Question 1

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane?

Accepted Answer

A) Tropomodulin 
B) Troponyosin 
C) Ankyrin 
D) Band 3 
A) Tropomodulin 
B) Troponyosin 
C) Ankyrin 
D) Band 3

Question 2

A blood sample has an elevated bilirubin,low haptoglobin,and low hemopexin.What is the most likely reason for this?

Accepted Answer

A) Increased extravascular hemolysis 
B) Hypersplenism 
C) Ineffective erythropoiesis 
D) Increased intravascular hemolysis 
A) Increased extravascular hemolysis 
B) Hypersplenism 
C) Ineffective erythropoiesis 
D) Increased intravascular hemolysis

Question 3

Explain how EPO regulates RBC production.

Accepted Answer

Erythropoiesis is governed by a negative

Question 4

All of the following proteins interact with spectrin in the RBC membrane except:

Accepted Answer

A) Glycophorin A 
B) Ankyrin 
C) Protein 4.1 
D) Actin 
A) Glycophorin A 
B) Ankyrin 
C) Protein 4.1 
D) Actin

Question 5

What contributes to the RBC cell's membrane integrity?

Accepted Answer

A) Skeletal proteins 
B) Glycolytic pathway 
C) 2,3-BPG 
D) Methemoglobin reductase 
A) Skeletal proteins 
B) Glycolytic pathway 
C) 2,3-BPG 
D) Methemoglobin reductase

Question 6

Energy metabolism of the erythrocyte is achieved primarily through which of the following?

Accepted Answer

A) Aerobic glycolysis 
B) Anaerobic glycolysis 
C) Asexual replication 
D) Mitosis 
A) Aerobic glycolysis 
B) Anaerobic glycolysis 
C) Asexual replication 
D) Mitosis

Question 7

Describe the nuclear and cytoplasmic morphologic changes in erythrocytes during maturation.

Accepted Answer

As erythrocytes mature,the N:C ratios de

Question 8

Explain the effect of the following on RBC survival.
a.An absence of G6PD
b.An absence of PK
c.A defect in spectrin
d.A defect in ankyrin

Accepted Answer

(a)An absence of G6PD: RBC has a shorten

Question 9

Which of the following molecules is a senescence signal when it is exposed on the outer leaflet of the erythrocyte?

Accepted Answer

A) Band 3 
B) Ankyrin 
C) Phosphatidylethanolamine (P
E)  
D) Phosphatidylserine (PS) 
A) Band 3 
B) Ankyrin 
C) Phosphatidylethanolamine (P
E)  
D) Phosphatidylserine (PS)

Question 10

Predict the results of erythropoietin in a patient with hypoxia.

Accepted Answer

A) It will be increased. 
B) It will be normal. 
C) It will be decreased. 
D) This cannot be determined. 
A) It will be increased. 
B) It will be normal. 
C) It will be decreased. 
D) This cannot be determined.

Question 11

Which major integral protein is used in the mechanism to transport the chloride-bicarbonate exchange?

Accepted Answer

A) Glucose transporter 
B) Anion exchange protein 
C) Ankyrin 
D) Adducing 
A) Glucose transporter 
B) Anion exchange protein 
C) Ankyrin 
D) Adducing

Question 12

What element or property contributes to the normal shape of the RBC?

Accepted Answer

A) Sodium 
B) Spectrin tetramer 
C) Calcium 
D) Magnesium 
A) Sodium 
B) Spectrin tetramer 
C) Calcium 
D) Magnesium

Question 13

Which of the following "marks" the RBC as senescent?

Accepted Answer

A) A cluster of band 3 proteins on the RBC membrane 
B) An RBC with denatured hemoglobin on the RBC membrane 
C) An elongated RBC 
D) Hyperphosphorylation of integral proteins 
A) A cluster of band 3 proteins on the RBC membrane 
B) An RBC with denatured hemoglobin on the RBC membrane 
C) An elongated RBC 
D) Hyperphosphorylation of integral proteins

Question 14

What effect would a deficiency in G6PD have on RBC survival?

Accepted Answer

A) It would increase the survival of the RBCs. 
B) It would decrease the survival of the RBCs. 
C) It would have no effect on the survival of the RBCs. 
D) This cannot be determined. 
A) It would increase the survival of the RBCs. 
B) It would decrease the survival of the RBCs. 
C) It would have no effect on the survival of the RBCs. 
D) This cannot be determined.

Question 15

Which part of the RBC membrane is essential for transporting proteins and anions across the membrane?

Accepted Answer

A) Lipids 
B) Integral proteins 
C) Peripheral proteins 
D) Skeletal proteins 
A) Lipids 
B) Integral proteins 
C) Peripheral proteins 
D) Skeletal proteins

Question 16

Choose the correct order of normoblastic maturation from least mature to most mature.

Accepted Answer

A) Erythrocyte,reticulocyte,polychromatophilic normoblast,orthochromatic normoblast,basophilic normoblast,pronormoblast 
B) Pronormoblast,basophilic normoblast,polychromatophilic normoblast,orthochromatic normoblast,reticulocyte,erythrocyte 
C) Basophilic normoblast,pronormoblast,polychromatophilic normoblast,orthochromatic normoblast,erythrocyte 
D) Pronormoblast,polychromatophilic normoblast,orthochromatic normoblast,reticulocyte,erythrocyte 
A) Erythrocyte,reticulocyte,polychromatophilic normoblast,orthochromatic normoblast,basophilic normoblast,pronormoblast 
B) Pronormoblast,basophilic normoblast,polychromatophilic normoblast,orthochromatic normoblast,reticulocyte,erythrocyte 
C) Basophilic normoblast,pronormoblast,polychromatophilic normoblast,orthochromatic normoblast,erythrocyte 
D) Pronormoblast,polychromatophilic normoblast,orthochromatic normoblast,reticulocyte,erythrocyte

Question 17

Which of the following best correlates with an increased reticulocyte count?

Accepted Answer

A) An increased bilirubin 
B) The presence of schistocytes in the peripheral blood smear 
C) Increased polychromasia on the peripheral blood smear 
D) Anisocytosis and poikilocytosis 
A) An increased bilirubin 
B) The presence of schistocytes in the peripheral blood smear 
C) Increased polychromasia on the peripheral blood smear 
D) Anisocytosis and poikilocytosis

Exam 5: The Erythrocyte

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane?

A blood sample has an elevated bilirubin,low haptoglobin,and low hemopexin.What is the most likely reason for this?

Explain how EPO regulates RBC production.

All of the following proteins interact with spectrin in the RBC membrane except:

What contributes to the RBC cell's membrane integrity?

Energy metabolism of the erythrocyte is achieved primarily through which of the following?

Describe the nuclear and cytoplasmic morphologic changes in erythrocytes during maturation.

Explain the effect of the following on RBC survival. a.An absence of G6PD b.An absence of PK c.A defect in spectrin d.A defect in ankyrin

Which of the following molecules is a senescence signal when it is exposed on the outer leaflet of the erythrocyte?

Predict the results of erythropoietin in a patient with hypoxia.

Which major integral protein is used in the mechanism to transport the chloride-bicarbonate exchange?

What element or property contributes to the normal shape of the RBC?

Which of the following "marks" the RBC as senescent?

What effect would a deficiency in G6PD have on RBC survival?

Which part of the RBC membrane is essential for transporting proteins and anions across the membrane?

Choose the correct order of normoblastic maturation from least mature to most mature.

Which of the following best correlates with an increased reticulocyte count?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

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