Question 1

Pyruvate kinase is responsible for the conversion of:

Accepted Answer

A)  NADPH to ATP 
B)  Glucose to glucose 6 phosphate 
C)  PEP (phosphoenol pyruvate) to pyruvic acid 
D)  Pyruvic acid to lactic acid 
A)  NADPH to ATP 
B)  Glucose to glucose 6 phosphate 
C)  PEP (phosphoenol pyruvate) to pyruvic acid 
D)  Pyruvic acid to lactic acid

Question 2

The common erythrocyte enzyme disorder G6PD deficiency results from a gene mutation on which chromosome?

Accepted Answer

A)  23 
B)  9 
C)  X 
D)  Y 
A)  23 
B)  9 
C)  X 
D)  Y

Question 3

How do Heinz bodies differ morphologically from other erythrocyte inclusions?

Accepted Answer

Heinz bodies typically attach to the ery

Question 4

Which of the following lab tests is used to confirm G6PD deficiency?

Accepted Answer

A)  Fluorescent spot test 
B)  PB smear 
C)  NADP rate reduction test 
D)  Reticulocyte count 
A)  Fluorescent spot test 
B)  PB smear 
C)  NADP rate reduction test 
D)  Reticulocyte count

Question 5

The majority of glucose catabolism occurs via the:

Accepted Answer

A)  Hexose monophosphate shunt 
B)  Embden-Meyerhof pathway 
C)  Luebering-Rapoport pathway 
D)  Synthesis of nucleotides 
A)  Hexose monophosphate shunt 
B)  Embden-Meyerhof pathway 
C)  Luebering-Rapoport pathway 
D)  Synthesis of nucleotides

Question 6

The mode of inheritance for G6PD deficiency is:

Accepted Answer

A)  Autosomal recessive 
B)  Autosomal dominant 
C)  No pattern established 
D)  Sex linked 
A)  Autosomal recessive 
B)  Autosomal dominant 
C)  No pattern established 
D)  Sex linked

Question 7

Why are blister cells not seen in PK deficiency?

Accepted Answer

A)  Because Heinz bodies are not formed in PK deficiency 
B)  Because G6PD deficiency causes hemolysis, and PK does not 
C)  Because G6PD deficient erythrocytes are prone to oxidative damage, and PK deficient erythrocytes are not 
D)  Because PK deficiency results in the formation of acanthocytes not Heinz bodies 
A)  Because Heinz bodies are not formed in PK deficiency 
B)  Because G6PD deficiency causes hemolysis, and PK does not 
C)  Because G6PD deficient erythrocytes are prone to oxidative damage, and PK deficient erythrocytes are not 
D)  Because PK deficiency results in the formation of acanthocytes not Heinz bodies

Question 8

PK deficiency causes which of the following to occur in the erythrocyte?

Accepted Answer

A)  Denatured hemoglobin to precipitate 
B)  Splenic sequestration of normal erythrocytes 
C)  Premature apoptosis from lack of ATP formed 
D)  Membrane instability with excessive sodium and calcium influx 
A)  Denatured hemoglobin to precipitate 
B)  Splenic sequestration of normal erythrocytes 
C)  Premature apoptosis from lack of ATP formed 
D)  Membrane instability with excessive sodium and calcium influx

Question 9

Which of the following is used to screen for G6PD deficiency?

Accepted Answer

A)  Supravital stain 
B)  Fluorescent spot test 
C)  PB smear 
D)  Cytochemical staining 
A)  Supravital stain 
B)  Fluorescent spot test 
C)  PB smear 
D)  Cytochemical staining

Question 10

The erythrocyte morphology associated with pyruvate kinase deficiency is:

Accepted Answer

A)  Microcytic, hypochromic 
B)  Macrocytic, hypochromic 
C)  Normocytic, normochromic. 
D)  Normocytic, hypochromic 
A)  Microcytic, hypochromic 
B)  Macrocytic, hypochromic 
C)  Normocytic, normochromic. 
D)  Normocytic, hypochromic

Question 11

Which of the following is the most common RBC enzymopathy?

Accepted Answer

A)  PK 
B)  HK 
C)  G6PD 
D)  GPI 
A)  PK 
B)  HK 
C)  G6PD 
D)  GPI

Question 12

Bite cells are produced during:

Accepted Answer

A)  Removal of Döhle bodies by macrophages 
B)  Passage of RBCs through fibrin strands 
C)  Removal of Holly-Jolly bodies by the spleen 
D)  Removal of Heinz bodies by macrophages 
A)  Removal of Döhle bodies by macrophages 
B)  Passage of RBCs through fibrin strands 
C)  Removal of Holly-Jolly bodies by the spleen 
D)  Removal of Heinz bodies by macrophages

Question 13

Exposure to which of the following does not induce hemolysis from G6PD deficiency?

Accepted Answer

A)  Primaquine 
B)  Fava beans 
C)  Divicine 
D)  Aspirin 
A)  Primaquine 
B)  Fava beans 
C)  Divicine 
D)  Aspirin

Question 14

Why are Heinz bodies seen in G6PD deficiency?

Accepted Answer

Oxidative crises associated wi

Question 15

What poikilocyte is typically seen in PK deficiency?

Accepted Answer

A)  Heinz bodies 
B)  Acanthocytes 
C)  Spherocytes 
D)  Echinocytes 
A)  Heinz bodies 
B)  Acanthocytes 
C)  Spherocytes 
D)  Echinocytes

Question 16

The presence of which poikilocyte in the peripheral blood could indicate G6PD deficiency?

Accepted Answer

A)  Schistocyte 
B)  Spherocyte 
C)  Blister cell 
D)  Elliptocyte 
A)  Schistocyte 
B)  Spherocyte 
C)  Blister cell 
D)  Elliptocyte

Exam 18: Hemolytic Anemia: Enzyme Deficiencies

Pyruvate kinase is responsible for the conversion of:

The common erythrocyte enzyme disorder G6PD deficiency results from a gene mutation on which chromosome?

How do Heinz bodies differ morphologically from other erythrocyte inclusions?

Which of the following lab tests is used to confirm G6PD deficiency?

The majority of glucose catabolism occurs via the:

The mode of inheritance for G6PD deficiency is:

Why are blister cells not seen in PK deficiency?

PK deficiency causes which of the following to occur in the erythrocyte?

Which of the following is used to screen for G6PD deficiency?

The erythrocyte morphology associated with pyruvate kinase deficiency is:

Which of the following is the most common RBC enzymopathy?

Bite cells are produced during:

Exposure to which of the following does not induce hemolysis from G6PD deficiency?

Why are Heinz bodies seen in G6PD deficiency?

What poikilocyte is typically seen in PK deficiency?

The presence of which poikilocyte in the peripheral blood could indicate G6PD deficiency?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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