Question 1

Aggregates that form in the RBC as a result of oxidation, denaturation, and precipitation of globin are called __________.

Accepted Answer

A)  Siderotic granules 
B)  Pappenheimer bodies 
C)  Howell-Jolly bodies 
D)  Heinz bodies 
E)  None of the above 
A)  Siderotic granules 
B)  Pappenheimer bodies 
C)  Howell-Jolly bodies 
D)  Heinz bodies 
E)  None of the above

Question 2

Proteins that extend from the outer surface and traverse the entire RBC membrane to the inner cytoplasmic side are termed __________ membrane proteins.

Accepted Answer

A)  Integral 
B)  Peripheral 
C)  Cytoplasmic 
D)  All of the above 
E)  None of the above 
A)  Integral 
B)  Peripheral 
C)  Cytoplasmic 
D)  All of the above 
E)  None of the above

Question 3

What is the normal level of plasma haptoglobin?

Accepted Answer

A)  50-200 mg/dL 
B)  5 g/L 
C)  2-5 mg/dL 
D)  50-100 mg/dL 
E)  None of the above 
A)  50-200 mg/dL 
B)  5 g/L 
C)  2-5 mg/dL 
D)  50-100 mg/dL 
E)  None of the above

Question 4

Normal adult hemoglobin A consists of:

Accepted Answer

A)  Two alpha chains 
B)  Two beta chains 
C)  Four heme groups 
D)  All of the above 
E)  None of the above 
A)  Two alpha chains 
B)  Two beta chains 
C)  Four heme groups 
D)  All of the above 
E)  None of the above

Question 5

What percentage of the destruction of senescent (old) RBCs occurs by the processing of extravascular hemolysis?

Accepted Answer

A)  90% 
B)  50% 
C)  5-10% 
D)  25% 
E)  None of the above 
A)  90% 
B)  50% 
C)  5-10% 
D)  25% 
E)  None of the above

Question 6

Which of the following abnormal RBC morphologies is associated with abetalipoproteinemia?

Accepted Answer

A)  Schistocytes 
B)  Target cells 
C)  Spherocytes 
D)  Acanthocytes 
E)  None of the above 
A)  Schistocytes 
B)  Target cells 
C)  Spherocytes 
D)  Acanthocytes 
E)  None of the above

Question 7

Which of the following types of hemoglobin is (are) found in adult RBCs?

Accepted Answer

A)  95-97% HbA 
B)  2-3% HbA2 
C)  2% or less HbF 
D)  All of the above 
E)  None of the above 
A)  95-97% HbA 
B)  2-3% HbA2 
C)  2% or less HbF 
D)  All of the above 
E)  None of the above

Question 8

At what level of increased circulating carboxyhemoglobin may cyanosis, anemia, and death occur due to a tissue oxygen deficit related to the increased concentration of this abnormal hemoglobin?

Accepted Answer

A)  5.0 g/dL 
B)  1.5 g/dL 
C)  0.5 g/dL 
D)  0.1 g/dL 
A)  5.0 g/dL 
B)  1.5 g/dL 
C)  0.5 g/dL 
D)  0.1 g/dL

Question 9

In hemoglobinuria, methemoglobin predominates in acidic urine and gives it what color?

Accepted Answer

A)  Purple 
B)  Red 
C)  Brown 
D)  None of the above 
E)  All of the above 
A)  Purple 
B)  Red 
C)  Brown 
D)  None of the above 
E)  All of the above

Question 10

The storage form of iron is termed:

Accepted Answer

A)  Haptoglobin 
B)  Ferritin 
C)  Transferrin 
D)  Hemopexin 
E)  None of the above 
A)  Haptoglobin 
B)  Ferritin 
C)  Transferrin 
D)  Hemopexin 
E)  None of the above

Question 11

Decreased cellular deformability leads to:

Accepted Answer

A)  Increased RBC survival 
B)  No change in RBC survival 
C)  Decreased RBC survival 
D)  Normal RBC survival 
E)  None of the above 
A)  Increased RBC survival 
B)  No change in RBC survival 
C)  Decreased RBC survival 
D)  Normal RBC survival 
E)  None of the above

Question 12

Which of the following is the RBC intracellular-to-extracellular ratio for sodium?

Accepted Answer

A)  25:1 
B)  1:12 
C)  12:1 
D)  1:25 
E)  None of the above 
A)  25:1 
B)  1:12 
C)  12:1 
D)  1:25 
E)  None of the above

Question 13

Normal hemoglobin production is dependent upon which of the following processes?

Accepted Answer

A)  Adequate globin synthesis 
B)  Adequate iron delivery and supply 
C)  Adequate synthesis of protoporphyrins 
D)  All of the above 
E)  None of the above 
A)  Adequate globin synthesis 
B)  Adequate iron delivery and supply 
C)  Adequate synthesis of protoporphyrins 
D)  All of the above 
E)  None of the above

Question 14

The RBC membrane is relatively impermeable to which of the following?

Accepted Answer

A)  Na+ 
B)  K+ 
C)  Ca2+ 
D)  All of the above 
E)  None of the above 
A)  Na+ 
B)  K+ 
C)  Ca2+ 
D)  All of the above 
E)  None of the above

Question 15

A shift to the right of the hemoglobin oxygen dissociation curve can occur as a result of _____________________.

Accepted Answer

A)  Hypoxia 
B)  Alkalosis 
C)  Increase quantity of methemoglobin 
D)  Increase quantity of hemoglobin F 
E)  None of the above 
A)  Hypoxia 
B)  Alkalosis 
C)  Increase quantity of methemoglobin 
D)  Increase quantity of hemoglobin F 
E)  None of the above

Question 16

Which of the following RBC metabolic pathways produces the pyridine nucleotide NADPH from NADP+ along with reduced glutathione to provide the main line of defense against oxidative injury?

Accepted Answer

A)  Embden-Meyerhof 
B)  Hexose monophosphate (phosphogluconate) 
C)  Methemoglobin reductase 
D)  Luebering-Rapaport 
E)  None of the above 
A)  Embden-Meyerhof 
B)  Hexose monophosphate (phosphogluconate) 
C)  Methemoglobin reductase 
D)  Luebering-Rapaport 
E)  None of the above

Question 17

Two thirds of the total body iron is bound to __________ in the hemoglobin molecule.

Accepted Answer

A)  Globin 
B)  Transferrin 
C)  Heme 
D)  Hemopexin 
E)  None of the above 
A)  Globin 
B)  Transferrin 
C)  Heme 
D)  Hemopexin 
E)  None of the above

Question 18

What percentage of ATP needed by the RBC is generated by the Embden-Meyerhof glycolytic pathway?

Accepted Answer

A)  10% 
B)  50% 
C)  5% 
D)  90% 
E)  None of the above 
A)  10% 
B)  50% 
C)  5% 
D)  90% 
E)  None of the above

Question 19

What is the normal lifespan of the RBC in circulation?

Accepted Answer

A)  60 days 
B)  12 days 
C)  120 days 
D)  80 days 
E)  None of the above 
A)  60 days 
B)  12 days 
C)  120 days 
D)  80 days 
E)  None of the above

Question 20

Which of the following RBC metabolic pathways is important in maintaining the heme iron in the reduced (Fe2+, ferrous) functional state?

Accepted Answer

A)  Embden-Meyerhof 
B)  Hexose monophosphate (phosphogluconate) 
C)  Methemoglobin reductase 
D)  Luebering-Rapaport 
E)  None of the above 
A)  Embden-Meyerhof 
B)  Hexose monophosphate (phosphogluconate) 
C)  Methemoglobin reductase 
D)  Luebering-Rapaport 
E)  None of the above

Exam 3: The Red Blood Cell: Structure and Function

Aggregates that form in the RBC as a result of oxidation, denaturation, and precipitation of globin are called __________.

Proteins that extend from the outer surface and traverse the entire RBC membrane to the inner cytoplasmic side are termed __________ membrane proteins.

What is the normal level of plasma haptoglobin?

Normal adult hemoglobin A consists of:

What percentage of the destruction of senescent (old) RBCs occurs by the processing of extravascular hemolysis?

Which of the following abnormal RBC morphologies is associated with abetalipoproteinemia?

Which of the following types of hemoglobin is (are) found in adult RBCs?

At what level of increased circulating carboxyhemoglobin may cyanosis, anemia, and death occur due to a tissue oxygen deficit related to the increased concentration of this abnormal hemoglobin?

In hemoglobinuria, methemoglobin predominates in acidic urine and gives it what color?

The storage form of iron is termed:

Decreased cellular deformability leads to:

Which of the following is the RBC intracellular-to-extracellular ratio for sodium?

Normal hemoglobin production is dependent upon which of the following processes?

The RBC membrane is relatively impermeable to which of the following?

A shift to the right of the hemoglobin oxygen dissociation curve can occur as a result of _____________________.

Which of the following RBC metabolic pathways produces the pyridine nucleotide NADPH from NADP+ along with reduced glutathione to provide the main line of defense against oxidative injury?

Two thirds of the total body iron is bound to __________ in the hemoglobin molecule.

What percentage of ATP needed by the RBC is generated by the Embden-Meyerhof glycolytic pathway?

What is the normal lifespan of the RBC in circulation?

Which of the following RBC metabolic pathways is important in maintaining the heme iron in the reduced (Fe2+, ferrous) functional state?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Which of the following RBC metabolic pathways produces the pyridine nucleotide NADPH from NADP⁺ along with reduced glutathione to provide the main line of defense against oxidative injury?

Which of the following RBC metabolic pathways is important in maintaining the heme iron in the reduced (Fe²⁺, ferrous) functional state?