Exam 24: Myeloproliferative Neoplasms

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The most striking finding in the peripheral blood in this disease is extreme and consistent thrombocytosis. Giant, bizarre platelet forms are present in the peripheral blood. Megakaryocytes and megakaryocyte fragments can be present. Abnormalities in platelet aggregation and adhesion are common. What is this disease?

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What cell appears to be the primary site for the defect in MPN?

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The major cell line involved in the pathogenesis of PMF is which of the following?

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