Question 1

Diagnosis of CLL can be confirmed immunologically by the use of monoclonal antibodies that detect __________ antigens.

Accepted Answer

A)  Cluster differentiation (C
D)  
B)  Chromosome designation 
C)  Cytoplasmic differentiation 
D)  Leukocyte differentiation 
E)  None of the above 
A)  Cluster differentiation (C
D)  
B)  Chromosome designation 
C)  Cytoplasmic differentiation 
D)  Leukocyte differentiation 
E)  None of the above

Question 2

The leukemia phase of cutaneous T-cell lymphoma, mycosis fungoides, is called __________.

Accepted Answer

A)  Hunter's syndrome 
B)  Hairy cell leukemia 
C)  Sézary syndrome 
D)  Idiopathic myelofibrosis 
E)  None of the above 
A)  Hunter's syndrome 
B)  Hairy cell leukemia 
C)  Sézary syndrome 
D)  Idiopathic myelofibrosis 
E)  None of the above

Question 3

Required hematologic findings for a diagnosis of CLL include:

Accepted Answer

A)  5000/µL lymphocytes in the peripheral blood 
B)  30% lymphocytosis in bone marrow 
C)  Normocytic/hypochromic anemia 
D)  A and B 
E)  A and C 
A)  5000/µL lymphocytes in the peripheral blood 
B)  30% lymphocytosis in bone marrow 
C)  Normocytic/hypochromic anemia 
D)  A and B 
E)  A and C

Question 4

Suppression of all classes of immunoglobulin is evident in CLL, resulting in:

Accepted Answer

A)  Hypergammaglobulinemia 
B)  Decreased susceptibility to infections 
C)  Autoimmune disease 
D)  Hypothyroidism 
E)  None of the above 
A)  Hypergammaglobulinemia 
B)  Decreased susceptibility to infections 
C)  Autoimmune disease 
D)  Hypothyroidism 
E)  None of the above

Question 5

A cell that could suggest that lymphocytes in CLL are not normal is a:

Accepted Answer

A)  Smudge cell 
B)  Lymphoblast 
C)  Monoblast 
D)  All of the above 
E)  None of the above 
A)  Smudge cell 
B)  Lymphoblast 
C)  Monoblast 
D)  All of the above 
E)  None of the above

Question 6

Which may be used to differentiate CLL from ALL?

Accepted Answer

A)  Age of patient 
B)  Nuclear chromatin pattern 
C)  Presence of nucleoli 
D)  All of the above 
E)  None of the above 
A)  Age of patient 
B)  Nuclear chromatin pattern 
C)  Presence of nucleoli 
D)  All of the above 
E)  None of the above

Question 7

All of the following are features of CLL except:

Accepted Answer

A)  Monoclonality 
B)  Polyclonality 
C)  Hypogammaglobulinemia 
D)  Autoimmune disease 
E)  None of the above 
A)  Monoclonality 
B)  Polyclonality 
C)  Hypogammaglobulinemia 
D)  Autoimmune disease 
E)  None of the above

Question 8

In CLL, all of the following might result from the autoimmune phenomenon except:

Accepted Answer

A)  Thalassemia 
B)  Autoimmune hemolytic anemia 
C)  Idiopathic thrombocytopenic purpura (ITP) 
D)  Immune neutropenia 
E)  None of the above 
A)  Thalassemia 
B)  Autoimmune hemolytic anemia 
C)  Idiopathic thrombocytopenic purpura (ITP) 
D)  Immune neutropenia 
E)  None of the above

Question 9

The laboratory test for detecting minimal residual disease in patients who have previously been treated for CLL but currently lack histopathologic evidence of relapse is the:

Accepted Answer

A)  Polymerase chain reaction (PCR) 
B)  Complete blood count (CB
C)  and differential 
C)  Electrophoresis 
D)  All of the above 
E)  None of the above 
A)  Polymerase chain reaction (PCR) 
B)  Complete blood count (CB
C)  and differential 
C)  Electrophoresis 
D)  All of the above 
E)  None of the above

Exam 20: Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

Diagnosis of CLL can be confirmed immunologically by the use of monoclonal antibodies that detect __________ antigens.

The leukemia phase of cutaneous T-cell lymphoma, mycosis fungoides, is called __________.

Required hematologic findings for a diagnosis of CLL include:

Suppression of all classes of immunoglobulin is evident in CLL, resulting in:

A cell that could suggest that lymphocytes in CLL are not normal is a:

Which may be used to differentiate CLL from ALL?

All of the following are features of CLL except:

In CLL, all of the following might result from the autoimmune phenomenon except:

The laboratory test for detecting minimal residual disease in patients who have previously been treated for CLL but currently lack histopathologic evidence of relapse is the:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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