Question 1

A catalog of common genetic variants that occur in humans is called a

Accepted Answer

A) haplotype map. 
B) restriction map. 
C) genomic map. 
D) SNP map. 
A) haplotype map. 
B) restriction map. 
C) genomic map. 
D) SNP map.

Question 2

Identical copies of genes that can be transcribed simultaneously are called

Accepted Answer

A) segmental duplications. 
B) pseudogenes. 
C) tandem clusters. 
D) multigene families. 
E) expressed sequences. 
A) segmental duplications. 
B) pseudogenes. 
C) tandem clusters. 
D) multigene families. 
E) expressed sequences.

Question 3

A private company has been hired by the parliament of ______ to create a data base from pooled medical,genetic,and genealogical information.

Accepted Answer

A) Nova Scotia 
B) Iceland 
C) Gibraltar 
D) Portugal 
E) Galapagos 
A) Nova Scotia 
B) Iceland 
C) Gibraltar 
D) Portugal 
E) Galapagos

Question 4

Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap),how many sequencing reactions would be needed to determine the complete human genome?

Accepted Answer

A) 3.2 billion 
B) 12.5 million 
C) 12.8 million 
D) 6.4 million 
A) 3.2 billion 
B) 12.5 million 
C) 12.8 million 
D) 6.4 million

Question 5

The sequence 5' CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 3' represents a ______________.

Accepted Answer

A) fragment 
B) complex sequence 
C) molecule of mRNA 
D) simple sequence repeat 
A) fragment 
B) complex sequence 
C) molecule of mRNA 
D) simple sequence repeat

Question 6

Recombination frequency between genes can used to generate a

Accepted Answer

A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map. 
A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map.

Question 7

All of the RNA present in a cell or tissue at a specific time is called the

Accepted Answer

A) proteome. 
B) spliceosome. 
C) nucleosome. 
D) RNA motif. 
E) transcriptomE. 
A) proteome. 
B) spliceosome. 
C) nucleosome. 
D) RNA motif. 
E) transcriptomE.

Question 8

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Accepted Answer

A) synteny. 
B) exosymbiosis. 
C) endosymbiosis. 
D) draft sequencing of the proteomes of the mitochondria and chloroplasts by the nucleosome. 
E) contiguous base pairing. 
A) synteny. 
B) exosymbiosis. 
C) endosymbiosis. 
D) draft sequencing of the proteomes of the mitochondria and chloroplasts by the nucleosome. 
E) contiguous base pairing.

Question 9

Draft sequences have

Accepted Answer

A) many gaps in regions of highly repetitive DNA. 
B) less than 1 error in 10,000 nucleotides. 
C) been found in various proteomes across the eukaryote life forms. 
D) been produced by alternative splicing. 
E) several problems,the main one being their contiguous DNA fragments. 
A) many gaps in regions of highly repetitive DNA. 
B) less than 1 error in 10,000 nucleotides. 
C) been found in various proteomes across the eukaryote life forms. 
D) been produced by alternative splicing. 
E) several problems,the main one being their contiguous DNA fragments.

Question 10

A pharmaceutical company is trying to develop a new drug to help combat a rare disease.To facilitate the identification of new drug targets,they could

Accepted Answer

A) search the sequenced human genome for mutations involved in the development of the disease,and design drugs that bind to the mutated proteins. 
B) employ protein microarray technology to evaluate the binding of drugs to various proteins. 
C) test new drugs in transgenic organisms that display disease characteristics. 
D) use antibodies to screen a DNA microarray. 
A) search the sequenced human genome for mutations involved in the development of the disease,and design drugs that bind to the mutated proteins. 
B) employ protein microarray technology to evaluate the binding of drugs to various proteins. 
C) test new drugs in transgenic organisms that display disease characteristics. 
D) use antibodies to screen a DNA microarray.

Question 11

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation,which involves

Accepted Answer

A) shotgun cloning. 
B) the alignment of contigs. 
C) the identification of open reading frames. 
D) the construction of a genetic map. 
A) shotgun cloning. 
B) the alignment of contigs. 
C) the identification of open reading frames. 
D) the construction of a genetic map.

Question 12

A transgene is an

Accepted Answer

A) inserted exon. 
B) inserted intron. 
C) inserted nucleosome. 
D) inserted foreign gene. 
E) inserted transcriptomE. 
A) inserted exon. 
B) inserted intron. 
C) inserted nucleosome. 
D) inserted foreign gene. 
E) inserted transcriptomE.

Question 13

Which of the following statements regarding pseudogenes is false?

Accepted Answer

A) Pseudogenes may have some gene-like features such as a promoter and splice sites. 
B) Pseudogenes encode proteins,but the translated proteins are non-functional. 
C) Pseudogenes can provide insight into the evolutionary history of the related functional gene. 
D) Every pseudogene has a similar DNA sequence to some functional gene. 
A) Pseudogenes may have some gene-like features such as a promoter and splice sites. 
B) Pseudogenes encode proteins,but the translated proteins are non-functional. 
C) Pseudogenes can provide insight into the evolutionary history of the related functional gene. 
D) Every pseudogene has a similar DNA sequence to some functional gene.

Question 14

In vertebrates,the family of myogenic regulatory factors (MFRs)plays a major role in muscle development.This family consists of four related genes,including MyoD,MRF4,myogenin,and myf5,each of which have distinct,but overlapping functions.Interestingly,this gene family is represented by only a single gene called nautilus in Drosophila.You want to determine if nautilus functions as the sum of the vertebrate factors,or rather,if it functions in a manner similar to that of one particular gene.Eventually,you plan to examine the loss-of-function phenotype of nautilus mutants.However,first you should

Accepted Answer

A) compare the DNA and protein sequences of all the genes to determine if nautilus is more closely related to one MRF than another. 
B) perform a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) compare the proteome of a cell expressing nautilus to the proteomes of cells expressing each of the MRFs in turn. 
D) generate four transgenic Drosophila strains that express the MRFs. 
A) compare the DNA and protein sequences of all the genes to determine if nautilus is more closely related to one MRF than another. 
B) perform a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) compare the proteome of a cell expressing nautilus to the proteomes of cells expressing each of the MRFs in turn. 
D) generate four transgenic Drosophila strains that express the MRFs.

Question 15

Conserved arrangements of segments of DNA in related genomes are referred to as

Accepted Answer

A) synteny. 
B) homology. 
C) analogous DNA. 
D) a contig. 
E) a comparative genomE. 
A) synteny. 
B) homology. 
C) analogous DNA. 
D) a contig. 
E) a comparative genomE.

Question 16

To avoid confusion,and to allow ease of data interruption,researchers working on cloned DNA from the same species use

Accepted Answer

A) restriction fragment length polymorphisms. 
B) shotgun sequencing. 
C) sequenced-tagged sites. 
D) clone by clone sequencing. 
E) consensus sequencing. 
A) restriction fragment length polymorphisms. 
B) shotgun sequencing. 
C) sequenced-tagged sites. 
D) clone by clone sequencing. 
E) consensus sequencing.

Question 17

In the early 1980s,a number of clones encoding highly-related forms of actin were isolated from a human cDNA library.Given the information that (i)the restriction enzyme maps of the coding regions were dissimilar,and (ii)each clone contained sufficient coding region to encode all or most of an entire actin gene,you would conclude that

Accepted Answer

A) multiple actin genes arose as a result of a segmental duplication. 
B) the various forms of actin are a result of alternative splicing. 
C) actin proteins are encoded by genes found in a tandem cluster. 
D) actin proteins are encoded by a multigene family. 
A) multiple actin genes arose as a result of a segmental duplication. 
B) the various forms of actin are a result of alternative splicing. 
C) actin proteins are encoded by genes found in a tandem cluster. 
D) actin proteins are encoded by a multigene family.

Question 18

Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?

Accepted Answer

A) Segmental duplications are inherently repetitive. 
B) Segmental duplications contain large numbers of LINEs,which interfere with sequence annotation. 
C) Segmental duplications interfere with BLAST analysis. 
D) Segmental duplications are often found in areas of constitutive heterochromatin. 
A) Segmental duplications are inherently repetitive. 
B) Segmental duplications contain large numbers of LINEs,which interfere with sequence annotation. 
C) Segmental duplications interfere with BLAST analysis. 
D) Segmental duplications are often found in areas of constitutive heterochromatin.

Question 19

Following transcription of eukaryotic genes,introns are removed and exons are spliced together.This process is referred to as______.

Accepted Answer

A) translation 
B) splicing 
C) mRNA modification 
D) coupling 
A) translation 
B) splicing 
C) mRNA modification 
D) coupling

Exam 18: Genomics

A catalog of common genetic variants that occur in humans is called a

Identical copies of genes that can be transcribed simultaneously are called

A private company has been hired by the parliament of ______ to create a data base from pooled medical,genetic,and genealogical information.

Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap),how many sequencing reactions would be needed to determine the complete human genome?

The sequence 5' CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 3' represents a ______________.

Recombination frequency between genes can used to generate a

All of the RNA present in a cell or tissue at a specific time is called the

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Draft sequences have

A pharmaceutical company is trying to develop a new drug to help combat a rare disease.To facilitate the identification of new drug targets,they could

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation,which involves

A transgene is an

Which of the following statements regarding pseudogenes is false?

Conserved arrangements of segments of DNA in related genomes are referred to as

To avoid confusion,and to allow ease of data interruption,researchers working on cloned DNA from the same species use

Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?

Following transcription of eukaryotic genes,introns are removed and exons are spliced together.This process is referred to as______.

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