Question 1

An autohemolysin can be defined as:

Accepted Answer

A)  A warm autoantibody that binds a patient's red cells at low temperatures and fixes complement 
B)  A cold autoantibody that binds a patient's red cells at low temperatures and fixes complement 
C)  A cold autoantibody that binds a patient's red cells at warm temperatures and fixes complement 
D)  A cold autoantibody that binds a patient's red cells at low temperatures but does not fix complement 
E)  All of the above 
A)  A warm autoantibody that binds a patient's red cells at low temperatures and fixes complement 
B)  A cold autoantibody that binds a patient's red cells at low temperatures and fixes complement 
C)  A cold autoantibody that binds a patient's red cells at warm temperatures and fixes complement 
D)  A cold autoantibody that binds a patient's red cells at low temperatures but does not fix complement 
E)  All of the above B

Question 2

On a peripheral blood smear of a newborn suspected of HDN, one morphological abnormality that would help distinguish ABO HDN from Rh HDN is:

Accepted Answer

A)  Reticulocytosis 
B)  Leukocytosis 
C)  Spherocytes 
D)  Nucleated red cells 
E)  Target cells 
A)  Reticulocytosis 
B)  Leukocytosis 
C)  Spherocytes 
D)  Nucleated red cells 
E)  Target cells D

Question 3

An immune hemolytic disorder in which red cells of the fetus and newborn are destroyed by maternal IgG antibody is:

Accepted Answer

A)  Warm autoimmune hemolytic anemia 
B)  Hemolytic disease of the newborn (HDN) 
C)  Hydrops fetalis 
D)  Hereditary persistence of fetal hemoglobin 
E)  Cold autoimmune hemolytic anemia 
A)  Warm autoimmune hemolytic anemia 
B)  Hemolytic disease of the newborn (HDN) 
C)  Hydrops fetalis 
D)  Hereditary persistence of fetal hemoglobin 
E)  Cold autoimmune hemolytic anemia B

Question 4

Where does extravascular phagocytosis of red cells occur?

Accepted Answer

A)  Spleen and liver 
B)  Liver and lymph nodes 
C)  Kidney and liver 
D)  Lungs and liver 
E)  Bone marrow and lymph nodes 
A)  Spleen and liver 
B)  Liver and lymph nodes 
C)  Kidney and liver 
D)  Lungs and liver 
E)  Bone marrow and lymph nodes

Question 5

Which drug mechanism functions by modifying the red cell membrane so that normal plasma proteins are absorbed non-immunologically?

Accepted Answer

A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune 
A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune

Question 6

The presence of these cells in the peripheral blood suggests that the patient is in the hemolytic phase of bartonellosis:

Accepted Answer

A)  Spherocytes 
B)  Nucleated red cells 
C)  Acanthocytes 
D)  Schistocytes 
E)  Target cells 
A)  Spherocytes 
B)  Nucleated red cells 
C)  Acanthocytes 
D)  Schistocytes 
E)  Target cells

Question 7

What cold autoantibodies are found in the serum of normal, healthy individuals?

Accepted Answer

A)  Anti-H 
B)  Anti-I 
C)  Anti-IH 
D)  All of the above 
E)  None of the above 
A)  Anti-H 
B)  Anti-I 
C)  Anti-IH 
D)  All of the above 
E)  None of the above

Question 8

A blood transfusion for a patient with cold agglutinin syndrome will require:

Accepted Answer

A)  Irradiation 
B)  Transfusion with a warming coil 
C)  HbS negative 
D)  CMV negative 
E)  Washing of red cells 
A)  Irradiation 
B)  Transfusion with a warming coil 
C)  HbS negative 
D)  CMV negative 
E)  Washing of red cells

Question 9

Which IgG subclass cannot activate complement in immune hemolysis?

Accepted Answer

A)  IgG1 
B)  IgG2 
C)  IgG3 
D)  IgG4 
E)  IgG1 and IgG2 
A)  IgG1 
B)  IgG2 
C)  IgG3 
D)  IgG4 
E)  IgG1 and IgG2

Question 10

Which type of HDN is the most frequent?

Accepted Answer

A)  Rh HDN 
B)  Duffy HDN 
C)  ABO HDN 
D)  Kidd HDN 
E)  Kell HDN 
A)  Rh HDN 
B)  Duffy HDN 
C)  ABO HDN 
D)  Kidd HDN 
E)  Kell HDN

Question 11

What pathological cold antibody disease is found in children in association with infectious mononucleosis, mumps, measles, and chicken pox?

Accepted Answer

A)  Paroxysmal cold hemoglobinuria 
B)  Mycoplasma pneumoniae associated disease 
C)  Cold agglutinin syndrome 
D)  Secondary cold AIHA 
E)  Paroxysmal nocturnal hemoglobinuria 
A)  Paroxysmal cold hemoglobinuria 
B)  Mycoplasma pneumoniae associated disease 
C)  Cold agglutinin syndrome 
D)  Secondary cold AIHA 
E)  Paroxysmal nocturnal hemoglobinuria

Question 12

Alloimmune hemolytic anemia may result from:

Accepted Answer

A)  Pregnancy 
B)  Blood transfusion 
C)  Organ transplant 
D)  All of the above 
E)  None of the above 
A)  Pregnancy 
B)  Blood transfusion 
C)  Organ transplant 
D)  All of the above 
E)  None of the above

Question 13

The mechanism of direct lysis resulting from the release of lytic enzymes from effector cells that act on the red cell membrane is referred to as:

Accepted Answer

A)  Antigen-dependent cellular cytotoxicity 
B)  Antibody-independent cellular cytotoxicity 
C)  Antibody-dependent cellular cytotoxicity 
D)  Antigen-independent cellular cytotoxicity 
E)  None of the above 
A)  Antigen-dependent cellular cytotoxicity 
B)  Antibody-independent cellular cytotoxicity 
C)  Antibody-dependent cellular cytotoxicity 
D)  Antigen-independent cellular cytotoxicity 
E)  None of the above

Question 14

Drug-induced immune hemolytic anemia represents ____ of autoimmune hemolytic anemias.

Accepted Answer

A)  16% 
B)  12% 
C)  70% 
D)  2% 
E)  40% 
A)  16% 
B)  12% 
C)  70% 
D)  2% 
E)  40%

Question 15

The main site of destruction for cells coated with complement alone is the __________.

Accepted Answer

A)  Liver 
B)  Spleen 
C)  Kidney 
D)  Marrow 
E)  None of the above 
A)  Liver 
B)  Spleen 
C)  Kidney 
D)  Marrow 
E)  None of the above

Question 16

In HDN, when extramedullary hematopoiesis takes over for the fetal bone marrow to compensate for increased red cell destruction, this results in:

Accepted Answer

A)  A hypocellular bone marrow 
B)  Hepatosplenomegaly 
C)  Decrease in bilirubin 
D)  Aplastic anemia 
E)  Spherocytosis 
A)  A hypocellular bone marrow 
B)  Hepatosplenomegaly 
C)  Decrease in bilirubin 
D)  Aplastic anemia 
E)  Spherocytosis

Question 17

What pathological cold antibody disease occurs in persons older than 50 years of age and demonstrates acrocyanosis of the hands and feet and the presence of a lymphoproliferative disorder?

Accepted Answer

A)  Paroxysmal cold hemoglobinuria 
B)  Mycoplasma pneumoniae associated disease 
C)  Cold agglutinin syndrome 
D)  Secondary cold AIHA 
E)  Paroxysmal nocturnal hemoglobinuria 
A)  Paroxysmal cold hemoglobinuria 
B)  Mycoplasma pneumoniae associated disease 
C)  Cold agglutinin syndrome 
D)  Secondary cold AIHA 
E)  Paroxysmal nocturnal hemoglobinuria

Question 18

A patient who has been taking quinidine presents with hemoglobinemia and hemoglobinuria. His DAT shows specificity with anti-complement reagents but not with anti-IgG. His eluate is nonreactive. Which drug mechanism is responsible?

Accepted Answer

A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune 
A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune

Question 19

Which drug is primarily associated with the drug absorption (hapten) mechanism?

Accepted Answer

A)  Aldomet 
B)  Streptomycins 
C)  Penicillin 
D)  Acetaminophen 
E)  Primaquine 
A)  Aldomet 
B)  Streptomycins 
C)  Penicillin 
D)  Acetaminophen 
E)  Primaquine

Question 20

The alternate pathway may be triggered by:

Accepted Answer

A)  Microorganisms 
B)  Polysaccharides 
C)  Lipopolysaccharides 
D)  All of the above 
E)  None of the above 
A)  Microorganisms 
B)  Polysaccharides 
C)  Lipopolysaccharides 
D)  All of the above 
E)  None of the above

Exam 13: Hemolytic Anemias: Extracorpuscular Defects

An autohemolysin can be defined as:

On a peripheral blood smear of a newborn suspected of HDN, one morphological abnormality that would help distinguish ABO HDN from Rh HDN is:

An immune hemolytic disorder in which red cells of the fetus and newborn are destroyed by maternal IgG antibody is:

Where does extravascular phagocytosis of red cells occur?

Which drug mechanism functions by modifying the red cell membrane so that normal plasma proteins are absorbed non-immunologically?

The presence of these cells in the peripheral blood suggests that the patient is in the hemolytic phase of bartonellosis:

What cold autoantibodies are found in the serum of normal, healthy individuals?

A blood transfusion for a patient with cold agglutinin syndrome will require:

Which IgG subclass cannot activate complement in immune hemolysis?

Which type of HDN is the most frequent?

What pathological cold antibody disease is found in children in association with infectious mononucleosis, mumps, measles, and chicken pox?

Alloimmune hemolytic anemia may result from:

The mechanism of direct lysis resulting from the release of lytic enzymes from effector cells that act on the red cell membrane is referred to as:

Drug-induced immune hemolytic anemia represents ____ of autoimmune hemolytic anemias.

The main site of destruction for cells coated with complement alone is the __________.

In HDN, when extramedullary hematopoiesis takes over for the fetal bone marrow to compensate for increased red cell destruction, this results in:

What pathological cold antibody disease occurs in persons older than 50 years of age and demonstrates acrocyanosis of the hands and feet and the presence of a lymphoproliferative disorder?

A patient who has been taking quinidine presents with hemoglobinemia and hemoglobinuria. His DAT shows specificity with anti-complement reagents but not with anti-IgG. His eluate is nonreactive. Which drug mechanism is responsible?

Which drug is primarily associated with the drug absorption (hapten) mechanism?

The alternate pathway may be triggered by:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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