Exam 14: Thalassemia

Choose the thalassemia with the best prognosis from the following choices.

Thalassemia differs from hemoglobinopathies by what characteristic?

What is the treatment of choice for thalassemias?

What is the typical electrophoresis pattern in each of the following disorders? a.α-thalassemia minor b.Hgb H disease c.β-thalassemia major d.β-thalassemia minor

What test could provide the diagnosis differential for β-thalassemia minor and iron deficiency?

Correlate the mutation type to each of the following disorders: a.α-thalassemia major b.β-thalassemia major c.α- thalassemia silent carrier

What is another name for the phenotype of α-thalassemia major?

a-thalassemia major results from deletion in _____ alleles of the alpha chain gene.

A fusion of delta and beta globin chains produces which of the following hemoglobins?

A promoter mutation of a globin chain gene in thalassemia has which effect on the globin chain?

A physician diagnoses a patient with iron-deficiency anemia and begins treatment with iron supplementation.He scheduled a repeat appointment in six months that included routine blood work.Her blood work at this repeat appointment indicates a microcytic normochromic picture with elevated iron levels.Based on these findings,what should the doctor do next?

List the predominating hemoglobins in each of the following disorders: a.Hgb H disease b.α-thalassemia minor c.β-thalassemia major d.β-thalassemia intermedia