Question 1

Sequential activation of serine proteases that induce the formation of insoluble blood proteins occurs in which phase of coagulation?

Accepted Answer

A) Formation of primary platelet plug 
B) Formation of secondary hemostatic plug 
C) Fibrinolysis of existing hemostatic plugs 
D) Inhibition of primary and secondary hemostatic plug formation 
A) Formation of primary platelet plug 
B) Formation of secondary hemostatic plug 
C) Fibrinolysis of existing hemostatic plugs 
D) Inhibition of primary and secondary hemostatic plug formation

Question 2

Formation of a blood clot on the interior surface of an intact (unsevered)vessel is referred to as:

Accepted Answer

A) Blood coagulation 
B) Hemostasis 
C) Thrombosis 
D) Fibrinolysis 
A) Blood coagulation 
B) Hemostasis 
C) Thrombosis 
D) Fibrinolysis

Question 3

Which of the following substances functions to stabilize platelet aggregates in the platelet plug?

Accepted Answer

A) PDGF 
B) Thrombospondin 
C) Factor V receptor 
D) PF4 
A) PDGF 
B) Thrombospondin 
C) Factor V receptor 
D) PF4

Question 4

Which of the following is responsible for the platelet surface negative charge and is found on the surface membrane of the interior channels?

Accepted Answer

A) Dense tubular system 
B) Open canalicular system 
C) Submembranous cytoskeleton 
D) Glycocalyx 
A) Dense tubular system 
B) Open canalicular system 
C) Submembranous cytoskeleton 
D) Glycocalyx

Question 5

After a blood vessel injury,which of the following initiates hemostasis?

Accepted Answer

A) Endothelial communication 
B) Platelet function inhibition 
C) Vasoconstriction 
D) Vasodilation 
A) Endothelial communication 
B) Platelet function inhibition 
C) Vasoconstriction 
D) Vasodilation

Question 6

Which of the following is a role of platelets in secondary hemostasis?

Accepted Answer

A) To provide factors needed for serine protease activation 
B) To initiate cross-linking of the fibrin monomers 
C) To activate thrombin 
D) To initiate contact activation 
A) To provide factors needed for serine protease activation 
B) To initiate cross-linking of the fibrin monomers 
C) To activate thrombin 
D) To initiate contact activation

Question 7

Which of the following defines the strength of a selected agonist?

Accepted Answer

A) Location in which they are derived 
B) Ability to induce the full range of platelet functions 
C) Ability to interact with thromboxane A₂ 
D) Speed by which the platelets become activated 
A) Location in which they are derived 
B) Ability to induce the full range of platelet functions 
C) Ability to interact with thromboxane A₂ 
D) Speed by which the platelets become activated

Question 8

Which of the following represents a normal platelet number and morphology?

Accepted Answer

A) A platelet that is 10 mcM in size with a blood concentration of 200 x 10⁹/L 
B) A platelet that is 80 mcM in size with a blood concentration of 8 x 10⁹/L 
C) A platelet that is 2.5 mcM in size with a blood concentration of 250 x 10⁹/L 
D) A platelet that is 5 mcM in size with a blood concentration of 600 x 10⁹/L 
A) A platelet that is 10 mcM in size with a blood concentration of 200 x 10⁹/L 
B) A platelet that is 80 mcM in size with a blood concentration of 8 x 10⁹/L 
C) A platelet that is 2.5 mcM in size with a blood concentration of 250 x 10⁹/L 
D) A platelet that is 5 mcM in size with a blood concentration of 600 x 10⁹/L

Question 9

During what stage of megakaryocyte development are platelets released into the circulation?

Accepted Answer

A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation 
A) Between stages III and IV 
B) At the end of stage II 
C) During the cycling phase 
D) At the point of proplatelet formation

Question 10

Beginning with the trauma,what is the sequence of events that leads to the formation of a clot (thrombus)?
 .

Accepted Answer

1.Trauma occurs.
2.Subendothelial collag

Question 11

What is the first step in coagulation that occurs after vascular trauma?

Accepted Answer

A) Vasoconstriction at the site of injury 
B) Platelet adhesion to collagen 
C) Platelet activation and shape change 
D) Platelet aggregation to more platelets 
A) Vasoconstriction at the site of injury 
B) Platelet adhesion to collagen 
C) Platelet activation and shape change 
D) Platelet aggregation to more platelets

Question 12

Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.

Accepted Answer

Platelets develop from megakaryocytes. M

Question 13

Secondary hemostasis involves which of the following events to further hemostasis?

Accepted Answer

A) Generation of fibrin 
B) Blood remains a liquid 
C) Fibrinolysis occurs 
D) Inhibition of platelet release reaction 
A) Generation of fibrin 
B) Blood remains a liquid 
C) Fibrinolysis occurs 
D) Inhibition of platelet release reaction

Question 14

What is the typical concentration of platelets in the blood?

Accepted Answer

A) 200-600 × 10⁸/L 
B) 150-440 × 10⁸/L 
C) 150-440 × 10⁹/L 
D) 250-500 × 10⁹/L 
A) 200-600 × 10⁸/L 
B) 150-440 × 10⁸/L 
C) 150-440 × 10⁹/L 
D) 250-500 × 10⁹/L

Question 15

Which function of the endothelial cell keeps cells and macromolecules in vessels and allows nutrient and gas exchange?

Accepted Answer

A) Blood-borne antigens processing 
B) Tissue factor production 
C) Nitric oxide production 
D) Blood/tissue barrier 
A) Blood-borne antigens processing 
B) Tissue factor production 
C) Nitric oxide production 
D) Blood/tissue barrier

Exam 31: Primary Hemostasis

Sequential activation of serine proteases that induce the formation of insoluble blood proteins occurs in which phase of coagulation?

Formation of a blood clot on the interior surface of an intact (unsevered)vessel is referred to as:

Which of the following substances functions to stabilize platelet aggregates in the platelet plug?

Which of the following is responsible for the platelet surface negative charge and is found on the surface membrane of the interior channels?

After a blood vessel injury,which of the following initiates hemostasis?

Which of the following is a role of platelets in secondary hemostasis?

Which of the following defines the strength of a selected agonist?

Which of the following represents a normal platelet number and morphology?

During what stage of megakaryocyte development are platelets released into the circulation?

Beginning with the trauma,what is the sequence of events that leads to the formation of a clot (thrombus)? .

What is the first step in coagulation that occurs after vascular trauma?

Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.

Secondary hemostasis involves which of the following events to further hemostasis?

What is the typical concentration of platelets in the blood?

Which function of the endothelial cell keeps cells and macromolecules in vessels and allows nutrient and gas exchange?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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