Question 1

What growth factor influences the production of the erythrocyte?

Accepted Answer

A)  Transforming growth factor-β 
B)  Interferon-γ 
C)  Erythropoietin 
D)  CFU-E 
A)  Transforming growth factor-β 
B)  Interferon-γ 
C)  Erythropoietin 
D)  CFU-E

Question 2

The deformability of the RBC membrane is attributed to which of the following?

Accepted Answer

A)  Peripheral proteins 
B)  Integral proteins 
C)  Sodium potassium pump 
D)  Glycophorins 
A)  Peripheral proteins 
B)  Integral proteins 
C)  Sodium potassium pump 
D)  Glycophorins

Question 3

Describe the nuclear and cytoplasmic morphologic changes in erythrocytes during maturation.

Accepted Answer

As erythrocytes mature, the N:C ratios d

Question 4

Polychromatophilic erythrocytes are representative of what cell type?

Accepted Answer

A)  Normoblast 
B)  Prorubricyte 
C)  Reticulocyte 
D)  Metarubricyte 
A)  Normoblast 
B)  Prorubricyte 
C)  Reticulocyte 
D)  Metarubricyte

Question 5

The life span of a normal erythrocyte is about:

Accepted Answer

A)  9-11 days 
B)  5-7 days 
C)  120 days 
D)  6 hours 
A)  9-11 days 
B)  5-7 days 
C)  120 days 
D)  6 hours

Question 6

All of the following proteins interact with spectrin in the RBC membrane except:

Accepted Answer

A)  Glycophorin A 
B)  Ankyrin 
C)  Band 4.1 
D)  Actin 
A)  Glycophorin A 
B)  Ankyrin 
C)  Band 4.1 
D)  Actin

Question 7

What is the primary mechanism by which erythropoietin affects RBC production?

Accepted Answer

A)  It expedites the maturation time of RBCs. 
B)  It prevents premature apoptosis of RBCs. 
C)  It stimulates facilitated incorporation of hemoglobin into RBCs. 
D)  It stimulates expulsion of nuclei from nucleated erythrocyte precursors at a quicker rate. 
A)  It expedites the maturation time of RBCs. 
B)  It prevents premature apoptosis of RBCs. 
C)  It stimulates facilitated incorporation of hemoglobin into RBCs. 
D)  It stimulates expulsion of nuclei from nucleated erythrocyte precursors at a quicker rate.

Question 8

Expansion of the inner leaflet of the erythrocyte membrane lipid bilayer by the influx of sodium and water results in the formation of:

Accepted Answer

A)  Echinocytes 
B)  Stomatocytes 
C)  Spherocytes 
D)  Dacrocytes 
A)  Echinocytes 
B)  Stomatocytes 
C)  Spherocytes 
D)  Dacrocytes

Question 9

Which of the following best correlates with an increased reticulocyte count?

Accepted Answer

A)  An increased bilirubin 
B)  The presence of schistocytes in the peripheral blood smear 
C)  Increased polychromasia on the peripheral blood smear 
D)  Anisocytosis and poikilocytosis 
A)  An increased bilirubin 
B)  The presence of schistocytes in the peripheral blood smear 
C)  Increased polychromasia on the peripheral blood smear 
D)  Anisocytosis and poikilocytosis

Question 10

Explain how EPO regulates RBC production.

Accepted Answer

Erythropoiesis is governed by a negative

Question 11

A reticulocyte count is 6%. This result is:

Accepted Answer

A)  Normal 
B)  Increased 
C)  Decreased 
D)  Erroneous 
A)  Normal 
B)  Increased 
C)  Decreased 
D)  Erroneous

Question 12

Explain the effect of the following on RBC survival.
a. An absence of G6PD
b. An absence of PK
c. A defect in spectrin
d. A defect in ankyrin

Accepted Answer

a. An absence of G6PD: RBC has a shorten

Question 13

What analyte can help to differentiate between intravascular and extravascular hemolysis?

Accepted Answer

A)  Hemoglobin 
B)  Bilirubin 
C)  Haptoglobin 
D)  Reticulocytes 
A)  Hemoglobin 
B)  Bilirubin 
C)  Haptoglobin 
D)  Reticulocytes

Question 14

Which pathway produces the energy required for proper RBC function from ~90% of the consumed glucose?

Accepted Answer

A)  Methemoglobin reductase 
B)  Hexose monophosphate shunt 
C)  Glycolytic 
D)  Rapoport-Leubering shunt 
A)  Methemoglobin reductase 
B)  Hexose monophosphate shunt 
C)  Glycolytic 
D)  Rapoport-Leubering shunt

Question 15

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane?

Accepted Answer

A)  Tropomodulin 
B)  Troponyosin 
C)  Ankyrin 
D)  Band 3 
A)  Tropomodulin 
B)  Troponyosin 
C)  Ankyrin 
D)  Band 3

Question 16

What effect would a deficiency in G6PD have on RBC survival?

Accepted Answer

A)  It would increase the survival of the RBCs. 
B)  It would decrease the survival of the RBCs. 
C)  It would have no effect on the survival of the RBCs. 
D)  This cannot be determined. 
A)  It would increase the survival of the RBCs. 
B)  It would decrease the survival of the RBCs. 
C)  It would have no effect on the survival of the RBCs. 
D)  This cannot be determined.

Question 17

The production of 2,3-BPG occurs in which erythrocytic metabolic pathway?

Accepted Answer

A)  Embden-Meyerhof pathway 
B)  Hexose monophosphate shunt 
C)  Rapoport-Luebering shunt 
D)  All of the above 
A)  Embden-Meyerhof pathway 
B)  Hexose monophosphate shunt 
C)  Rapoport-Luebering shunt 
D)  All of the above

Exam 5: The Erythrocyte

What growth factor influences the production of the erythrocyte?

The deformability of the RBC membrane is attributed to which of the following?

Describe the nuclear and cytoplasmic morphologic changes in erythrocytes during maturation.

Polychromatophilic erythrocytes are representative of what cell type?

The life span of a normal erythrocyte is about:

All of the following proteins interact with spectrin in the RBC membrane except:

What is the primary mechanism by which erythropoietin affects RBC production?

Expansion of the inner leaflet of the erythrocyte membrane lipid bilayer by the influx of sodium and water results in the formation of:

Which of the following best correlates with an increased reticulocyte count?

Explain how EPO regulates RBC production.

A reticulocyte count is 6%. This result is:

Explain the effect of the following on RBC survival. a. An absence of G6PD b. An absence of PK c. A defect in spectrin d. A defect in ankyrin

What analyte can help to differentiate between intravascular and extravascular hemolysis?

Which pathway produces the energy required for proper RBC function from ~90% of the consumed glucose?

What protein is the major membrane attachment point of the latticework that laminates the inner lining of the RBC membrane?

What effect would a deficiency in G6PD have on RBC survival?

The production of 2,3-BPG occurs in which erythrocytic metabolic pathway?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

Hemoglobin

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

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