Question 1

In hemophilia A patients, factor VIII:C should be maintained at a level of at least __________ percent of normal activity.

Accepted Answer

A)  50 
B)  30 
C)  10 
D)  40 
E)  None of the above 
A)  50 
B)  30 
C)  10 
D)  40 
E)  None of the above B

Question 2

Which laboratory test is abnormal in afibrinogenemia?

Accepted Answer

A)  TT 
B)  PT 
C)  APTT 
D)  Reptilase time 
E)  All of the above 
A)  TT 
B)  PT 
C)  APTT 
D)  Reptilase time 
E)  All of the above E

Question 3

All of the following are manifestations of afibrinogenemia except:

Accepted Answer

A)  Epistaxis 
B)  Umbilical cord blood bleeding 
C)  Gingival bleeding 
D)  Deep hematomas 
E)  Easy bruising 
A)  Epistaxis 
B)  Umbilical cord blood bleeding 
C)  Gingival bleeding 
D)  Deep hematomas 
E)  Easy bruising D

Question 4

Which factor is impaired in hemophilia A?

Accepted Answer

A)  VIII:Ag 
B)  VIII:vWF 
C)  VIII:C 
D)  All of the above 
E)  None of the above 
A)  VIII:Ag 
B)  VIII:vWF 
C)  VIII:C 
D)  All of the above 
E)  None of the above

Question 5

In the laboratory assessment of hemophilia B, the one-stage APTT factor assay for factor IX is __________.

Accepted Answer

A)  Increased 
B)  Normal 
C)  Decreased 
D)  Variable 
E)  None of the above 
A)  Increased 
B)  Normal 
C)  Decreased 
D)  Variable 
E)  None of the above

Question 6

The persistence of activated factor V in the circulation is caused by:

Accepted Answer

A)  Antithrombin III 
B)  Antiphospholipid antibodies 
C)  Activated protein C resistance 
D)  Dysfibrinogenemia 
E)  Protein C 
A)  Antithrombin III 
B)  Antiphospholipid antibodies 
C)  Activated protein C resistance 
D)  Dysfibrinogenemia 
E)  Protein C

Question 7

What do laboratory results demonstrate in factor V deficiencies?

Accepted Answer

A)  Prolonged PT, normal APTT 
B)  Prolonged PT and APTT 
C)  Normal PT 
D)  Normal APTT 
E)  None of the above 
A)  Prolonged PT, normal APTT 
B)  Prolonged PT and APTT 
C)  Normal PT 
D)  Normal APTT 
E)  None of the above

Question 8

Hemophilia A is a __________ disorder that affects approximately one male per 10,000 people in the world population.

Accepted Answer

A)  Autosomal dominant 
B)  Sex-linked recessive 
C)  Autosomal recessive 
D)  Sex-linked dominant 
E)  None of the above 
A)  Autosomal dominant 
B)  Sex-linked recessive 
C)  Autosomal recessive 
D)  Sex-linked dominant 
E)  None of the above

Question 9

In variant vWD, identification is essential for proper treatment. This can be accomplished by:

Accepted Answer

A)  Ristocetin-induced platelet aggregation studies 
B)  Multimeric analysis 
C)  Factor VIII:C, factor VIII:R Co, vWF:Ag 
D)  A and B 
E)  All of the above 
A)  Ristocetin-induced platelet aggregation studies 
B)  Multimeric analysis 
C)  Factor VIII:C, factor VIII:R Co, vWF:Ag 
D)  A and B 
E)  All of the above

Question 10

A factor X deficiency may result in all of the following except:

Accepted Answer

A)  Epistaxis 
B)  Gastrointestinal bleeding 
C)  Easy bruising 
D)  Hematomas 
E)  Hemarthroses 
A)  Epistaxis 
B)  Gastrointestinal bleeding 
C)  Easy bruising 
D)  Hematomas 
E)  Hemarthroses

Question 11

All of the following are laboratory findings consistent with hemophilia A except:

Accepted Answer

A)  Prolonged APTT 
B)  Prolonged bleeding time 
C)  Normal PT 
D)  Normal vWF:Ag 
E)  Normal platelet count 
A)  Prolonged APTT 
B)  Prolonged bleeding time 
C)  Normal PT 
D)  Normal vWF:Ag 
E)  Normal platelet count

Question 12

What statement is true regarding factor VIII?

Accepted Answer

A)  Factor VIII is absent in absorbed plasma. 
B)  Factor VIII is present in serum. 
C)  Factor VIII is vitamin K dependent. 
D)  Factor VIII is extremely thermolabile. 
E)  All of the above 
A)  Factor VIII is absent in absorbed plasma. 
B)  Factor VIII is present in serum. 
C)  Factor VIII is vitamin K dependent. 
D)  Factor VIII is extremely thermolabile. 
E)  All of the above

Question 13

Factor VIII:C is the __________ protein subunit of the factor VIII complex and represents the __________ or clotting activity of the complex.

Accepted Answer

A)  Smaller/procoagulant 
B)  Major/procoagulant 
C)  Major/von Willebrand factor activity 
D)  Smaller/von Willebrand activity 
E)  None of the above 
A)  Smaller/procoagulant 
B)  Major/procoagulant 
C)  Major/von Willebrand factor activity 
D)  Smaller/von Willebrand activity 
E)  None of the above

Question 14

What is the range of fibrinogen in patients with hypofibrinogenemia?

Accepted Answer

A)  20-100 mg/dL 
B)  200-400 mg/dL 
C)  50-100 mg/dL 
D)  100-350 mg/dL 
E)  None of the above 
A)  20-100 mg/dL 
B)  200-400 mg/dL 
C)  50-100 mg/dL 
D)  100-350 mg/dL 
E)  None of the above

Question 15

How does hemophilia B differ from hemophilia A?

Accepted Answer

A)  Inheritance 
B)  Bleeding sites 
C)  Bleeding time 
D)  Inhibitor production 
E)  None of the above 
A)  Inheritance 
B)  Bleeding sites 
C)  Bleeding time 
D)  Inhibitor production 
E)  None of the above

Question 16

The most common form of vWD is:

Accepted Answer

A)  Type 2B 
B)  Type 1 
C)  Type 3 
D)  Pseudo-platelet type 
E)  Type A 
A)  Type 2B 
B)  Type 1 
C)  Type 3 
D)  Pseudo-platelet type 
E)  Type A

Question 17

Acquired deficiencies of factor VII are associated with:

Accepted Answer

A)  Liver disease 
B)  Coumadin therapy 
C)  Vitamin K deficiency 
D)  All of the above 
E)  None of the above 
A)  Liver disease 
B)  Coumadin therapy 
C)  Vitamin K deficiency 
D)  All of the above 
E)  None of the above

Question 18

How is the level of factor VIII:C measured in the laboratory?

Accepted Answer

A)  A two-stage activated partial thromboplastin time (APTT)-based factor assay 
B)  A two-stage prothrombin time (PT)-based factor assay 
C)  A one-stage APTT-based factor assay 
D)  A one-stage PT-based factor assay 
E)  None of the above 
A)  A two-stage activated partial thromboplastin time (APTT)-based factor assay 
B)  A two-stage prothrombin time (PT)-based factor assay 
C)  A one-stage APTT-based factor assay 
D)  A one-stage PT-based factor assay 
E)  None of the above

Question 19

The reptilase time is a test that is used to differentiate the presence of __________ from a fibrinogen abnormality.

Accepted Answer

A)  Heparin 
B)  Coumarin 
C)  Warfarin 
D)  Lupus anticoagulant 
E)  All of the above 
A)  Heparin 
B)  Coumarin 
C)  Warfarin 
D)  Lupus anticoagulant 
E)  All of the above

Question 20

Which factor of the contact system, if deficient, may lead to a bleeding condition?

Accepted Answer

A)  Fitzgerald factor (high-molecular-weight kininogen) 
B)  Fletcher factor (prekallikrein) 
C)  Hageman factor (factor XII) 
D)  Plasma thromboplastin antecedent (factor XI) 
E)  None of the above 
A)  Fitzgerald factor (high-molecular-weight kininogen) 
B)  Fletcher factor (prekallikrein) 
C)  Hageman factor (factor XII) 
D)  Plasma thromboplastin antecedent (factor XI) 
E)  None of the above

Exam 26: Disorders of Plasma Clotting Factors

In hemophilia A patients, factor VIII:C should be maintained at a level of at least __________ percent of normal activity.

Which laboratory test is abnormal in afibrinogenemia?

All of the following are manifestations of afibrinogenemia except:

Which factor is impaired in hemophilia A?

In the laboratory assessment of hemophilia B, the one-stage APTT factor assay for factor IX is __________.

The persistence of activated factor V in the circulation is caused by:

What do laboratory results demonstrate in factor V deficiencies?

Hemophilia A is a __________ disorder that affects approximately one male per 10,000 people in the world population.

In variant vWD, identification is essential for proper treatment. This can be accomplished by:

A factor X deficiency may result in all of the following except:

All of the following are laboratory findings consistent with hemophilia A except:

What statement is true regarding factor VIII?

Factor VIII:C is the __________ protein subunit of the factor VIII complex and represents the __________ or clotting activity of the complex.

What is the range of fibrinogen in patients with hypofibrinogenemia?

How does hemophilia B differ from hemophilia A?

The most common form of vWD is:

Acquired deficiencies of factor VII are associated with:

How is the level of factor VIII:C measured in the laboratory?

The reptilase time is a test that is used to differentiate the presence of __________ from a fibrinogen abnormality.

Which factor of the contact system, if deficient, may lead to a bleeding condition?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

Filters

Factor VIII:C is the protein subunit of the factor VIII complex and represents the or clotting activity of the complex.