Question 1

Which abnormal hemoglobin contains a molecule of carbon monoxide?

Accepted Answer

A)  Carboxyhemoglobin 
B)  Methemoglobin 
C)  Sulfhemoglobin 
D)  Deoxyhemoglobin 
A)  Carboxyhemoglobin 
B)  Methemoglobin 
C)  Sulfhemoglobin 
D)  Deoxyhemoglobin

Question 2

What are the chain designations for hemoglobin F?

Accepted Answer

A)  α2β2 
B)  α2δ2 
C)  α2γ2  
D)  α2ε2 
A)  α2β2 
B)  α2δ2 
C)  α2γ2  
D)  α2ε2

Question 3

In the complete hemoglobin structure, iron is:

Accepted Answer

A)  Attached to the alpha-globin chains 
B)  Attached to the non-alpha-globin chain 
C)  In the mitochondria 
D)  In the protoporphyrin ring 
A)  Attached to the alpha-globin chains 
B)  Attached to the non-alpha-globin chain 
C)  In the mitochondria 
D)  In the protoporphyrin ring

Question 4

When mutations occur in the globin chains of hemoglobin, what two interactions can be impaired?

Accepted Answer

A)  Stability and hemoglobin-oxygen affinity 
B)  Iron binding and stability 
C)  Heme synthesis and affinity 
D)  Iron regulation and affinity 
A)  Stability and hemoglobin-oxygen affinity 
B)  Iron binding and stability 
C)  Heme synthesis and affinity 
D)  Iron regulation and affinity

Question 5

Which of the following is an expression of the oxygen affinity of hemoglobin?

Accepted Answer

A)  Oxyhemoglobin 
B)  Deoxyhemoglobin 
C)  PCO2 
D)  P50 
A)  Oxyhemoglobin 
B)  Deoxyhemoglobin 
C)  PCO2 
D)  P50

Question 6

Correlate embryonic/fetal hemoglobin production to stages of fetal hematopoiesis.

Accepted Answer

Fetal hematopoiesis:
• Embryonic phase:

Question 7

Which of the following is not a breakdown product of hemoglobin:

Accepted Answer

A)  Globin 
B)  Iron 
C)  Haptoglobin 
D)  Biliverdin 
A)  Globin 
B)  Iron 
C)  Haptoglobin 
D)  Biliverdin

Question 8

An anemic patient has increased serum bilirubin. Which of the following laboratory test results would indicate intravascular hemolysis in a patient?

Accepted Answer

A)  Increased methemalbumin 
B)  Increased haptoglobin 
C)  Decreased hemopexin-heme complex 
D)  Decreased α - β dimers 
A)  Increased methemalbumin 
B)  Increased haptoglobin 
C)  Decreased hemopexin-heme complex 
D)  Decreased α - β dimers

Question 9

Which of the following is a laboratory test that can be used to identify the occurrence of intravascular hemolysis?

Accepted Answer

A)  Prussian blue stain of renal tubular cells 
B)  Nitric oxide concentration 
C)  Chloride shift 
D)  Isoelectric focusing 
A)  Prussian blue stain of renal tubular cells 
B)  Nitric oxide concentration 
C)  Chloride shift 
D)  Isoelectric focusing

Question 10

Which of the following is detected using the Schumm's Test?

Accepted Answer

A)  Sulfhemoglobin 
B)  Methemoglobin 
C)  Methemalbumin 
D)  Carboxyhemoglobin 
A)  Sulfhemoglobin 
B)  Methemoglobin 
C)  Methemalbumin 
D)  Carboxyhemoglobin

Question 11

The measurement of glycosylated hemoglobin is used as an indicator of what disease process?

Accepted Answer

A)  Anemia 
B)  Oxygen affinity 
C)  Cyanosis 
D)  Diabetes 
A)  Anemia 
B)  Oxygen affinity 
C)  Cyanosis 
D)  Diabetes

Question 12

Which of the following sets of values represents a normal adult hemoglobin distribution?

Accepted Answer

A)  90% A, 5% A2, 5% F 
B)  90% A, 8% A2, 2% F 
C)  97% A, 1% F, 2% A2 
D)  96% A, 2% A2, 4% F 
A)  90% A, 5% A2, 5% F 
B)  90% A, 8% A2, 2% F 
C)  97% A, 1% F, 2% A2 
D)  96% A, 2% A2, 4% F

Question 13

Which of the following causes a left shift in the oxygen dissociation curve (normal blood pH: 7.35-7.45)?

Accepted Answer

A)  A blood pH of 7.54 
B)  A body temperature of 103°F 
C)  An increased 2, 3-BPG concentration 
D)  An increased pCO2 
A)  A blood pH of 7.54 
B)  A body temperature of 103°F 
C)  An increased 2, 3-BPG concentration 
D)  An increased pCO2

Question 14

Which non-alpha-globin chain composes the predominating normal hemoglobin in adults?

Accepted Answer

A)  Gamma 
B)  Delta 
C)  Beta 
D)  Zeta 
A)  Gamma 
B)  Delta 
C)  Beta 
D)  Zeta

Question 15

To regulate the amount of heme produced, what enzyme must be regulated?

Accepted Answer

A)  ALAS 
B)  PBG deaminase 
C)  Uroporphyrinogen III 
D)  Ferrochelatase 
A)  ALAS 
B)  PBG deaminase 
C)  Uroporphyrinogen III 
D)  Ferrochelatase

Question 16

When blood leaves the lungs and reaches the tissues, the PO2 decreases and the P50 level of O2 will:

Accepted Answer

A)  Decrease 
B)  Increase 
C)  Equilibrate to the PCO2 level 
D)  Not change 
A)  Decrease 
B)  Increase 
C)  Equilibrate to the PCO2 level 
D)  Not change

Question 17

How can you detect methemoglobin in the laboratory?

Accepted Answer

A)  By spectral analysis at 541 nm 
B)  By spectral analysis at 630 nm 
C)  By hemoglobin quantitation using acid elution techniques 
D)  By looking at the patient's blood color-it will be blue 
A)  By spectral analysis at 541 nm 
B)  By spectral analysis at 630 nm 
C)  By hemoglobin quantitation using acid elution techniques 
D)  By looking at the patient's blood color-it will be blue

Question 18

How is oxygen transport affected in a patient with a defect in beta globin chain production? A patient with a defect in alpha chain production?

Accepted Answer

Defects in globin chain production will

Question 19

How would a tense configuration of hemoglobin impact the transport of oxygen? Explain your answer.

Accepted Answer

Tense configuration is produce

Question 20

What are normal values for forms of hemoglobin found in an infant under the age of 1 year? Over the age of 1? If they are the same, why? If they are different, why?

Accepted Answer

Under age 1: 90-95% hemoglobin F; up to

Exam 6: Hemoglobin

Which abnormal hemoglobin contains a molecule of carbon monoxide?

What are the chain designations for hemoglobin F?

In the complete hemoglobin structure, iron is:

When mutations occur in the globin chains of hemoglobin, what two interactions can be impaired?

Which of the following is an expression of the oxygen affinity of hemoglobin?

Correlate embryonic/fetal hemoglobin production to stages of fetal hematopoiesis.

Which of the following is not a breakdown product of hemoglobin:

An anemic patient has increased serum bilirubin. Which of the following laboratory test results would indicate intravascular hemolysis in a patient?

Which of the following is a laboratory test that can be used to identify the occurrence of intravascular hemolysis?

Which of the following is detected using the Schumm's Test?

The measurement of glycosylated hemoglobin is used as an indicator of what disease process?

Which of the following sets of values represents a normal adult hemoglobin distribution?

Which of the following causes a left shift in the oxygen dissociation curve (normal blood pH: 7.35-7.45)?

Which non-alpha-globin chain composes the predominating normal hemoglobin in adults?

To regulate the amount of heme produced, what enzyme must be regulated?

When blood leaves the lungs and reaches the tissues, the PO2 decreases and the P50 level of O2 will:

How can you detect methemoglobin in the laboratory?

How is oxygen transport affected in a patient with a defect in beta globin chain production? A patient with a defect in alpha chain production?

How would a tense configuration of hemoglobin impact the transport of oxygen? Explain your answer.

What are normal values for forms of hemoglobin found in an infant under the age of 1 year? Over the age of 1? If they are the same, why? If they are different, why?

Introduction

Cellular Homeostasis

Structure and Function of Hematopoietic Organs

Hematopoiesis

The Erythrocyte

Granulocytes and Monocytes

Lymphocytes

The Platelet

The Complete Blood Count and Peripheral Blood Smear Evaluation

Introduction to Anemia

Anemias of Disordered Iron Metabolism and Heme Synthesis

Hemoglobinopathies: Qualitative Defects

Thalassemia

Megaloblastic and Nonmegaloblastic Macrocytic Anemias

Hypoproliferative Anemias

Hemolytic Anemia: Membrane Defects

Hemolytic Anemia: Enzyme Deficiencies

Hemolytic Anemia: Immune Anemias

Hemolytic Anemia: Nonimmune Defects

Nonmalignant Disorders of Leukocytes: Granulocytes and Monocytes

Nonmalignant Lymphocyte Disorders

Introduction to Hematopoietic Neoplasms

Myeloproliferative Neoplasms

Myelodysplastic Syndromes

Acute Myeloid Leukemias

Precursor Lymphoid Neoplasms

Mature Lymphoid Neoplasms

Hematopoietic Stem Cell Transplantation

Morphologic Analysis of Body Fluids in the Hematology

Primary Hemostasis

Secondary Hemostasis and Fibrinolysis

Disorders of Primary Hemostasis

Disorders of Secondary Hemostasis

Thrombophilia

Hemostasis: Laboratory Testing and Instrumentation

Hematology Procedures

Bone Marrow Examination

Automation in Hematology

Flow Cytometry

Chromosome Analysis of Hematopoietic and Lymphoid Disorders

Molecular Analysis of Hematologic Diseases

Quality Assessment in the Hematology Laboratory

Filters

When blood leaves the lungs and reaches the tissues, the PO₂decreases and the P₅₀level of O₂will: