 20 × 10⁹/L with 23% reactive lymphocytes. Patient serum is positive for both IgG and IgM antibodies against EBV. Based on this information, from what is the patient most likely suffering?

(Multiple Choice)

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Question 8

What are the most common laboratory findings in CMV infection in the newborn?

(Multiple Choice)

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Question 9

CMV infections complicate transplants by which of the following mechanisms?

(Multiple Choice)

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Question 10

A patient with infectious mononucleosis is having serologic blood tests. Results are as follows: EBVCA IgG: 1:320; EBVCA IgM: not detected; EBNA: 1:20. What stage of infection is the patient in?

(Multiple Choice)

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Question 11

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks. What morphologic characteristics are present in the blood smear?

(Multiple Choice)

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Question 12

A 17 year-old female was seen in ER for fever, sore throat, headache and general malaise. The CBC showed a leukocytosis and absolute lymphocytosis. The peripheral smear showed a heterogenous mix of lymphocytes with many large, irregular shaped cells with spreading cytoplasm and irregular basophilia. What is your diagnosis and what follow up testing would you preform to confirm that?

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Question 13

What is the agent responsible for infectious mononucleosis?

(Multiple Choice)

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Question 14

The Epstein-Barr virus targets B cells that express . Once infected, they cause expression of the marker.

(Multiple Choice)

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Question 15

What component is responsible for the accumulation of lymphocytes in the blood during a whooping cough infection?

(Multiple Choice)

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Question 16

HIES is due to a deficiency in:

(Multiple Choice)

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Question 17

Bordetella pertussis and chronic lymphocytic leukemia have increased small lymphocytes with condensed nuclear chromatin on the blood smear. What laboratory test could distinguish whooping cough from CLL?

(Multiple Choice)

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Question 18

Which of the following statements best describes the pathogenesis of HIV infection?

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Question 19

Correlate antibody titers with the stage of infection. What antibody titer excludes current infection?

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Question 20

Showing 1 - 20 of 35

Exam 22: Nonmalignant Lymphocyte Disorders

Correlate each disorder with the following: (1) population(s) most affected by it, (2) whether it produces a lymphocytosis or lymphocytopenia, (3) morphology associated with it, and (4) pathophysiology of the infection. a. Infectious mononucleosis b. Whooping cough c. Toxoplasmosis d. CMV infection

Which of the following disorders is associated with a lymphocytosis?

A 5-year-old girl has a WBC count of 8.4 × 109/L with 55% lymphocytes. Which of the following best describes this phenomenon?

What characteristics are associated with reactive lymphocytes?

Diagnosis of an active toxoplasmosis infection is established by?

Which of the following infectious agents that can be transmitted from mother to a growing fetus can result in physically and mentally impaired development?

Bordetella pertussis is characterized by rapid peripheral lymphocytosis and decreased cellularity of the lymph nodes. What can explain this phenomenon?

What are the most common laboratory findings in CMV infection in the newborn?

CMV infections complicate transplants by which of the following mechanisms?

A patient with infectious mononucleosis is having serologic blood tests. Results are as follows: EBVCA IgG: 1:320; EBVCA IgM: not detected; EBNA: 1:20. What stage of infection is the patient in?

Lymphocytosis is found about 1 week after symptoms appear in infectious mononucleosis and lymphocytes remain elevated for 2-8 weeks. What morphologic characteristics are present in the blood smear?

What is the agent responsible for infectious mononucleosis?

The Epstein-Barr virus targets B cells that express ________. Once infected, they cause expression of the ________ marker.

What component is responsible for the accumulation of lymphocytes in the blood during a whooping cough infection?

HIES is due to a deficiency in:

Bordetella pertussis and chronic lymphocytic leukemia have increased small lymphocytes with condensed nuclear chromatin on the blood smear. What laboratory test could distinguish whooping cough from CLL?

Which of the following statements best describes the pathogenesis of HIV infection?

Correlate antibody titers with the stage of infection. What antibody titer excludes current infection?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters

A 5-year-old girl has a WBC count of 8.4 × 10⁹/L with 55% lymphocytes. Which of the following best describes this phenomenon?

The Epstein-Barr virus targets B cells that express . Once infected, they cause expression of the marker.