Exam 35: Thrombophilia

Patients with protein C and/or S deficiencies are at risk for which type of complication?

Antibodies to which component(s) are thought to complex with the phospholipids resulting in antiphospholipid antibody syndrome are:

A patient has been taking Coumadin for a recent thrombophilic episode. He follows up with his physician two weeks after starting this treatment. The physician sees evidence of skin necrosis on the patient. What should the physician do next to investigate this finding?

Which of the following conditions is not associated with an increased tendency for thrombosis?

A patient with thrombophilia has a decreased functional and antigenic activity of protein C. What is the diagnosis?

Failure of protein C to destroy FVa and FVIIIa results in an increase in what hemostatic system alteration?

Which of the following mechanisms can lead to an increased risk of thrombosis?

A patient being treated with heparin therapy has a 65% decrease in platelet count from the baseline count after 6 days of being on the anticoagulant. What is the probable cause of the decrease?

Antithrombin and heparin cofactor II primarily inhibit which of the following factors?

What is the usual adjustment for heparin dosage?

A tendency to favor thrombus formation produced from an imbalance in the major constituents of the hemostatic system is defined as:

When is routine monitoring of LMWH indicated?

How do red thrombi differ from white thrombi?

A patient is admitted to the local hospital with a pulmonary embolus. He was unconscious when admitted to the emergency department. Ultrasound revealed a large clot in the patient's saphenous vein. Thrombolytic therapy is administered, and eventually the patient's condition stabilizes. Laboratory tests are performed at hospital admission; their results follow: PT: 15.5 sec INR: 2.85 APTT: 76 sec Protein C antigen: 14% Protein C functional activity: 18% Molecular studies: FV-R506Q present Based on this information, what is the most probable diagnosis for this patient?

Why are clotting and molecular assays both needed for a diagnosis of APCR?

What are the physiological processes involved in hypercoagulability?

Mutations in which of the following gene(s) lead to hyperhomocysteinemia?

Patients with a DVT are at risk for developing which of the following?