Question 1

What is the main reason for using an allogeneic stem cell transplant?

Accepted Answer

A)  Cadaver cells are not suitable because of the patient's cytokine treatment. 
B)  Adequate numbers are achieved with this type of transplantation. 
C)  Highly incompatible tissues are found with the other types of transplantation. 
D)  The disease process involves the patient's own stem cells preventing autologous transplant. 
A)  Cadaver cells are not suitable because of the patient's cytokine treatment. 
B)  Adequate numbers are achieved with this type of transplantation. 
C)  Highly incompatible tissues are found with the other types of transplantation. 
D)  The disease process involves the patient's own stem cells preventing autologous transplant.

Question 2

The most important antigens that need to be matched for a successful outcome in stem cell transplants are:

Accepted Answer

A)  ABO 
B)  Rh 
C)  HLA 
D)  Ii 
A)  ABO 
B)  Rh 
C)  HLA 
D)  Ii

Question 3

Following a stem cell transplant, what steps are identified in the evaluation of engraftment of stem cells?

Accepted Answer

A)  Chimerism studies, bone marrow M:E ratio, and cellularity 
B)  CD34 enumeration of peripheral blood and bone marrow cellularity 
C)  Absolute lymphocyte count, chimerism studies, and bone marrow cellularity 
D)  Absolute neutrophil count enumeration, platelet count, and chimerism studies 
A)  Chimerism studies, bone marrow M:E ratio, and cellularity 
B)  CD34 enumeration of peripheral blood and bone marrow cellularity 
C)  Absolute lymphocyte count, chimerism studies, and bone marrow cellularity 
D)  Absolute neutrophil count enumeration, platelet count, and chimerism studies

Question 4

An optimum result of HLA compatibility is based on which of the following matches between the donor and the recipient?

Accepted Answer

A)  Class I and class II antigens 
B)  HLA-A and HLA-B antigens 
C)  HLA-DR, HLA-DP, and HLA-DQ 
D)  HLA-A, HLA-B, and HLA-DR 
A)  Class I and class II antigens 
B)  HLA-A and HLA-B antigens 
C)  HLA-DR, HLA-DP, and HLA-DQ 
D)  HLA-A, HLA-B, and HLA-DR

Question 5

Explain the significance of HLA and ABO antigen compatibility in stem cell transplantation.

Accepted Answer

Compatibility between donor and recipien

Question 6

Which type of transplant does not have a risk of developing GVHD?

Accepted Answer

A)  Autologous transplant 
B)  Allogeneic transplant 
C)  Syngeneic transplant 
A)  Autologous transplant 
B)  Allogeneic transplant 
C)  Syngeneic transplant

Question 7

Stem cells can treat a variety of different disorders because of their ability to:

Accepted Answer

A)  Self-renew 
B)  Give rise to other cells 
C)  Regenerate quickly 
D)  Have immunity against toxic agents 
A)  Self-renew 
B)  Give rise to other cells 
C)  Regenerate quickly 
D)  Have immunity against toxic agents

Question 8

One disadvantage of using autologous stem cells for treatment in a leukemia patient is:

Accepted Answer

A)  The graft-versus-leukemia effect is not possible 
B)  There is increased risk for graft-versus-host disease 
C)  There is not a need for immunosuppression 
D)  The yield of stem cells is low 
A)  The graft-versus-leukemia effect is not possible 
B)  There is increased risk for graft-versus-host disease 
C)  There is not a need for immunosuppression 
D)  The yield of stem cells is low

Question 9

Which of the following best represents the proper order for drug regimen for a SCT patient?

Accepted Answer

A)  Chemotherapy > antihistamine and antiemetic > GM-CSF 
B)  Antihistamine and antiemetic > GM-CSF > chemotherapy 
C)  Chemotherapy > GM-CSF > antihistamine and antiemetic 
D)  GM-CSF > antihistamine and antiemetic > chemotherapy 
A)  Chemotherapy > antihistamine and antiemetic > GM-CSF 
B)  Antihistamine and antiemetic > GM-CSF > chemotherapy 
C)  Chemotherapy > GM-CSF > antihistamine and antiemetic 
D)  GM-CSF > antihistamine and antiemetic > chemotherapy

Question 10

A procedure used to decrease the potential for GVHD in an allogeneic transplant is:

Accepted Answer

A)  Freeze thaw to kill lymphocytes 
B)  Activation of CD4 cells and suppression of CD8 cells 
C)  Purge of CD8 lymphocytes 
D)  Apheresis 
A)  Freeze thaw to kill lymphocytes 
B)  Activation of CD4 cells and suppression of CD8 cells 
C)  Purge of CD8 lymphocytes 
D)  Apheresis

Question 11

The advantages of using cord blood stem cells as the source of HSC are numerous. What can be seen as one of the drawbacks when used in the adult population?

Accepted Answer

A)  The GVL effect is increased. 
B)  Total number of stem cells for adult is reduced in transplant patients. 
C)  Cord blood contains sufficient numbers but is not compatible within ethnic groups. 
D)  The risk of viral contamination is low. 
A)  The GVL effect is increased. 
B)  Total number of stem cells for adult is reduced in transplant patients. 
C)  Cord blood contains sufficient numbers but is not compatible within ethnic groups. 
D)  The risk of viral contamination is low.

Question 12

Engraftment after transplant is determined by short-term evidence of hematopoietic proliferation. What are the peripheral blood absolute cell counts that indicate short-term engraftment?

Accepted Answer

A)  Absolute neutrophil count is more than 100 mcL (µL) and platelet count is more than 50,000 mcL. 
B)  Absolute lymphocyte count is less than 500 mcL, and platelet count is more than 10,000 mcL. 
C)  Neutrophil count is more than 500 mcL, and platelet count is more than 20,000 mcL. 
D)  Neutrophil count is more than 1000 mcL, and the platelet count is more than 10,000 mcL. 
A)  Absolute neutrophil count is more than 100 mcL (µL) and platelet count is more than 50,000 mcL. 
B)  Absolute lymphocyte count is less than 500 mcL, and platelet count is more than 10,000 mcL. 
C)  Neutrophil count is more than 500 mcL, and platelet count is more than 20,000 mcL. 
D)  Neutrophil count is more than 1000 mcL, and the platelet count is more than 10,000 mcL.

Question 13

Explain the detection and significance of chimerisms in stem cell transplantation.

Accepted Answer

The presence of chimerisms indicates com

Question 14

Which of the following diseases can be treated with an allogeneic transplant?

Accepted Answer

A)  Hodgkin lymphoma 
B)  Solid organ tumors 
C)  Non-Hodgkin lymphoma 
D)  Acute leukemia 
A)  Hodgkin lymphoma 
B)  Solid organ tumors 
C)  Non-Hodgkin lymphoma 
D)  Acute leukemia

Question 15

The laboratory professional is not involved in which of following steps associated with SCT?

Accepted Answer

A)  Compatibility testing 
B)  Pretransfusion testing 
C)  Apheresis 
D)  Transfusion of SCT product in patient 
A)  Compatibility testing 
B)  Pretransfusion testing 
C)  Apheresis 
D)  Transfusion of SCT product in patient

Question 16

Explain the graft-versus-leukemia process in stem cell transplantation.

Accepted Answer

Graft-versus-leukemia is a positive cons

Question 17

When the decision is made to undertake the stem cell transplantation process, many laboratories are involved in working for a successful outcome. The MNCs product will go to which laboratories for cell counts and immunotyping?

Accepted Answer

A)  Molecular diagnostic and HLA labs 
B)  Hematology and flow cytometry labs 
C)  Blood bank and HLA labs 
D)  Molecular diagnostics and hematology labs 
A)  Molecular diagnostic and HLA labs 
B)  Hematology and flow cytometry labs 
C)  Blood bank and HLA labs 
D)  Molecular diagnostics and hematology labs

Question 18

Which of the following type of SCT patients has the highest risk of developing GVHD?

Accepted Answer

A)  Syngeneic transplant patients 
B)  Autologous transplant patients 
C)  Allogeneic transplant patients 
D)  Isogeneic transplant patients 
A)  Syngeneic transplant patients 
B)  Autologous transplant patients 
C)  Allogeneic transplant patients 
D)  Isogeneic transplant patients

Question 19

Which of the following agents has the ability to re-emerge in SCT patients on multiple occasions?

Accepted Answer

A)  Streptococcus infection 
B)  Cytomegalovirus infection 
C)  Candidiasis 
D)  Epstein-Barr virus infection 
A)  Streptococcus infection 
B)  Cytomegalovirus infection 
C)  Candidiasis 
D)  Epstein-Barr virus infection

Question 20

Which of the following best represents the correct order of maturation (youngest to most mature) for hematopoiesis?

Accepted Answer

A)  HSC > precursor >committed progenitor 
B)  Precursor >HSC >committed progenitor 
C)  HSC > committed progenitor > precursor 
D)  Committed progenitor >precursor > HSC 
A)  HSC > precursor >committed progenitor 
B)  Precursor >HSC >committed progenitor 
C)  HSC > committed progenitor > precursor 
D)  Committed progenitor >precursor > HSC

Exam 29: Hematopoietic Stem Cell Transplantation

What is the main reason for using an allogeneic stem cell transplant?

The most important antigens that need to be matched for a successful outcome in stem cell transplants are:

Following a stem cell transplant, what steps are identified in the evaluation of engraftment of stem cells?

An optimum result of HLA compatibility is based on which of the following matches between the donor and the recipient?

Explain the significance of HLA and ABO antigen compatibility in stem cell transplantation.

Which type of transplant does not have a risk of developing GVHD?

Stem cells can treat a variety of different disorders because of their ability to:

One disadvantage of using autologous stem cells for treatment in a leukemia patient is:

Which of the following best represents the proper order for drug regimen for a SCT patient?

A procedure used to decrease the potential for GVHD in an allogeneic transplant is:

The advantages of using cord blood stem cells as the source of HSC are numerous. What can be seen as one of the drawbacks when used in the adult population?

Engraftment after transplant is determined by short-term evidence of hematopoietic proliferation. What are the peripheral blood absolute cell counts that indicate short-term engraftment?

Explain the detection and significance of chimerisms in stem cell transplantation.

Which of the following diseases can be treated with an allogeneic transplant?

The laboratory professional is not involved in which of following steps associated with SCT?

Explain the graft-versus-leukemia process in stem cell transplantation.

When the decision is made to undertake the stem cell transplantation process, many laboratories are involved in working for a successful outcome. The MNCs product will go to which laboratories for cell counts and immunotyping?

Which of the following type of SCT patients has the highest risk of developing GVHD?

Which of the following agents has the ability to re-emerge in SCT patients on multiple occasions?

Which of the following best represents the correct order of maturation (youngest to most mature) for hematopoiesis?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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