Exam 25: Myelodysplastic Syndromes

A patient presents with general anemia and rare or no blasts.The bone marrow smear reveals 3% blasts,no Auer rods,and 12% ringed sideroblasts.Which MDS classification is the associated with these findings?

MDS associated with isolated del(5q)frequently shows dysplasia in which cell lineage?

Which of the following is a likely diagnosis in a 55-year-old male with a bone marrow cellularity of 22%?

Explain the International Prognostic Scoring System (IPSS)score system for prognosis and treatment of MDS.

Which of the following tests would help differentiate between MDS/MPN disorders and CML?

Which of the following MDS/MPN classifications includes the immunophenotype CD33,CD13 +,MPO +?

What must be seen in the bone marrow to confirm refractory anemia with ringed sideroblasts?

Which type of cell contains <20 primary granules in the cytoplasm,has a centralized nucleus,and can be found in both AML and MDS?

On which characteristic is the WHO classification system for each subgroup of myelodysplastic syndrome based?

A 58-year-old male visits his physician for extreme fatigue.After conducting a standard investigation,the physician strongly suspects that the patient is suffering from CML.Which of the following lab results would confirm this picture?

Give at least five morphologic indicators of dyserythropoiesis.

Which of the following IPSS scores has the highest survival rate in MDS?

A patient blood smear shows oval macrocytes,a dimorphic population,and basophilic stippling.The peripheral blood also has 6% blasts .What is the presumptive classification based on these findings?

Which of the following laboratory tests would not be helpful in identifying MDS/MPN,U?