Exam 41: Chromosome Analysis of Hematopoietic and Lymphoid Disorders

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A patient is receiving treatment for Hodgkin lymphoma. Six weeks after cessation of the treatment, a cytogenetic analysis is performed. A structural aberration is found. Name the most probable aberration(s) and explain how these may occur.

(Essay)

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Question 21

Discuss the impact of FISH technology in hematolymphoid disorders and bone marrow transplant recipients.

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Question 22

Which of the following is an appropriate specimen source for cytogenetic analysis?

(Multiple Choice)

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Question 23

A patient is receiving chemotherapy for Hodgkin lymphoma. When the treatment ends, a cytogenetic analysis is ordered to determine whether the treatment was successful. Which of the following would be the most appropriate specimen to collect for this?

(Multiple Choice)

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Question 24

Which of the following terms is used to describe a chromosomal aberration present in a human cell that is a multiple of n?

(Multiple Choice)

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Question 25

Which of the following structural aberrations results in loss of an entire chromosomal arm?

(Multiple Choice)

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Question 26

List at least five indications for performing FISH analysis in patients suspected of having a hematolymphoid disorder.

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Question 27

The cell cycle contains four phases: G1, S, G2, and mitosis. Which phase must be active to study human chromosomes?

(Multiple Choice)

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Question 28

A 3-year-old girl is confirmed to have ALL by immunophenotyping. She is positive for the CALLA antigen. Cytogenetic analysis results indicate the presence of the Philadelphia chromosome. Which of the following applies to her?

(Multiple Choice)

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Question 29

The chromosome abnormality type that results in a daughter cell with an extra chromosome-or trisomy-or a daughter cell with a loss of chromosome is characterized as which of the following?

(Multiple Choice)

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Question 30

A laboratory professional should process a bone marrow aspirate for cytogenetic analysis in a patient with a lymphoma by using which of the following?

(Multiple Choice)

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Question 31

The presence of a chimerism after a bone marrow transplant indicates:

(Multiple Choice)

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Question 32

The first abnormality described in the lymphomas was in Burkitt lymphoma. This first demonstration of a proto-oncogene that was translocated to a location known to be active in B-cell lymphoma, resulting in the activation of the oncogene, was at what heavy chain locus?

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Question 33

Monosomy is an example of:

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Question 34

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Exam 41: Chromosome Analysis of Hematopoietic and Lymphoid Disorders

A patient is receiving treatment for Hodgkin lymphoma. Six weeks after cessation of the treatment, a cytogenetic analysis is performed. A structural aberration is found. Name the most probable aberration(s) and explain how these may occur.

Discuss the impact of FISH technology in hematolymphoid disorders and bone marrow transplant recipients.

Which of the following is an appropriate specimen source for cytogenetic analysis?

A patient is receiving chemotherapy for Hodgkin lymphoma. When the treatment ends, a cytogenetic analysis is ordered to determine whether the treatment was successful. Which of the following would be the most appropriate specimen to collect for this?

Which of the following terms is used to describe a chromosomal aberration present in a human cell that is a multiple of n?

Which of the following structural aberrations results in loss of an entire chromosomal arm?

List at least five indications for performing FISH analysis in patients suspected of having a hematolymphoid disorder.

The cell cycle contains four phases: G1, S, G2, and mitosis. Which phase must be active to study human chromosomes?

A 3-year-old girl is confirmed to have ALL by immunophenotyping. She is positive for the CALLA antigen. Cytogenetic analysis results indicate the presence of the Philadelphia chromosome. Which of the following applies to her?

The chromosome abnormality type that results in a daughter cell with an extra chromosome-or trisomy-or a daughter cell with a loss of chromosome is characterized as which of the following?

A laboratory professional should process a bone marrow aspirate for cytogenetic analysis in a patient with a lymphoma by using which of the following?

The presence of a chimerism after a bone marrow transplant indicates:

The first abnormality described in the lymphomas was in Burkitt lymphoma. This first demonstration of a proto-oncogene that was translocated to a location known to be active in B-cell lymphoma, resulting in the activation of the oncogene, was at what heavy chain locus?

Monosomy is an example of:

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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