Question 1

A high concentration of H+ ions will have what kind of effect on the oxygen dissociation curve?

Accepted Answer

A) A shift to the left 
B) No effect on the oxygen dissociation curve 
C) A shift to the right 
D) Cannot be determined based on information given 
A) A shift to the left 
B) No effect on the oxygen dissociation curve 
C) A shift to the right 
D) Cannot be determined based on information given

Question 2

Which of the following is an expression of the oxygen affinity of hemoglobin?

Accepted Answer

A) Oxyhemoglobin 
B) Deoxyhemoglobin 
C) PCO₂ 
D) P50 
A) Oxyhemoglobin 
B) Deoxyhemoglobin 
C) PCO₂ 
D) P50

Question 3

Which of the following blood vessels have the highest pO₂?

Accepted Answer

A) Pulmonary arteries 
B) Pulmonary veins 
C) Capillary beds 
D) Veins 
A) Pulmonary arteries 
B) Pulmonary veins 
C) Capillary beds 
D) Veins

Question 4

When blood leaves the lungs and reaches the tissues,the PO₂ decreases and the P50 level of O₂ will:

Accepted Answer

A) Decrease 
B) Increase 
C) Equilibrate to the PCO₂ level 
D) Not change 
A) Decrease 
B) Increase 
C) Equilibrate to the PCO₂ level 
D) Not change

Question 5

What two molecules condense to begin heme synthesis?

Accepted Answer

A) Iron and protoporphyrin IX 
B) Ferrochelatase and ALA dehydrase 
C) Succinyl CoA and glycine 
D) PBG deaminase and ALA dehydrase 
A) Iron and protoporphyrin IX 
B) Ferrochelatase and ALA dehydrase 
C) Succinyl CoA and glycine 
D) PBG deaminase and ALA dehydrase

Question 6

High concentrations of heme would cause which of the following?

Accepted Answer

A) A decrease in the synthesis of ALA 
B) An increase in globin chain production 
C) A decrease in globin chain production 
D) An increase in ferrochelatase 
A) A decrease in the synthesis of ALA 
B) An increase in globin chain production 
C) A decrease in globin chain production 
D) An increase in ferrochelatase

Question 7

What element is central to all the structures of a hemoglobin molecule?

Accepted Answer

A) Nitrogen 
B) Iron 
C) Water 
D) Oxygen 
A) Nitrogen 
B) Iron 
C) Water 
D) Oxygen

Question 8

Which abnormal hemoglobin contains a molecule of carbon monoxide?

Accepted Answer

A) Carboxyhemoglobin 
B) Methemoglobin 
C) Sulfhemoglobin 
D) Deoxyhemoglobin 
A) Carboxyhemoglobin 
B) Methemoglobin 
C) Sulfhemoglobin 
D) Deoxyhemoglobin

Question 9

Which of the following is considered a normal hemoglobin concentration in an adult?

Accepted Answer

A) 9.1 g/dL 
B) 1.8 g/dL 
C) 21.2 g/dL 
D) 14.8 g/dL 
A) 9.1 g/dL 
B) 1.8 g/dL 
C) 21.2 g/dL 
D) 14.8 g/dL

Question 10

An anemic patient has increased serum bilirubin.Which of the following laboratory test results would indicate intravascular hemolysis in a patient?

Accepted Answer

A) Increased methemalbumin 
B) Increased haptoglobin 
C) Decreased hemopexin-heme complex 
D) Decreased   dimers 
A) Increased methemalbumin 
B) Increased haptoglobin 
C) Decreased hemopexin-heme complex 
D) Decreased   dimers

Question 11

Choose the hemoglobin that has the highest oxygen affinity.

Accepted Answer

A) Hb A 
B) Hb F 
C) Methemoglobin 
D) Sulfhemoglobin 
A) Hb A 
B) Hb F 
C) Methemoglobin 
D) Sulfhemoglobin

Question 12

An elevated hemoglobin A1C indicates that:

Accepted Answer

A) The patient has an elevated hemoglobin. 
B) The patient is anemic. 
C) The patient's RBCs have been exposed to an elevated blood glucose for a prolonged period of time. 
D) The patient's RBCs need glucose. 
A) The patient has an elevated hemoglobin. 
B) The patient is anemic. 
C) The patient's RBCs have been exposed to an elevated blood glucose for a prolonged period of time. 
D) The patient's RBCs need glucose.

Question 13

Which non-alpha-globin chain composes the predominating normal hemoglobin in adults?

Accepted Answer

A) Gamma 
B) Delta 
C) Beta 
D) Zeta 
A) Gamma 
B) Delta 
C) Beta 
D) Zeta

Question 14

How is globin chain production regulated in the body?

Accepted Answer

A) By regulating the amount of heme produced 
B) By regulating the amount of iron incorporated into the heme moiety 
C) By regulating the number of RBCs produced 
D) By regulating the rate of transcription for protein synthesis 
A) By regulating the amount of heme produced 
B) By regulating the amount of iron incorporated into the heme moiety 
C) By regulating the number of RBCs produced 
D) By regulating the rate of transcription for protein synthesis

Question 15

Which of the following conditions produces a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100°F;normal blood pH: 7.35-7.45. )

Accepted Answer

A) A body temperature of 102°F 
B) A high 2,3-BPG concentration 
C) A blood pH of 7.31 
D) High PO₂ 
A) A body temperature of 102°F 
B) A high 2,3-BPG concentration 
C) A blood pH of 7.31 
D) High PO₂

Question 16

To regulate the amount of heme produced,what enzyme must be regulated?

Accepted Answer

A) ALAS 
B) PBG deaminase 
C) Uroporphyrinogen III 
D) Ferrochelatase 
A) ALAS 
B) PBG deaminase 
C) Uroporphyrinogen III 
D) Ferrochelatase

Question 17

Which of the following abnormal hemoglobins is formed when iron is in the ferric state?

Accepted Answer

A) Oxyhemoglobin 
B) Carboxyhemoglobin 
C) Methemoglobin 
D) Sulfhemoglobin 
A) Oxyhemoglobin 
B) Carboxyhemoglobin 
C) Methemoglobin 
D) Sulfhemoglobin

Question 18

The majority of carbon dioxide is transported in the body:

Accepted Answer

A) By dissolving in plasma. 
B) As carbonic acid. 
C) By binding to hemoglobin. 
D) As methemoglobin 
A) By dissolving in plasma. 
B) As carbonic acid. 
C) By binding to hemoglobin. 
D) As methemoglobin

Question 19

During extravascular hemolysis,which of the following hemoglobin components are physiologically recycled?

Accepted Answer

A) Iron and heme 
B) Haptoglobin and heme 
C) Iron and globin 
D) Heme and globin 
A) Iron and heme 
B) Haptoglobin and heme 
C) Iron and globin 
D) Heme and globin

Question 20

Which of the following is a laboratory test that can be used to identify the occurrence of intravascular hemolysis?

Accepted Answer

A) Prussian blue stain of renal tubular cells 
B) Nitric oxide concentration 
C) Chloride shift 
D) Isoelectric focusing 
A) Prussian blue stain of renal tubular cells 
B) Nitric oxide concentration 
C) Chloride shift 
D) Isoelectric focusing

Exam 6: Hemoglobin

A high concentration of H+ ions will have what kind of effect on the oxygen dissociation curve?

Which of the following is an expression of the oxygen affinity of hemoglobin?

Which of the following blood vessels have the highest pO₂?

When blood leaves the lungs and reaches the tissues,the PO₂ decreases and the P50 level of O₂ will:

What two molecules condense to begin heme synthesis?

High concentrations of heme would cause which of the following?

What element is central to all the structures of a hemoglobin molecule?

Which abnormal hemoglobin contains a molecule of carbon monoxide?

Which of the following is considered a normal hemoglobin concentration in an adult?

An anemic patient has increased serum bilirubin.Which of the following laboratory test results would indicate intravascular hemolysis in a patient?

Choose the hemoglobin that has the highest oxygen affinity.

An elevated hemoglobin A1C indicates that:

Which non-alpha-globin chain composes the predominating normal hemoglobin in adults?

How is globin chain production regulated in the body?

Which of the following conditions produces a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100°F;normal blood pH: 7.35-7.45. )

To regulate the amount of heme produced,what enzyme must be regulated?

Which of the following abnormal hemoglobins is formed when iron is in the ferric state?

The majority of carbon dioxide is transported in the body:

During extravascular hemolysis,which of the following hemoglobin components are physiologically recycled?

Which of the following is a laboratory test that can be used to identify the occurrence of intravascular hemolysis?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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