Exam 19: Hemolytic Anemia: Immune Anemias

During transfusion, a patient developed pain in the area of the needle, shortness of breath, and chest tightness. What is the most likely cause?

Explain why the DAT profile in CAD is reactive only with polyspecific AHG and anti-C3 but not with anti-IgG.

Paroxysmal cold hemoglobinuria is associated with viral and bacterial infections in children. With what other disease(s) is it associated?

What test can demonstrate the presence of alloantibody?

Which of the following has the greatest effect on the rate of hemolysis in immune hemolytic anemia?

A 44-year-old female presents for her routine examination. She complains of tiredness and difficulty in breathing when she exerts herself. Her DAT is positive with polyspecific AHG and anti-IgG. Her hemoglobin is 7.5 gm/dl, and her indices suggest a normocytic, normochromic anemia. Her peripheral blood smear shows the presence of spherocytes. What is the most likely diagnosis?

The most likely cause of immediate hemolytic transfusion reaction is from antibodies of which system?

Which of the following antibody specificities is associated with PCH?

The absence of spherocytes on the peripheral blood smear in a case of suspected HDFN usually indicates that which of the following is the most likely cause of the condition?

All of the following are consistent with a diagnosis of CAD except?

2 to 14 days after a transfusion, a patient is cross-matched for another transfusion. Slight hemolysis and a positive DAT are found. What testing should follow?

Compare the three mechanisms of drug-induced immune hemolysis.