Question 1

Which of the following assays differentiate CNL from CML?

Accepted Answer

A)  Hematocrit 
B)  WBC count 
C)  LAP 
D)  Bone marrow fibrosis 
A)  Hematocrit 
B)  WBC count 
C)  LAP 
D)  Bone marrow fibrosis C

Question 2

A patient's CBC revealed marked leukocytosis with an increased number of immature granulocytes. A few promyelocytes and blasts were seen. There were also an increased number of eosinophils and basophils with rare immature forms. The hemoglobin and hematocrit were normal, but platelets were slightly decreased. Which disorder is associated with these findings?

Accepted Answer

A)  Leukemoid reaction 
B)  CML 
C)  PMF 
D)  Severe infection 
A)  Leukemoid reaction 
B)  CML 
C)  PMF 
D)  Severe infection B

Question 3

What laboratory finding distinguishes leukemoid reaction from CML?

Accepted Answer

A)  Platelets normal in CML, abnormal in leukemoid reaction 
B)  LAP low in CML, increased in leukemoid reaction 
C)  Blasts only in leukemoid reaction 
D)  Occasional micromegakaryocytes in leukemoid reaction 
A)  Platelets normal in CML, abnormal in leukemoid reaction 
B)  LAP low in CML, increased in leukemoid reaction 
C)  Blasts only in leukemoid reaction 
D)  Occasional micromegakaryocytes in leukemoid reaction B

Question 4

CML is typically diagnosed in which patient population?

Accepted Answer

A)  Male children 
B)  Female adults 
C)  Elderly male and female patients 
D)  Teenagers 
A)  Male children 
B)  Female adults 
C)  Elderly male and female patients 
D)  Teenagers

Question 5

Which of the following test results is most consistent with a diagnosis of PMF?

Accepted Answer

A)  >30% blasts in the peripheral blood 
B)  High WBC count 
C)  Dacryocytes in the peripheral blood 
D)  High PLT count 
A)  >30% blasts in the peripheral blood 
B)  High WBC count 
C)  Dacryocytes in the peripheral blood 
D)  High PLT count

Question 6

The role of PDGF in PMF is to:

Accepted Answer

A)  Promote dysplasia of hematopoietic dividing cells 
B)  Promote proliferation of bone marrow fibroblasts 
C)  Inhibit normal hematopoiesis 
D)  Inhibit erythropoiesis 
A)  Promote dysplasia of hematopoietic dividing cells 
B)  Promote proliferation of bone marrow fibroblasts 
C)  Inhibit normal hematopoiesis 
D)  Inhibit erythropoiesis

Question 7

Increased sensitivity to which cytokine(s) is thought to be partially responsible for the increased megakaryocyte proliferation of ET?

Accepted Answer

A)  GM-CSF 
B)  IL-3 and IL-6 
C)  EPO, SCF, and IL-4 
D)  EPO, MPL, and CSF-G 
A)  GM-CSF 
B)  IL-3 and IL-6 
C)  EPO, SCF, and IL-4 
D)  EPO, MPL, and CSF-G

Question 8

How would you confirm a variant of CML?

Accepted Answer

A)  Verify BCL/ABL fusion using FISH analysis. 
B)  Perform a bone marrow aspirate. 
C)  Take an accurate drug history. 
D)  Perform cytochemical staining for MPO and PAS. 
A)  Verify BCL/ABL fusion using FISH analysis. 
B)  Perform a bone marrow aspirate. 
C)  Take an accurate drug history. 
D)  Perform cytochemical staining for MPO and PAS.

Question 9

Explain the significance of the Philadelphia chromosome in ALL.

Accepted Answer

Two different types of proteins are asso

Question 10

What feature distinguishes CML from a leukemoid reaction?

Accepted Answer

A)  CML has no blasts in the peripheral blood; in a leukemoid reaction, blasts are common. 
B)  CML often has abnormal platelet morphology, and leukemoid reaction has normal platelets. 
C)  LAP is increased in CML and decreased in leukemoid reaction. 
D)  Chromosome karyotype is abnormal in leukemoid reaction and normal in CML. 
A)  CML has no blasts in the peripheral blood; in a leukemoid reaction, blasts are common. 
B)  CML often has abnormal platelet morphology, and leukemoid reaction has normal platelets. 
C)  LAP is increased in CML and decreased in leukemoid reaction. 
D)  Chromosome karyotype is abnormal in leukemoid reaction and normal in CML.

Question 11

Which age range is nearest to the peak incidence of CML?

Accepted Answer

A)  0-5 years 
B)  20-25 years 
C)  35-45 years 
D)  55-65 years 
A)  0-5 years 
B)  20-25 years 
C)  35-45 years 
D)  55-65 years

Question 12

CML is characterized by which of the following:

Accepted Answer

A)  A shift to the left in WBCs 
B)  A massive increase in mature WBCs 
C)  A peripheral blood or bone marrow blast count >20% 
D)  A shift to the left in RBCs, platelets, and WBCs 
A)  A shift to the left in WBCs 
B)  A massive increase in mature WBCs 
C)  A peripheral blood or bone marrow blast count >20% 
D)  A shift to the left in RBCs, platelets, and WBCs

Question 13

The Philadelphia chromosome results from the fusion of which of the following?

Accepted Answer

A)  Chromosomes 9 and 22 
B)  Chromosomes 15 and 17 
C)  Chromosomes 8 and 21 
D)  Chromosomes 8 and 14 
A)  Chromosomes 9 and 22 
B)  Chromosomes 15 and 17 
C)  Chromosomes 8 and 21 
D)  Chromosomes 8 and 14

Question 14

Which of the following tests would help differentiate primary polycythemia from secondary polycythemia?

Accepted Answer

A)  EPO 
B)  Vitamin B12 
C)  Iron 
D)  LAP score 
A)  EPO 
B)  Vitamin B12 
C)  Iron 
D)  LAP score

Question 15

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Accepted Answer

A)  Acute lymphoid leukemia 
B)  Chronic myelogenous leukemia 
C)  Chronic lymphocytic leukemia 
D)  Leukemic hiatus 
A)  Acute lymphoid leukemia 
B)  Chronic myelogenous leukemia 
C)  Chronic lymphocytic leukemia 
D)  Leukemic hiatus

Question 16

Which of the following are criteria for systemic mastocytosis?

Accepted Answer

A)  Atypical morphology in >25% of mast cells 
B)  >25% of all mast cells in the bone marrow immature or atypical 
C)  Presence of KIT point mutation in mast cells 
D)  All of the above 
A)  Atypical morphology in >25% of mast cells 
B)  >25% of all mast cells in the bone marrow immature or atypical 
C)  Presence of KIT point mutation in mast cells 
D)  All of the above

Question 17

Which of the following is described by the presence of circulating mast cells in the peripheral blood (≥ 10%), mast cells composing > 20% of the nucleated cells in bone marrow, and multiorgan failure:

Accepted Answer

A)  MPN, U 
B)  Mast cell leukemia 
C)  PV 
D)  Clonal hypereosinophilia 
A)  MPN, U 
B)  Mast cell leukemia 
C)  PV 
D)  Clonal hypereosinophilia

Question 18

Contrast MDS and MPN utilizing laboratory test result information.

Accepted Answer

MPN represents an excessive proliferatio

Question 19

A 45-year-old male patient presents to his physician with a palpable spleen. A CBC reveals an absolute eosinophil count of 2.5 × 109/L. After six weeks, the patient's CBC indicates an absolute eosinophil count of 2.9 × 109/L. Which of the following is a likely diagnosis for this patient?

Accepted Answer

A)  Severe infection 
B)  Leukemoid reaction 
C)  MPN, U 
D)  Clonal hypereosinophilia 
A)  Severe infection 
B)  Leukemoid reaction 
C)  MPN, U 
D)  Clonal hypereosinophilia

Question 20

Interpret the following results: WBC count: 102 × 109/L
Differential:
13% segmented neutrophils
28% band neutrophils
15% metamyelocytes
8% myelocytes
6% promyelocytes
15% lymphocytes
8% basophils
7% monocytes
LAP score: 15 (reference interval: 0-400)
What disease is associated with this WBC differential and LAP score?

Accepted Answer

A)  None 
B)  CML 
C)  CNL 
D)  Leukemoid reaction 
A)  None 
B)  CML 
C)  CNL 
D)  Leukemoid reaction

Exam 24: Myeloproliferative Neoplasms

Which of the following assays differentiate CNL from CML?

What laboratory finding distinguishes leukemoid reaction from CML?

CML is typically diagnosed in which patient population?

Which of the following test results is most consistent with a diagnosis of PMF?

The role of PDGF in PMF is to:

Increased sensitivity to which cytokine(s) is thought to be partially responsible for the increased megakaryocyte proliferation of ET?

How would you confirm a variant of CML?

Explain the significance of the Philadelphia chromosome in ALL.

What feature distinguishes CML from a leukemoid reaction?

Which age range is nearest to the peak incidence of CML?

CML is characterized by which of the following:

The Philadelphia chromosome results from the fusion of which of the following?

Which of the following tests would help differentiate primary polycythemia from secondary polycythemia?

An abundance of blasts and some mature forms with an apparent decrease in the intermediate maturational stages is referred to as:

Which of the following are criteria for systemic mastocytosis?

Which of the following is described by the presence of circulating mast cells in the peripheral blood (≥ 10%), mast cells composing > 20% of the nucleated cells in bone marrow, and multiorgan failure:

Contrast MDS and MPN utilizing laboratory test result information.

A 45-year-old male patient presents to his physician with a palpable spleen. A CBC reveals an absolute eosinophil count of 2.5 × 109/L. After six weeks, the patient's CBC indicates an absolute eosinophil count of 2.9 × 109/L. Which of the following is a likely diagnosis for this patient?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters

A 45-year-old male patient presents to his physician with a palpable spleen. A CBC reveals an absolute eosinophil count of 2.5 × 10⁹/L. After six weeks, the patient's CBC indicates an absolute eosinophil count of 2.9 × 10⁹/L. Which of the following is a likely diagnosis for this patient?