Question 1

The major portion of factor VIII is considered to be a carrier protein called __________.

Accepted Answer

A)  Hageman factor 
B)  von Willebrand factor 
C)  Stuart-Prower factor 
D)  Christmas factor 
E)  Kinin factor 
A)  Hageman factor 
B)  von Willebrand factor 
C)  Stuart-Prower factor 
D)  Christmas factor 
E)  Kinin factor B

Question 2

What result will occur in the coagulation cascade if there is a deficiency of any one of the coagulation factors?

Accepted Answer

A)  Coagulation will not proceed at the normal rate. 
B)  Initiation of the next subsequent reaction is delayed. 
C)  The time required for the clot to form is prolonged. 
D)  Bleeding from the injured vessel continues for a longer time. 
E)  All of the above 
A)  Coagulation will not proceed at the normal rate. 
B)  Initiation of the next subsequent reaction is delayed. 
C)  The time required for the clot to form is prolonged. 
D)  Bleeding from the injured vessel continues for a longer time. 
E)  All of the above E

Question 3

__________ functions as a potent vasodilator and inhibitor of the platelet response.

Accepted Answer

A)  Prostacyclin (PGI2) 
B)  Protein C 
C)  ADPase 
D)  Vitamin D 
E)  None of the above 
A)  Prostacyclin (PGI2) 
B)  Protein C 
C)  ADPase 
D)  Vitamin D 
E)  None of the above A

Question 4

Late FDPs consist of:

Accepted Answer

A)  D and E fragments 
B)  D and Y fragments 
C)  X monomer and Y fragments 
D)  X monomer and D fragments 
E)  Y and E fragments 
A)  D and E fragments 
B)  D and Y fragments 
C)  X monomer and Y fragments 
D)  X monomer and D fragments 
E)  Y and E fragments

Question 5

What is the substrate of the coagulation system?

Accepted Answer

A)  Prothrombin 
B)  Fibrinogen 
C)  Antihemophilic factor 
D)  Calcium 
E)  All of the above 
A)  Prothrombin 
B)  Fibrinogen 
C)  Antihemophilic factor 
D)  Calcium 
E)  All of the above

Question 6

Platelets do not aggregate in Glanzmann's thrombasthenia when:

Accepted Answer

A)  Platelets lack Ib and IIIb 
B)  Calcium deficiency 
C)  Platelets express GPIIb and GPIIIa 
D)  Platelets lack GPIIb and GPIIIa 
E)  None of the above 
A)  Platelets lack Ib and IIIb 
B)  Calcium deficiency 
C)  Platelets express GPIIb and GPIIIa 
D)  Platelets lack GPIIb and GPIIIa 
E)  None of the above

Question 7

Bradykinins function to:

Accepted Answer

A)  Increase vascular permeability 
B)  Contract smooth muscle 
C)  Dilate small blood vessels 
D)  Induce inflammation and pain 
E)  All of the above 
A)  Increase vascular permeability 
B)  Contract smooth muscle 
C)  Dilate small blood vessels 
D)  Induce inflammation and pain 
E)  All of the above

Question 8

What is the correct sequence of events in hemostatic plug formation?

Accepted Answer

A)  Aggregation, adhesion, plug formation, consolidation, fibrin stabilization 
B)  Consolidation, aggregation, adhesion, fibrin stabilization, plug formation 
C)  Adhesion, aggregation, consolidation, plug formation, fibrin stabilization 
D)  Adhesion, aggregation, plug formation, consolidation, fibrin stabilization 
E)  None of the above 
A)  Aggregation, adhesion, plug formation, consolidation, fibrin stabilization 
B)  Consolidation, aggregation, adhesion, fibrin stabilization, plug formation 
C)  Adhesion, aggregation, consolidation, plug formation, fibrin stabilization 
D)  Adhesion, aggregation, plug formation, consolidation, fibrin stabilization 
E)  None of the above

Question 9

Adhesion of platelets to subendothelial fibers is dependent on a plasma protein called __________.

Accepted Answer

A)  Hageman factor 
B)  Stuart-Prower factor 
C)  Christmas factor 
D)  von Willebrand factor 
E)  tissue factor 
A)  Hageman factor 
B)  Stuart-Prower factor 
C)  Christmas factor 
D)  von Willebrand factor 
E)  tissue factor

Question 10

Characteristics of the contact group of coagulation proteins include:

Accepted Answer

A)  Function in the initial phase of the intrinsic activation of coagulation 
B)  Factors are not consumed during coagulation 
C)  Factors are not absorbed by barium sulfate (BaSO4) 
D)  Factors are not vitamin K dependent 
E)  All of the above 
A)  Function in the initial phase of the intrinsic activation of coagulation 
B)  Factors are not consumed during coagulation 
C)  Factors are not absorbed by barium sulfate (BaSO4) 
D)  Factors are not vitamin K dependent 
E)  All of the above

Question 11

Blood coagulation leading to fibrin formation is separated into the __________ and __________ pathways.

Accepted Answer

A)  Intracorpuscular/extracorpuscular 
B)  Intramedullary/extramedullary 
C)  Intravascular/extravascular 
D)  Extrinsic/intrinsic 
E)  None of the above 
A)  Intracorpuscular/extracorpuscular 
B)  Intramedullary/extramedullary 
C)  Intravascular/extravascular 
D)  Extrinsic/intrinsic 
E)  None of the above

Question 12

In the peripheral blood, approximately __________ percent of the platelets are sequestered in the spleen as functional reserves.

Accepted Answer

A)  10% 
B)  20% 
C)  30% 
D)  40% 
E)  None of the above 
A)  10% 
B)  20% 
C)  30% 
D)  40% 
E)  None of the above

Question 13

All of the following coagulation proteins make up the fibrinogen group except:

Accepted Answer

A)  Factor V 
B)  Factor I 
C)  Factor VIII 
D)  Factor XIII 
E)  Factor XII 
A)  Factor V 
B)  Factor I 
C)  Factor VIII 
D)  Factor XIII 
E)  Factor XII

Question 14

All of the following factors are involved in the conversion of prothrombin to thrombin in the common pathway except:

Accepted Answer

A)  Factor V 
B)  Factor XI 
C)  Factor IV 
D)  PF3 
E)  None of the above 
A)  Factor V 
B)  Factor XI 
C)  Factor IV 
D)  PF3 
E)  None of the above

Question 15

All of the following generate plasmin formation except:

Accepted Answer

A)  Thrombin 
B)  Stuart-Prower factor 
C)  Prekallikrein 
D)  High-molecular-weight kininogen 
E)  None of the above 
A)  Thrombin 
B)  Stuart-Prower factor 
C)  Prekallikrein 
D)  High-molecular-weight kininogen 
E)  None of the above

Question 16

The prothrombin proteins are comprised of:

Accepted Answer

A)  Factors II, VIII, IX, X 
B)  Factors II, VII, IX, X 
C)  Factors I, VII, IX, X 
D)  Factors II, V, VII, X 
E)  None of the above 
A)  Factors II, VIII, IX, X 
B)  Factors II, VII, IX, X 
C)  Factors I, VII, IX, X 
D)  Factors II, V, VII, X 
E)  None of the above

Question 17

All of the following are major systems involved in maintaining hemostasis except:

Accepted Answer

A)  Vascular system 
B)  Kinin system 
C)  Platelets 
D)  Fibrin-forming (coagulation) system 
E)  Fibrin-lysing (fibrinolytic) system 
A)  Vascular system 
B)  Kinin system 
C)  Platelets 
D)  Fibrin-forming (coagulation) system 
E)  Fibrin-lysing (fibrinolytic) system

Question 18

The function of platelets in hemostasis includes which of the following?

Accepted Answer

A)  Maintenance of vascular integrity 
B)  Initial arrest of bleeding by platelet plug formation 
C)  Stabilization of the hemostatic plug by contributing to the process of fibrin formation 
D)  All of the above 
E)  None of the above 
A)  Maintenance of vascular integrity 
B)  Initial arrest of bleeding by platelet plug formation 
C)  Stabilization of the hemostatic plug by contributing to the process of fibrin formation 
D)  All of the above 
E)  None of the above

Question 19

Factor III is involved with which clotting pathway?

Accepted Answer

A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above 
A)  Intrinsic 
B)  Extrinsic 
C)  Common 
D)  A and B 
E)  All of the above

Question 20

Early fibrinogen degradation products (FDPs) consist of:

Accepted Answer

A)  D and E fragments 
B)  D and Y fragments 
C)  X monomer and Y fragments 
D)  X monomer and D fragments 
E)  X monomer and E fragments 
A)  D and E fragments 
B)  D and Y fragments 
C)  X monomer and Y fragments 
D)  X monomer and D fragments 
E)  X monomer and E fragments

Exam 24: Introduction to Hemostasis

The major portion of factor VIII is considered to be a carrier protein called __________.

What result will occur in the coagulation cascade if there is a deficiency of any one of the coagulation factors?

__________ functions as a potent vasodilator and inhibitor of the platelet response.

Late FDPs consist of:

What is the substrate of the coagulation system?

Platelets do not aggregate in Glanzmann's thrombasthenia when:

Bradykinins function to:

What is the correct sequence of events in hemostatic plug formation?

Adhesion of platelets to subendothelial fibers is dependent on a plasma protein called __________.

Characteristics of the contact group of coagulation proteins include:

Blood coagulation leading to fibrin formation is separated into the __________ and __________ pathways.

In the peripheral blood, approximately __________ percent of the platelets are sequestered in the spleen as functional reserves.

All of the following coagulation proteins make up the fibrinogen group except:

All of the following factors are involved in the conversion of prothrombin to thrombin in the common pathway except:

All of the following generate plasmin formation except:

The prothrombin proteins are comprised of:

All of the following are major systems involved in maintaining hemostasis except:

The function of platelets in hemostasis includes which of the following?

Factor III is involved with which clotting pathway?

Early fibrinogen degradation products (FDPs) consist of:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Blood coagulation leading to fibrin formation is separated into the and pathways.