Question 1

The type of anemia commonly associated with HUS is:

Accepted Answer

A)  Microcytic, hypochromic 
B)  Macrocytic, normochromic 
C)  Normocytic, normochromic 
D)  Microcytic, normochromic 
A)  Microcytic, hypochromic 
B)  Macrocytic, normochromic 
C)  Normocytic, normochromic 
D)  Microcytic, normochromic

Question 2

Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.

Accepted Answer

C. perfringens releases an endotoxin (al

Question 3

Which of the following analytes would be increased in MAHA?

Accepted Answer

A)  BUN 
B)  Haptoglobin 
C)  Creatinine 
D)  Bilirubin 
A)  BUN 
B)  Haptoglobin 
C)  Creatinine 
D)  Bilirubin

Question 4

What features are identified on the peripheral blood smear in TTP?

Accepted Answer

A)  Increase in presence of reticulocytes, nucleated erythrocytes, abundance of schistocytes 
B)  Leukocytosis with left shift, and schistocytes present reticulocytopenia 
C)  Abundance of schistocytes, thrombocytosis, and leukopenia 
D)  Nucleated erythrocytes, Howell-Jolly bodies, and absence of schistocytes 
A)  Increase in presence of reticulocytes, nucleated erythrocytes, abundance of schistocytes 
B)  Leukocytosis with left shift, and schistocytes present reticulocytopenia 
C)  Abundance of schistocytes, thrombocytosis, and leukopenia 
D)  Nucleated erythrocytes, Howell-Jolly bodies, and absence of schistocytes

Question 5

Laboratory testing in DIC helps distinguish this condition from others. Which of the following results would be expected in DIC?

Accepted Answer

A)  PT normal; APTT prolonged; normal D-dimer test; normal fibrinogen 
B)  PT, APTT, and TT prolonged; elevated D-dimer test; decrease in fibrinogen 
C)  Fibrinogen increased; FDP and D-dimer decreased; PT, APTT, and TT prolonged 
D)  PT, APTT, and TT normal; fibrinogen decreased; FDP and D-dimer increased 
A)  PT normal; APTT prolonged; normal D-dimer test; normal fibrinogen 
B)  PT, APTT, and TT prolonged; elevated D-dimer test; decrease in fibrinogen 
C)  Fibrinogen increased; FDP and D-dimer decreased; PT, APTT, and TT prolonged 
D)  PT, APTT, and TT normal; fibrinogen decreased; FDP and D-dimer increased

Question 6

A 7-year-old girl is brought to a physician because she has a swollen hand with an ischemic lesion. The physician suspects a brown recluse spider bite. What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Accepted Answer

A)  Changes in glycophorin on the erythrocyte membrane 
B)  DIC 
C)  Lysis caused by passage through the fibrin clot 
D)  Changes in the permeability of the cell membrane 
A)  Changes in glycophorin on the erythrocyte membrane 
B)  DIC 
C)  Lysis caused by passage through the fibrin clot 
D)  Changes in the permeability of the cell membrane

Question 7

Describe the mechanism that causes the production of schistocytes in microangiopathic hemolytic anemia.

Accepted Answer

Erythrocyte damage is usually the result

Question 8

Which of the following is found to be a factor in TTP?

Accepted Answer

A)  HIV, EBV, influenza 
B)  Shigella species, Salmonella species, Mycoplasma species 
C)  Ticlopidine, penicillin, chemotherapeutic agents 
D)  All of the above 
A)  HIV, EBV, influenza 
B)  Shigella species, Salmonella species, Mycoplasma species 
C)  Ticlopidine, penicillin, chemotherapeutic agents 
D)  All of the above

Question 9

A mother brings her 3-year-old daughter to the emergency department because she is having trouble urinating. The child is not feverish. She has otherwise been healthy except for a bout of diarrhea about 10 days ago. Laboratory test results are as follows:   Based on the history and the laboratory results, what is the most likely diagnosis?

Accepted Answer

A)  DIC 
B)  Bartonella sp. infection 
C)  HUS 
D)  Previous Clostridium sp. infection 
A)  DIC 
B)  Bartonella sp. infection 
C)  HUS 
D)  Previous Clostridium sp. infection

Question 10

A runner is in training for the Chicago Marathon. After his most recent 26 mile run, he notices that his urine was reddish-brown. The next morning, his urine is clear and yellow, but he decided to see his primary care physician. All of the hematology and chemistry results are within the reference range. What is the most likely reason for this scenario?

Accepted Answer

A)  Initial dark color was caused by dehydration. 
B)  This is exercise-induced hemoglobinuria. 
C)  Uric acid crystals were precipitated in the initial urine. 
D)  There is insufficient information to determine the reason. 
A)  Initial dark color was caused by dehydration. 
B)  This is exercise-induced hemoglobinuria. 
C)  Uric acid crystals were precipitated in the initial urine. 
D)  There is insufficient information to determine the reason.

Exam 20: Hemolytic Anemia: Nonimmune Defects

The type of anemia commonly associated with HUS is:

Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.

Which of the following analytes would be increased in MAHA?

What features are identified on the peripheral blood smear in TTP?

Laboratory testing in DIC helps distinguish this condition from others. Which of the following results would be expected in DIC?

A 7-year-old girl is brought to a physician because she has a swollen hand with an ischemic lesion. The physician suspects a brown recluse spider bite. What is the suspected mechanism of erythrocyte damage caused by venom of this spider?

Describe the mechanism that causes the production of schistocytes in microangiopathic hemolytic anemia.

Which of the following is found to be a factor in TTP?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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