Exam 27: Precursor Lymphoid Neoplasms

Cytogenetic analysis confirms the presence of t(1;14). This verifies which of the following types of ALL?

The most common translocation found in childhood B-cell ALL is:

An immunoglobulin (Ig) gene rearrangement can be identified in all of the following acute lymphoblastic leukemias except:

Which of the following sets of markers would be useful for follow-up testing to differentiate B-cell ALL from T-cell ALL?

B-lymphoblasts in ALL exhibit which one of the following markers that is helpful in their identification?

Which markers are found on lymphoblasts?

A patient has been diagnosed with B-cell ALL. Immunophenotyping has been ordered to confirm the subtype. Which marker would help differentiate Pre-B-cell ALL from Pro-B-cell ALL?

A technologist is reviewing a patient's blood smear. She notices that 85% blasts are present but is having a difficult time identifying the lineage. Cytochemical staining is subsequently performed, and the results for MPO, SBB, NSE, and PAS are negative. Based on this information, what is the most likely lineage of the unknown blasts?

Summarize and explain why patients develop the clinical signs and symptoms observed in patients with ALL.

Contrast the clinical and laboratory findings of ALL to LBL.

Which of the following is an expected finding in the peripheral blood smear of an ALL patient?

Which of the following patient populations is most commonly afflicted with ALL?

Name the classifications of ALL and explain how they differ in molecular analysis and immunophenotype.