Exam 24: Myeloproliferative Neoplasms

The characteristic poikilocyte often seen in the peripheral blood of patients with PMF that indicates extramedullary hematopoiesis is:

What substance(s) is(are) primarily responsible for stimulating the growth and proliferation of fibroblasts in PMF?

A known CML patient's blood is received in the lab for a routine CBC. The laboraty professional counts 55% blasts in the smear. The most likely reason for this occurrence is that the patient is in:

The key factor to distinguish relative and absolute polycythemia is that a relative polycythemia is caused by:

Which myeloproliferative disorder typically produces a dramatic increase in all cell lines?

A 45-year-old patient visits his physician for a routine examination to address his hypertension. The patient has prominent splenomegaly and rosy cheeks. He is also a smoker. Lab values are: EPO: elevated WBC count: 18.4 × 10⁹/L4 RBC: 6.84 × 10¹²/L PLT: 705 × 10⁹/L Based on these findings, what would you expect to find in the bone marrow?

Which is a characteristic of ET that would help distinguish it from reactive thrombocytosis?

A routine CBC is ordered on a patient. Results are as follows: WBC count: 22.0 × 10⁹/L PLT: 957 × 10⁹/L RBC: 5.00 × 10¹²/L PB smear: moderate platelet clumping and giant platelets noted These results are characteristic of which disorder?

Compare and contrast MPN and MDS with regard to proliferation, differentiation, and cell death.

A patient's laboratory results indicate a markedly increased hemoglobin, hematocrit, and red blood cell count. White blood cells and platelets are also slightly increased. The erythropoietin level is decreased. Which is most likely:

Which of the following genes is associated with clonal hypereosinophilia?

Which of the following myeloproliferative disorders is characterized by an elevated white count and a markedly elevated platelet count?

Which is found in >90% of cases of PV and promotes EPO receptor activation?

The presence of which of the following in the bone marrow would lead a clinician to the diagnosis of a myeloproliferative disorder rather than an acute leukemia?

A patient presents with a moderate leukoerythroblastic anemia, striking anisocytosis, and poikilocytosis. The anemia is normocytic, normochromic. Large platelets are noted. Dacryocytes, elliptocytes, and ovalocytes are present. Basophilic stippling is present. What disease is associated with these findings?

Which CBC findings would suggest an MPN?

The myeloproliferative disorder best described by increased leukocytes, immature granulocytes, and decreased LAP with the Philadelphia chromosome present is which of the following?

Contrast primary polycythemia and secondary polycythemia based on pathophysiology.

Which of the following tests would help differentiate ET from other causes of thrombocytosis?

A physician strongly suspects CML in a patient and has already ordered a bone marrow differential and cytogenetic analysis for the Philadelphia chromosome. What other test would help confirm the CML picture for this patient?