Exam 5: The Structure and Function of Large Biological Molecules

Misfolding of polypeptides is a serious problem in cells. Which of the following diseases are associated with an accumulation of misfolded polypeptides?

How many molecules of water are released during the polymerisation of a 20 monomer-long cellulose molecule?

"The native structure of h[a]emoglobin (Hb) comprises of two α and two β subunits, each of which carries a h[a]em group. There appear to be no previous studies that report the in-vitro folding and assembly of Hb from highly unfolded α and β globin in a 'one-pot' reaction. One difficulty that has to be overcome for studies of this kind is the tendency of Hb to aggregate during refolding. This work demonstrates that denaturation of Hb in 40% acetonitrile at pH 10.0 is reversible." (J Am Soc Mass Spectrum 2007, 18, 8-16) -Haemoglobin is ________.

- Which molecule has both hydrophilic and hydrophobic properties and is found in plasma membranes?

The structural level of a protein least affected by a disruption in hydrogen bonding is the

How do phospholipids interact with water molecules?

The chemical reaction illustrated ________.

One of the primary functions of RNA molecules is to ________.

A molecule with the chemical formula C₆H₁₂O₆ is probably a ________.

When nucleotides polymerise to form a nucleic acid, ________.

If 14C-labelled uracil is added to the growth medium of cells, what macromolecules will be labelled?

- Which of the following molecules is a purine nitrogenous base?

Which of the following is not a polymer?

You would like to lose weight. Which of the following should be your preferred food group?

The enzyme amylase can break glycosidic linkages between glucose monomers only if the monomers are in the form. Which of the following could amylase break down?

"The native structure of h[a]emoglobin (Hb) comprises of two α and two β subunits, each of which carries a h[a]em group. There appear to be no previous studies that report the in-vitro folding and assembly of Hb from highly unfolded α and β globin in a 'one-pot' reaction. One difficulty that has to be overcome for studies of this kind is the tendency of Hb to aggregate during refolding. This work demonstrates that denaturation of Hb in 40% acetonitrile at pH 10.0 is reversible." (J Am Soc Mass Spectrum 2007, 18, 8-16) - How many haeme groups are present in three haemoglobin protein molecules?

Which of the following categories includes all others in the list?

Maltose is a disaccharide that can easily be digested into glucose molecules. The glycosidic linkage between glucose molecules in maltose is ________.

- Which of the following combinations of molecules illustrated could be linked to form a nucleotide?

Phospholipids and triglycerides both ________.