Question 1

Several cytokines are used for clinical purposes. Which three cell lines are primarily increased by the injection of EPO, TPO, and CFU-GM?

Accepted Answer

A)  Lymphocytes, monocytes, and platelets 
B)  Erythrocytes, platelets, and granulocytes 
C)  Monocytes, platelets, and stem cells 
D)  Stem cells, precursor cells, and maturing cells 
A)  Lymphocytes, monocytes, and platelets 
B)  Erythrocytes, platelets, and granulocytes 
C)  Monocytes, platelets, and stem cells 
D)  Stem cells, precursor cells, and maturing cells

Question 2

All of the following are functions of the BM stroma except:

Accepted Answer

A)  Adhesion of hematopoietic precursors 
B)  Cell-to-cell interaction 
C)  Synthesis of cytokines 
D)  Incorporation of essential metals into mature cells 
A)  Adhesion of hematopoietic precursors 
B)  Cell-to-cell interaction 
C)  Synthesis of cytokines 
D)  Incorporation of essential metals into mature cells

Question 3

All of the following are hematopoietic growth factor receptor subgroups except:

Accepted Answer

A)  Unique ligand-specific alpha chains with shared beta chains 
B)  Unique ligand-specific alpha chains that share GP130 
C)  Unique ligand-specific alpha chains with shared gamma chains 
D)  Unique ligand-specific alpha chains with shared zeta chains 
A)  Unique ligand-specific alpha chains with shared beta chains 
B)  Unique ligand-specific alpha chains that share GP130 
C)  Unique ligand-specific alpha chains with shared gamma chains 
D)  Unique ligand-specific alpha chains with shared zeta chains

Question 4

All of the following are characteristics of an optimal hematopoietic microenvironment except:

Accepted Answer

A)  Fibronectin 
B)  Extracellular matrix 
C)  Stromal cells 
D)  Synthetic cytokines 
A)  Fibronectin 
B)  Extracellular matrix 
C)  Stromal cells 
D)  Synthetic cytokines

Question 5

Which of the following is an example of a lineage-specific cytokine?

Accepted Answer

A)  Kit ligand 
B)  CFU-GEMM 
C)  IL-3 
D)  G-CSF 
A)  Kit ligand 
B)  CFU-GEMM 
C)  IL-3 
D)  G-CSF

Question 6

All of the following are key components of hematopoietic differentiation except:

Accepted Answer

A)  The formation of mature blood components with a finite life span 
B)  The differentiation of blood components when exposed to different cytokines 
C)  The commitment to produce blood cells only 
D)  The activation of programmed cell death 
A)  The formation of mature blood components with a finite life span 
B)  The differentiation of blood components when exposed to different cytokines 
C)  The commitment to produce blood cells only 
D)  The activation of programmed cell death

Question 7

All of the following function primarily as multilineage (early acting) growth factors except:

Accepted Answer

A)  IL-4 
B)  GM-CSF 
C)  IL-3 
D)  SCF 
A)  IL-4 
B)  GM-CSF 
C)  IL-3 
D)  SCF

Question 8

An unknown cell is positive for CD34 and negative for CD38, lineage markers, and HLA-DR. Identify the cell.

Accepted Answer

A)  MPP 
B)  Hematopoietic stem cell 
C)  CLP 
D)  CMP 
A)  MPP 
B)  Hematopoietic stem cell 
C)  CLP 
D)  CMP

Question 9

Which component of the BM stroma is responsible for the formation of the ECM?

Accepted Answer

A)  Cytokines 
B)  Fibroblasts 
C)  Osteoclasts 
D)  Collagen 
A)  Cytokines 
B)  Fibroblasts 
C)  Osteoclasts 
D)  Collagen

Question 10

Compare and contrast the HSC and the progenitor cells. How are they similar? How are they different?

Accepted Answer

The hematopoietic stem cell (HSC) has ca

Question 11

Which of the following cells gives rise to the lymphoid and myeloid cells?

Accepted Answer

A)  Committed lymphoid progenitor cell 
B)  Multipotential progenitor cell 
C)  Committed myeloid progenitor cell 
D)  CFU-GEMM 
A)  Committed lymphoid progenitor cell 
B)  Multipotential progenitor cell 
C)  Committed myeloid progenitor cell 
D)  CFU-GEMM

Question 12

All of the following can be formed from CFU-GEMM except:

Accepted Answer

A)  Neutrophil 
B)  Erythrocyte 
C)  Platelet 
D)  Lymphocyte 
A)  Neutrophil 
B)  Erythrocyte 
C)  Platelet 
D)  Lymphocyte

Question 13

Explain the role of stromal cells in the hematopoietic microenvironment.

Accepted Answer

Stromal cells express homing receptors f

Question 14

What property primarily determines the specific targets of hematopoietic growth factors?

Accepted Answer

A)  Unique transcription factors in the target cells 
B)  Unique signaling pathways in the target cells 
C)  Unique receptors in the membranes of the target cells 
D)  Lack of inhibitors to the growth factor in question 
A)  Unique transcription factors in the target cells 
B)  Unique signaling pathways in the target cells 
C)  Unique receptors in the membranes of the target cells 
D)  Lack of inhibitors to the growth factor in question

Question 15

Which term is used to describe all cells antecedent to mature cells of a particular lineage?

Accepted Answer

A)  Progenitor cells 
B)  Stem cells 
C)  Precursor cells 
D)  Maturing cells 
A)  Progenitor cells 
B)  Stem cells 
C)  Precursor cells 
D)  Maturing cells

Exam 4: Hematopoiesis

Several cytokines are used for clinical purposes. Which three cell lines are primarily increased by the injection of EPO, TPO, and CFU-GM?

All of the following are functions of the BM stroma except:

All of the following are hematopoietic growth factor receptor subgroups except:

All of the following are characteristics of an optimal hematopoietic microenvironment except:

Which of the following is an example of a lineage-specific cytokine?

All of the following are key components of hematopoietic differentiation except:

All of the following function primarily as multilineage (early acting) growth factors except:

An unknown cell is positive for CD34 and negative for CD38, lineage markers, and HLA-DR. Identify the cell.

Which component of the BM stroma is responsible for the formation of the ECM?

Compare and contrast the HSC and the progenitor cells. How are they similar? How are they different?

Which of the following cells gives rise to the lymphoid and myeloid cells?

All of the following can be formed from CFU-GEMM except:

Explain the role of stromal cells in the hematopoietic microenvironment.

What property primarily determines the specific targets of hematopoietic growth factors?

Which term is used to describe all cells antecedent to mature cells of a particular lineage?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters