Question 1

The M:E ratio is determined by examining the relationship between:

Accepted Answer

A) Myeloid precursors and erythroid and lymphoid precursors 
B) Myeloid precursors and lymphoid precursors 
C) Megakaryocytic precursors and nucleated erythroid precursors 
D) All granulocytic precursors and nucleated erythroid precursors 
A) Myeloid precursors and erythroid and lymphoid precursors 
B) Myeloid precursors and lymphoid precursors 
C) Megakaryocytic precursors and nucleated erythroid precursors 
D) All granulocytic precursors and nucleated erythroid precursors

Question 2

All of the following are sites for bone marrow specimen collection except the:

Accepted Answer

A) Tibia 
B) Femur 
C) Sternum 
D) Iliac crest 
A) Tibia 
B) Femur 
C) Sternum 
D) Iliac crest

Question 3

A low M:E ratio in a patient represents what possible process?

Accepted Answer

A) Erythroid hypoplasia 
B) Erythroid hyperplasia 
C) Myeloid hyperplasia 
D) CML 
A) Erythroid hypoplasia 
B) Erythroid hyperplasia 
C) Myeloid hyperplasia 
D) CML

Question 4

A physician performing a bone marrow biopsy on a patient suspected of having acute leukemia was unable to obtain any aspirate but was able to obtain two core biopsies.What is the best way for the laboratorian to use the material obtained?

Accepted Answer

A) Place both core biopsies in formalin and process one immediately;save the other for ancillary tests. 
B) Place one core biopsy in formalin and freeze the second one at -70°C. 
C) Place one core biopsy in formalin after making touch imprints;put the second in saline. 
D) Place both core biopsies in saline;freeze one at 0°C,and process the other immediately. 
A) Place both core biopsies in formalin and process one immediately;save the other for ancillary tests. 
B) Place one core biopsy in formalin and freeze the second one at -70°C. 
C) Place one core biopsy in formalin after making touch imprints;put the second in saline. 
D) Place both core biopsies in saline;freeze one at 0°C,and process the other immediately.

Question 5

Name five distinguishable characteristics that will help differentiate benign lymphoid aggregates and malignant lymphoma.

Accepted Answer

-Benign lymphoid aggregates: nonparatrab

Question 6

The Prussian blue stain is used to stain what element?

Accepted Answer

A) Organelle-associated enzymes 
B) Carbohydrates 
C) Iron 
D) Proteins 
A) Organelle-associated enzymes 
B) Carbohydrates 
C) Iron 
D) Proteins

Question 7

A differential is performed on a bone marrow specimen obtained from a patient suspected of having CML in blast crisis.The results are as follows: 45% blasts,13% metamyelocytes,18% myelocytes,10% promyelocytes,8% bands,2% segmented neutrophils,1% pronormoblasts,1% basophilic normoblasts,1% polychromatophilic normoblasts,and 1% orthochromatophilic normoblasts.What is the M:E ratio?

Accepted Answer

A) 2:1 
B) 24:1 
C) 12:1 
D) 15:1 
A) 2:1 
B) 24:1 
C) 12:1 
D) 15:1

Question 8

The primary location for bone marrow collection depends on which two factors?

Accepted Answer

A) Age and patient condition 
B) Change in sites of hematopoiesis and cellularity 
C) The M:E ratio and medical history 
D) Age and medical history 
A) Age and patient condition 
B) Change in sites of hematopoiesis and cellularity 
C) The M:E ratio and medical history 
D) Age and medical history

Question 9

What is the overall cellularity range of a bone marrow in a 35-year-old female patient?

Accepted Answer

A) 35-45% 
B) 55-75% 
C) 50-60% 
D) 70-80% 
A) 35-45% 
B) 55-75% 
C) 50-60% 
D) 70-80%

Question 10

Name disorders in which the following should be included in the workup of a hematologic disorder.Explain why they are used.
a.Flow cytometry
b.Cytogenetics
c.Molecular genetics
d.Cytochemical staining

Accepted Answer

Flow cytometry: malignant lymphomas and

Question 11

Identify Prussian blue iron stain results in the following disorders and explain your answers:
a.Iron-deficiency anemia
b.Anemia of chronic disease
c.Thalassemia
d.Sideroblastic anemia

Accepted Answer

Iron-deficiency anemia: decreased;the et

Question 12

A 2-year-old boy is suspected of having leukemia,and a bone marrow examination is requested.From which body site should the bone marrow be collected?

Accepted Answer

A) Superior iliac crest 
B) Vertebrae 
C) Tibia 
D) Sternum 
A) Superior iliac crest 
B) Vertebrae 
C) Tibia 
D) Sternum

Question 13

The presence of which of the following in the bone marrow is diagnostic for sideroblastic anemia?

Accepted Answer

A) Iron-laden macrophages 
B) Sea blue histiocytes 
C) Moderate siderocytes 
D) Ringed sideroblasts 
A) Iron-laden macrophages 
B) Sea blue histiocytes 
C) Moderate siderocytes 
D) Ringed sideroblasts

Question 14

What cells are examined for morphologic characteristics of iron particles in the diagnosis of myelodysplastic syndrome?

Accepted Answer

A) Leukocytes 
B) Erythrocytes 
C) Histiocytes and red cell precursors 
D) Lymphocytes 
A) Leukocytes 
B) Erythrocytes 
C) Histiocytes and red cell precursors 
D) Lymphocytes

Exam 38: Bone Marrow Examination

The M:E ratio is determined by examining the relationship between:

All of the following are sites for bone marrow specimen collection except the:

A low M:E ratio in a patient represents what possible process?

A physician performing a bone marrow biopsy on a patient suspected of having acute leukemia was unable to obtain any aspirate but was able to obtain two core biopsies.What is the best way for the laboratorian to use the material obtained?

Name five distinguishable characteristics that will help differentiate benign lymphoid aggregates and malignant lymphoma.

The Prussian blue stain is used to stain what element?

The primary location for bone marrow collection depends on which two factors?

What is the overall cellularity range of a bone marrow in a 35-year-old female patient?

Name disorders in which the following should be included in the workup of a hematologic disorder.Explain why they are used. a.Flow cytometry b.Cytogenetics c.Molecular genetics d.Cytochemical staining

Identify Prussian blue iron stain results in the following disorders and explain your answers: a.Iron-deficiency anemia b.Anemia of chronic disease c.Thalassemia d.Sideroblastic anemia

A 2-year-old boy is suspected of having leukemia,and a bone marrow examination is requested.From which body site should the bone marrow be collected?

The presence of which of the following in the bone marrow is diagnostic for sideroblastic anemia?

What cells are examined for morphologic characteristics of iron particles in the diagnosis of myelodysplastic syndrome?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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