Question 1

Which of the following is a mechanism of apoptosis in hematopoiesis?

Accepted Answer

A) Expansion of B cell clonal populations in response to infection 
B) Elimination of PMNs and eosinophils after an inflammatory response 
C) Production of RBCs in response to anemia 
D) Progression of acute leukemias 
A) Expansion of B cell clonal populations in response to infection 
B) Elimination of PMNs and eosinophils after an inflammatory response 
C) Production of RBCs in response to anemia 
D) Progression of acute leukemias

Question 2

Predict the effect of p16 on the cell cycle of dividing cells.

Accepted Answer

A) Increases cell cycle progression 
B) Decreases cell cycle progression 
C) Causes no change in the cell cycle progression 
D) Initiates apoptosis 
A) Increases cell cycle progression 
B) Decreases cell cycle progression 
C) Causes no change in the cell cycle progression 
D) Initiates apoptosis

Question 3

The point in the cell cycle after which cell division is complete but before the next round of DNA synthesis is:

Accepted Answer

A) The G₂ phase 
B) The G0 phase 
C) The G₁ phase 
D) The R phase 
A) The G₂ phase 
B) The G0 phase 
C) The G₁ phase 
D) The R phase

Question 4

All of the following are potential proto-oncogenes except:

Accepted Answer

A) Proteins that function as growth factor receptors 
B) Proteins that bind DNA 
C) Growth factors 
D) Proteins that neutralize growth factor receptors 
A) Proteins that function as growth factor receptors 
B) Proteins that bind DNA 
C) Growth factors 
D) Proteins that neutralize growth factor receptors

Question 5

Structurally abnormal proteins can be eliminated from the body by tagging them with _________ and sending them to the __________.

Accepted Answer

A) Caspase;apoptosis pathway 
B) Ubiquitin;proteosome 
C) Cyclins;necrosis pathway 
D) CDKs;apoptosis pathway 
A) Caspase;apoptosis pathway 
B) Ubiquitin;proteosome 
C) Cyclins;necrosis pathway 
D) CDKs;apoptosis pathway

Question 6

In which phase of mitosis do the chromosomes align on opposite poles of the cell?

Accepted Answer

A) Prophase 
B) Metaphase 
C) Anaphase and telophase 
D) Interphase 
A) Prophase 
B) Metaphase 
C) Anaphase and telophase 
D) Interphase

Question 7

List three ways in which the caspase pathway can be activated.Explain the role of each,and indicate which arm of the caspase pathway will be activated.

Accepted Answer

The extrinsic pathway of apoptosis is tr

Question 8

Which cyclin component is predominant in the G₁ phase of the cell cycle?

Accepted Answer

A) Cyclin A 
B) Cyclin B1 
C) Cyclin E 
D) Cyclin D 
A) Cyclin A 
B) Cyclin B1 
C) Cyclin E 
D) Cyclin D

Question 9

The sections of a gene that contain the coding sequences for the final protein product are:

Accepted Answer

A) Exons 
B) Introns 
C) UTRs 
D) Nucleosomes 
A) Exons 
B) Introns 
C) UTRs 
D) Nucleosomes

Question 10

In which phase of the cell cycle is a cell quiescent?

Accepted Answer

A) The G₁ phase 
B) The G0 phase 
C) The R phase 
D) The S phase 
A) The G₁ phase 
B) The G0 phase 
C) The R phase 
D) The S phase

Question 11

List the four major phospholipids found in the plasma membrane of hematopoietic cells,and explain their unique distribution.

Accepted Answer

The four major phospholipids that are fo

Question 12

Apoptosis plays a role in human development in all of the following except:

Accepted Answer

A) Removal of interdigital webs of the hands and feet 
B) Formation of the blood vessels and the gastrointestinal tract 
C) Differentiation (divergence)of mast cells and basophils 
D) Selection of appropriate T and B lymphocyte clones 
A) Removal of interdigital webs of the hands and feet 
B) Formation of the blood vessels and the gastrointestinal tract 
C) Differentiation (divergence)of mast cells and basophils 
D) Selection of appropriate T and B lymphocyte clones

Question 13

Which of the following are apoptosis activators?

Accepted Answer

A) BCL-2 
B) Mcl-1 
C) Bcl-XL 
D) Bak 
A) BCL-2 
B) Mcl-1 
C) Bcl-XL 
D) Bak

Question 14

Which of the following influence the stability of the mRNA and the efficiency of translation?

Accepted Answer

A) Introns 
B) Untranslated regions 
C) Single-nucleotide polymorphisms 
D) Exons 
A) Introns 
B) Untranslated regions 
C) Single-nucleotide polymorphisms 
D) Exons

Question 15

To be considered a true polymorphism,a SNP must occur with a frequency of:

Accepted Answer

A) >1% 
B) >5% 
C) >10% 
D) >25% 
A) >1% 
B) >5% 
C) >10% 
D) >25%

Question 16

Describe the apoptotic pathway.

Accepted Answer

Death receptor binding of death receptor

Question 17

Which phospholipids are predominantly found in the inner layer of the lipid bilayer?

Accepted Answer

A) Phosphatidylethanolamine and phosphatidylcholine 
B) Phosphatidylethanolamine and phosphatidylserine 
C) Phosphatidylserine and sphingomyelin 
D) Phosphatidylcholine and sphingomyelin 
A) Phosphatidylethanolamine and phosphatidylcholine 
B) Phosphatidylethanolamine and phosphatidylserine 
C) Phosphatidylserine and sphingomyelin 
D) Phosphatidylcholine and sphingomyelin

Question 18

Malignancies can result from which of the following?

Accepted Answer

A) Accelerated apoptosis 
B) Inhibited apoptosis 
C) Normal occurrence of apoptosis 
D) None of the above 
A) Accelerated apoptosis 
B) Inhibited apoptosis 
C) Normal occurrence of apoptosis 
D) None of the above

Question 19

At which checkpoint would detection of unreplicated DNA strands occur?

Accepted Answer

A) G₁ checkpoint 
B) G₂/M checkpoint 
C) S phase checkpoint 
D) Metaphase checkpoint 
A) G₁ checkpoint 
B) G₂/M checkpoint 
C) S phase checkpoint 
D) Metaphase checkpoint

Question 20

Cdks must be complexed with what molecule to drive one cell to the next cell-cycle stage?

Accepted Answer

A) DNA 
B) Phosphorylating enzymes 
C) mRNA 
D) Cyclin 
A) DNA 
B) Phosphorylating enzymes 
C) mRNA 
D) Cyclin

Exam 2: Cellular Homeostasis

Which of the following is a mechanism of apoptosis in hematopoiesis?

Predict the effect of p16 on the cell cycle of dividing cells.

The point in the cell cycle after which cell division is complete but before the next round of DNA synthesis is:

All of the following are potential proto-oncogenes except:

Structurally abnormal proteins can be eliminated from the body by tagging them with _________ and sending them to the __________.

In which phase of mitosis do the chromosomes align on opposite poles of the cell?

List three ways in which the caspase pathway can be activated.Explain the role of each,and indicate which arm of the caspase pathway will be activated.

Which cyclin component is predominant in the G₁ phase of the cell cycle?

The sections of a gene that contain the coding sequences for the final protein product are:

In which phase of the cell cycle is a cell quiescent?

List the four major phospholipids found in the plasma membrane of hematopoietic cells,and explain their unique distribution.

Apoptosis plays a role in human development in all of the following except:

Which of the following are apoptosis activators?

Which of the following influence the stability of the mRNA and the efficiency of translation?

To be considered a true polymorphism,a SNP must occur with a frequency of:

Describe the apoptotic pathway.

Which phospholipids are predominantly found in the inner layer of the lipid bilayer?

Malignancies can result from which of the following?

At which checkpoint would detection of unreplicated DNA strands occur?

Cdks must be complexed with what molecule to drive one cell to the next cell-cycle stage?

Introduction

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology Laboratory

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Filters

Structurally abnormal proteins can be eliminated from the body by tagging them with _ and sending them to the __.