Question 1

Which of the following is used to screen for G6PD deficiency?

Accepted Answer

A) Supravital stain 
B) Fluorescent spot test 
C) PB smear 
D) Cytochemical staining 
A) Supravital stain 
B) Fluorescent spot test 
C) PB smear 
D) Cytochemical staining

Question 2

G6PD deficiency was first recognized during the Korean War when which of the following drugs were administered to the soldiers?

Accepted Answer

A) Sulfonamides 
B) Nitrofurans 
C) Analgesics 
D) Antimalarials 
A) Sulfonamides 
B) Nitrofurans 
C) Analgesics 
D) Antimalarials

Question 3

PK deficiency causes which of the following to occur in the erythrocyte?

Accepted Answer

A) Denatured hemoglobin to precipitate 
B) Splenic sequestration of normal erythrocytes 
C) Premature apoptosis from lack of ATP formed 
D) Membrane instability with excessive sodium and calcium influx 
A) Denatured hemoglobin to precipitate 
B) Splenic sequestration of normal erythrocytes 
C) Premature apoptosis from lack of ATP formed 
D) Membrane instability with excessive sodium and calcium influx

Question 4

Which molecule is responsible for the neutralization of harmful peroxides?

Accepted Answer

A) G6P 
B) Glutathione 
C) HK 
D) PK 
A) G6P 
B) Glutathione 
C) HK 
D) PK

Question 5

What is the purpose of the HMP shunt,and why is it important?

Accepted Answer

Its purpose is to maintain an

Question 6

Intrinsic erythrocyte enzyme deficiencies lead to:

Accepted Answer

A) Increased erythrocyte oxidative susceptibility 
B) Exacerbated immune response against erythrocytes 
C) Increased opsonization of erythrocytes 
D) Increased extravascular hemolysis 
A) Increased erythrocyte oxidative susceptibility 
B) Exacerbated immune response against erythrocytes 
C) Increased opsonization of erythrocytes 
D) Increased extravascular hemolysis

Question 7

Why are Heinz bodies seen in G6PD deficiency?

Accepted Answer

Oxidative crises associated wi

Question 8

Pyruvate kinase is responsible for the conversion of:

Accepted Answer

A) NADPH to ATP 
B) Glucose to glucose 6 phosphate 
C) PEP (phosphoenol pyruvate)to pyruvic acid 
D) Pyruvic acid to lactic acid 
A) NADPH to ATP 
B) Glucose to glucose 6 phosphate 
C) PEP (phosphoenol pyruvate)to pyruvic acid 
D) Pyruvic acid to lactic acid

Question 9

Female heterozygotes for G6PD deficiency have one population of cells that is normal and one that is G6PD deficient because:

Accepted Answer

A) There is random inactivation of one X chromosome 
B) There is random inactivation of one Y chromosome. 
C) There is random activation of one X chromosome. 
D) There is random activation of one Y chromosome. 
A) There is random inactivation of one X chromosome 
B) There is random inactivation of one Y chromosome. 
C) There is random activation of one X chromosome. 
D) There is random activation of one Y chromosome.

Question 10

Why are blister cells not seen in PK deficiency?

Accepted Answer

A) Because Heinz bodies are not formed in PK deficiency 
B) Because G6PD deficiency causes hemolysis,and PK does not 
C) Because G6PD deficient erythrocytes are prone to oxidative damage,and PK deficient erythrocytes are not 
D) Because PK deficiency results in the formation of acanthocytes not Heinz bodies 
A) Because Heinz bodies are not formed in PK deficiency 
B) Because G6PD deficiency causes hemolysis,and PK does not 
C) Because G6PD deficient erythrocytes are prone to oxidative damage,and PK deficient erythrocytes are not 
D) Because PK deficiency results in the formation of acanthocytes not Heinz bodies

Question 11

Which of the following can result from a deficiency of pyruvate kinase in the erythrocyte?

Accepted Answer

A) Gain of ATP 
B) Erythrocyte membrane failure with loss of potassium 
C) Sodium and calcium depletion 
D) Overhydration 
A) Gain of ATP 
B) Erythrocyte membrane failure with loss of potassium 
C) Sodium and calcium depletion 
D) Overhydration

Question 12

Which of the following lab tests is used to confirm G6PD deficiency?

Accepted Answer

A) Fluorescent spot test 
B) PB smear 
C) NADP rate reduction test 
D) Reticulocyte count 
A) Fluorescent spot test 
B) PB smear 
C) NADP rate reduction test 
D) Reticulocyte count

Question 13

What are the principles of the following tests?
a.Fluorescent spot test
b.Dye reduction test
c.Ascorbate cyanide test
d.Rate reduction test

Accepted Answer

Fluorescent spot test: Whole blood is ad

Question 14

What morphologic characteristics are found on a blood smear in G6PD deficiency?

Accepted Answer

A) Leukopenia and echinocytes 
B) Thrombocytopenia and reticulocytosis 
C) Reticulocytosis and blister cells 
D) Döhle bodies and Heinz bodies 
A) Leukopenia and echinocytes 
B) Thrombocytopenia and reticulocytosis 
C) Reticulocytosis and blister cells 
D) Döhle bodies and Heinz bodies

Question 15

Class IV G6PD enzymes include which of the following?

Accepted Answer

A) G6PD-Mediterranean 
B) G6PD-B and G6PD-A+ 
C) G6PD-Iowa 
D) G6PD-Canton 
A) G6PD-Mediterranean 
B) G6PD-B and G6PD-A+ 
C) G6PD-Iowa 
D) G6PD-Canton

Question 16

The mode of inheritance for G6PD deficiency is:

Accepted Answer

A) Autosomal recessive 
B) Autosomal dominant 
C) No pattern established 
D) Sex linked 
A) Autosomal recessive 
B) Autosomal dominant 
C) No pattern established 
D) Sex linked

Exam 18: Hemolytic Anemia: Enzyme Deficiencies

Which of the following is used to screen for G6PD deficiency?

G6PD deficiency was first recognized during the Korean War when which of the following drugs were administered to the soldiers?

PK deficiency causes which of the following to occur in the erythrocyte?

Which molecule is responsible for the neutralization of harmful peroxides?

What is the purpose of the HMP shunt,and why is it important?

Intrinsic erythrocyte enzyme deficiencies lead to:

Why are Heinz bodies seen in G6PD deficiency?

Pyruvate kinase is responsible for the conversion of:

Female heterozygotes for G6PD deficiency have one population of cells that is normal and one that is G6PD deficient because:

Why are blister cells not seen in PK deficiency?

Which of the following can result from a deficiency of pyruvate kinase in the erythrocyte?

Which of the following lab tests is used to confirm G6PD deficiency?

What are the principles of the following tests? a.Fluorescent spot test b.Dye reduction test c.Ascorbate cyanide test d.Rate reduction test

What morphologic characteristics are found on a blood smear in G6PD deficiency?

Class IV G6PD enzymes include which of the following?

The mode of inheritance for G6PD deficiency is:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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