Exam 26: Acute Myeloid Leukemias

Which acute leukemia is characterized by a blast population with both myeloid and monocytic markers on the same cell?

According to the WHO classification,when differentiating myelodysplastic syndromes and acute leukemia,acute leukemia's:

What is the definition of acute leukemia,according to the World Health Organization?

Which of the following does not fall into the category of AML as defined by the WHO classification?

How is erythrocyte morphology likely to be described in patients with AML?

Use this case to answer the following questions: A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso.Patient history was unremarkable.Physical examination revealed a palpable liver and spleen.CBC results revealed: WBC count: 12 × 10⁹/L Hb: 8.7 g/dL Hct: 25% Normal indices PLT count: 5 × 10⁹/L Differential: 80% blasts and 15% promyelocytes present Bone marrow findings: hypercellular marrow with 47% myeloblasts present.Nucleated erythroblasts: 22%;promyelocytes: 28%;megakaryopoiesis appears normal. Cytogenetic analysis: t(15,17)present. -Flow cytometry has also been ordered on this patient.Which of the following markers will stain positive in this case?

Use this case to answer the following questions: A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso.Patient history was unremarkable.Physical examination revealed a palpable liver and spleen.CBC results revealed: WBC count: 12 × 10⁹/L Hb: 8.7 g/dL Hct: 25% Normal indices PLT count: 5 × 10⁹/L Differential: 80% blasts and 15% promyelocytes present Bone marrow findings: hypercellular marrow with 47% myeloblasts present.Nucleated erythroblasts: 22%;promyelocytes: 28%;megakaryopoiesis appears normal. Cytogenetic analysis: t(15,17)present. -Which of the following laboratory findings would be most consistent with this clinical picture?

A patient presents with 25% blasts (nonerythroid),34% monocytic cells,and 31% granulocytic cells in the bone marrow.The peripheral blood smear has 10% monocytes.The alpha-naphthyl esterase and chloroacete esterase are positive.What is the probable diagnosis based on these findings?

A patient presents with acute leukemia with blasts identified by a positive CD34,CD13,and CD33.Less than 3% of the blasts stain positive for MPO and SBB.Which category of AML is the most likely diagnosis for this patient?

Which of the following cell markers differentiate AML from ALL?

An acute leukemia patient presents with blast morphology that is of neutrophil lineage with Auer rods and pseudo-Pelger-Huët nuclei,myeloperoxidase,and Sudan Black B.Cytogenetic analysis reveals a t(8;21) ( q22;q22)translocation in the majority of the blasts.Which classification of AML best fits this morphology,immunophenotyping,and cytochemistry?

A bone marrow review on a 15-year-old girl with acute leukemia revealed many blasts with the following characteristics: high N:C ratio,prominent nucleoli,open chromatin pattern,and basophilic cytoplasm.Cytochemical staining revealed negative reactivity with MPO and SBB.Nonspecific esterase was positive.No cytogenetic abnormalities were detected.What is the most likely lineage of the blast cells in question?

Use this case to answer the following questions: A 45-year-old female was evaluated by her physician because she had unexplained bruising on her upper torso.Patient history was unremarkable.Physical examination revealed a palpable liver and spleen.CBC results revealed: WBC count: 12 × 10⁹/L Hb: 8.7 g/dL Hct: 25% Normal indices PLT count: 5 × 10⁹/L Differential: 80% blasts and 15% promyelocytes present Bone marrow findings: hypercellular marrow with 47% myeloblasts present.Nucleated erythroblasts: 22%;promyelocytes: 28%;megakaryopoiesis appears normal. Cytogenetic analysis: t(15,17)present. -What is the most likely diagnosis?

Which of the following differentiates an AL and an MPN?

Predict the typical platelet concentration of a patient with AML.