Question 1

The final diagnosis of any lymphoproliferative disorder encompasses clinical data obtained from __________ analysis.

Accepted Answer

A)  Morphologic 
B)  Histologic 
C)  Immunologic 
D)  All of the above 
E)  None of the above 
A)  Morphologic 
B)  Histologic 
C)  Immunologic 
D)  All of the above 
E)  None of the above D

Question 2

What definitive factor differentiates prolymphocytic leukemia (PL) from CLL?

Accepted Answer

A)  Extreme leukocytosis (>100 F1F1F1S1F1F1F10 10/L) 
B)  Splenomegaly without lymphadenopathy 
C)  Presence of prolymphocytes 
D)  A and B 
E)  B and C 
A)  Extreme leukocytosis (>100 F1F1F1S1F1F1F10 10/L) 
B)  Splenomegaly without lymphadenopathy 
C)  Presence of prolymphocytes 
D)  A and B 
E)  B and C D

Question 3

In CLL there is a malignant proliferation of which cell?

Accepted Answer

A)  B lymphocytes 
B)  T lymphocytes 
C)  Natural killer (NK) lymphocytes 
D)  Null lymphocytes 
E)  None of the above 
A)  B lymphocytes 
B)  T lymphocytes 
C)  Natural killer (NK) lymphocytes 
D)  Null lymphocytes 
E)  None of the above A

Question 4

What age group does CLL primarily affect?

Accepted Answer

A)  4-20 years 
B)  20-40 years 
C)  >50 years 
D)  1-5 years 
E)  None of the above 
A)  4-20 years 
B)  20-40 years 
C)  >50 years 
D)  1-5 years 
E)  None of the above

Question 5

Clinical features of CLL include all of the following except:

Accepted Answer

A)  Absolute lymphocytosis 
B)  Splenomegaly 
C)  Axial lymphadenopathy 
D)  Thrombocytosis 
E)  None of the above 
A)  Absolute lymphocytosis 
B)  Splenomegaly 
C)  Axial lymphadenopathy 
D)  Thrombocytosis 
E)  None of the above

Question 6

Autoimmune hemolytic anemia in CLL is characterized by the following:

Accepted Answer

A)  A positive direct Coombs' test 
B)  An increased indirect serum bilirubin 
C)  Reticulocytosis 
D)  All of the above 
E)  None of the above 
A)  A positive direct Coombs' test 
B)  An increased indirect serum bilirubin 
C)  Reticulocytosis 
D)  All of the above 
E)  None of the above

Question 7

What is characteristic morphology for Sézary cells?

Accepted Answer

A)  Dark-staining hyperchromatic nuclear chromatin with numerous folds 
B)  Light-staining hyperchromatic nuclear chromatin with numerous folds 
C)  Dark-staining hypochromatic nuclear chromatin with many clumps 
D)  Light-staining hypochromatic nuclear chromatin with numerous grooves 
E)  None of the above 
A)  Dark-staining hyperchromatic nuclear chromatin with numerous folds 
B)  Light-staining hyperchromatic nuclear chromatin with numerous folds 
C)  Dark-staining hypochromatic nuclear chromatin with many clumps 
D)  Light-staining hypochromatic nuclear chromatin with numerous grooves 
E)  None of the above

Question 8

What is the classification of anemia in CLL?

Accepted Answer

A)  Macrocytic/hyperchromic 
B)  Normocytic/normochromic 
C)  Microcytic/hypochromic 
D)  Microcytic/normochromic 
E)  None of the above 
A)  Macrocytic/hyperchromic 
B)  Normocytic/normochromic 
C)  Microcytic/hypochromic 
D)  Microcytic/normochromic 
E)  None of the above

Question 9

What are the consequences of the accumulation of the lymphocytes in the peripheral blood and bone marrow in a patient with CLL?

Accepted Answer

A)  Neutropenia 
B)  Anemia 
C)  Thrombocytopenia 
D)  All of the above 
E)  None of the above 
A)  Neutropenia 
B)  Anemia 
C)  Thrombocytopenia 
D)  All of the above 
E)  None of the above

Question 10

CLL has been known to occur simultaneously with what hematologic disorder?

Accepted Answer

A)  Acute myeloblastic leukemia (AML) 
B)  Acute lymphocytic leukemia (ALL) 
C)  Non-Hodgkin's lymphoma 
D)  Hairy cell leukemia 
E)  None of the above 
A)  Acute myeloblastic leukemia (AML) 
B)  Acute lymphocytic leukemia (ALL) 
C)  Non-Hodgkin's lymphoma 
D)  Hairy cell leukemia 
E)  None of the above

Question 11

Atypical lymphocytes in reactive lymphocytosis are a proliferation of which type of cell?

Accepted Answer

A)  T cell 
B)  B cell 
C)  NK cell 
D)  Null cell 
E)  None of the above 
A)  T cell 
B)  B cell 
C)  NK cell 
D)  Null cell 
E)  None of the above

Question 12

Immune dysfunction within proliferating B cells of CLL is indicated by:

Accepted Answer

A)  Monoclonal gammopathy 
B)  Hypogammaglobulinemia 
C)  Hypergammaglobulinemia 
D)  All of the above 
E)  None of the above 
A)  Monoclonal gammopathy 
B)  Hypogammaglobulinemia 
C)  Hypergammaglobulinemia 
D)  All of the above 
E)  None of the above

Question 13

Which immunologic technique is helpful in detecting very small numbers of malignant cells or amplifying gene rearrangements in malignant clones?

Accepted Answer

A)  Monoclonal antibodies 
B)  Polyclonal antibodies 
C)  PCR technology 
D)  DNA probe 
E)  None of the above 
A)  Monoclonal antibodies 
B)  Polyclonal antibodies 
C)  PCR technology 
D)  DNA probe 
E)  None of the above

Question 14

The following is true regarding hairy cell leukemia:

Accepted Answer

A)  Pancytopenia is a common finding 
B)  Lymphocytes appear as hair-like cytoplasmic projections 
C)  Alkaline phosphatase is not inhibited by tartrate-resistant acid phosphatase (TRAP) reaction 
D)  A and B 
E)  A, B, and C 
A)  Pancytopenia is a common finding 
B)  Lymphocytes appear as hair-like cytoplasmic projections 
C)  Alkaline phosphatase is not inhibited by tartrate-resistant acid phosphatase (TRAP) reaction 
D)  A and B 
E)  A, B, and C

Question 15

The demonstration of SIg (surface immunoglobulin) is the classic marker for __________.

Accepted Answer

A)  T cells 
B)  B cells 
C)  Null cells 
D)  NK cells 
E)  None of the above 
A)  T cells 
B)  B cells 
C)  Null cells 
D)  NK cells 
E)  None of the above

Question 16

What is meant by monoclonality?

Accepted Answer

A)  Presence of kappa and lambda chains 
B)  Presence of either kappa or lambda light chains 
C)  Absence of kappa and lambda light chains 
D)  Presence of epsilon chain 
E)  None of the above 
A)  Presence of kappa and lambda chains 
B)  Presence of either kappa or lambda light chains 
C)  Absence of kappa and lambda light chains 
D)  Presence of epsilon chain 
E)  None of the above

Question 17

Well-differentiated lymphocytic leukemia is a diffuse non-Hodgkin's lymphoma that is characterized by neoplastic transformation of __________.

Accepted Answer

A)  T lymphocytes 
B)  B lymphocytes 
C)  NK cells 
D)  Null cells 
E)  None of the above 
A)  T lymphocytes 
B)  B lymphocytes 
C)  NK cells 
D)  Null cells 
E)  None of the above

Question 18

The most common etiologic agent for reactive lymphocytosis is:

Accepted Answer

A)  Viral 
B)  Bacterial 
C)  Fungal 
D)  Unknown 
E)  None of the above 
A)  Viral 
B)  Bacterial 
C)  Fungal 
D)  Unknown 
E)  None of the above

Question 19

The most common chromosomal abnormality in B-CLL (B lymphocytes) is an extra chromosome called __________.

Accepted Answer

A)  Inversion 12 
B)  Trisomy 12 
C)  Trisomy 7 
D)  Inversion 7 
E)  None of the above 
A)  Inversion 12 
B)  Trisomy 12 
C)  Trisomy 7 
D)  Inversion 7 
E)  None of the above

Question 20

Which morphologic factors distinguish the lymphocytes of CLL from normal mature lymphocytes?

Accepted Answer

A)  Nucleoli 
B)  N/C ratio 
C)  Exaggerated nuclear chromatin 
D)  Secondary granules 
E)  None of the above 
A)  Nucleoli 
B)  N/C ratio 
C)  Exaggerated nuclear chromatin 
D)  Secondary granules 
E)  None of the above

Exam 20: Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The final diagnosis of any lymphoproliferative disorder encompasses clinical data obtained from __________ analysis.

What definitive factor differentiates prolymphocytic leukemia (PL) from CLL?

In CLL there is a malignant proliferation of which cell?

What age group does CLL primarily affect?

Clinical features of CLL include all of the following except:

Autoimmune hemolytic anemia in CLL is characterized by the following:

What is characteristic morphology for Sézary cells?

What is the classification of anemia in CLL?

What are the consequences of the accumulation of the lymphocytes in the peripheral blood and bone marrow in a patient with CLL?

CLL has been known to occur simultaneously with what hematologic disorder?

Atypical lymphocytes in reactive lymphocytosis are a proliferation of which type of cell?

Immune dysfunction within proliferating B cells of CLL is indicated by:

Which immunologic technique is helpful in detecting very small numbers of malignant cells or amplifying gene rearrangements in malignant clones?

The following is true regarding hairy cell leukemia:

The demonstration of SIg (surface immunoglobulin) is the classic marker for __________.

What is meant by monoclonality?

Well-differentiated lymphocytic leukemia is a diffuse non-Hodgkin's lymphoma that is characterized by neoplastic transformation of __________.

The most common etiologic agent for reactive lymphocytosis is:

The most common chromosomal abnormality in B-CLL (B lymphocytes) is an extra chromosome called __________.

Which morphologic factors distinguish the lymphocytes of CLL from normal mature lymphocytes?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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