Question 1

From the standpoint of hematologic studies, the usual diagnostic criteria for the evaluation of anemias would be:

Accepted Answer

A)  Decreased hematocrit 
B)  Decreased hemoglobin 
C)  Decreased red blood cell (RB
C)  count 
D)  All of the above 
E)  None of the above 
A)  Decreased hematocrit 
B)  Decreased hemoglobin 
C)  Decreased red blood cell (RB
C)  count 
D)  All of the above 
E)  None of the above D

Question 2

Which physical symptoms may relate to moderate anemia?

Accepted Answer

A)  Fatigue 
B)  Dyspnea on exertion 
C)  Muscle weakness 
D)  Increased heart rate 
E)  All of the above 
A)  Fatigue 
B)  Dyspnea on exertion 
C)  Muscle weakness 
D)  Increased heart rate 
E)  All of the above E

Question 3

The adult hemoglobin reference range for men and women, respectively, is:

Accepted Answer

A)  16.0 ± 2 g/dL to 14.0 ± 2 g/dL 
B)  17.0 ± 2 g/dL to 12.0 ± 2 g/dL 
C)  14.0 ± 2 g/dL to 11.0 ± 2 g/dL 
D)  15.0 ± 2 g/dL to 16.0 ± 2 g/dL 
E)  None of the above 
A)  16.0 ± 2 g/dL to 14.0 ± 2 g/dL 
B)  17.0 ± 2 g/dL to 12.0 ± 2 g/dL 
C)  14.0 ± 2 g/dL to 11.0 ± 2 g/dL 
D)  15.0 ± 2 g/dL to 16.0 ± 2 g/dL 
E)  None of the above A

Question 4

Heinz bodies may be seen in what hematologic disease?

Accepted Answer

A)  Glucose 6-phosphate dehydrogenase (G6P
D)  deficiency 
B)  Alpha thalassemia 
C)  Unstable hemoglobinopathies 
D)  All of the above 
E)  None of the above 
A)  Glucose 6-phosphate dehydrogenase (G6P
D)  deficiency 
B)  Alpha thalassemia 
C)  Unstable hemoglobinopathies 
D)  All of the above 
E)  None of the above

Question 5

Which method for hemoglobin determination results in the formation of hemoglobin cyanide?

Accepted Answer

A)  Carboxyhemoglobin 
B)  Oxyhemoglobin 
C)  Sulfhemoglobin 
D)  Cyanmethemoglobin 
E)  None of the above 
A)  Carboxyhemoglobin 
B)  Oxyhemoglobin 
C)  Sulfhemoglobin 
D)  Cyanmethemoglobin 
E)  None of the above

Question 6

Polychromasia on the peripheral smear represents an increase in what cell and is a measure of the bone marrow's ability to replace red cells which have been destroyed?

Accepted Answer

A)  Pronormoblast 
B)  Reticulocyte 
C)  Basophilic normoblast 
D)  Orthochromic normoblast 
E)  None of the above 
A)  Pronormoblast 
B)  Reticulocyte 
C)  Basophilic normoblast 
D)  Orthochromic normoblast 
E)  None of the above

Question 7

The reference range for a reticulocyte count in a normal adult is:

Accepted Answer

A)  2.5-3.0% 
B)  0.5-2.0% 
C)  3.0-4.5% 
D)  1.0-3.0% 
E)  None of the above 
A)  2.5-3.0% 
B)  0.5-2.0% 
C)  3.0-4.5% 
D)  1.0-3.0% 
E)  None of the above

Question 8

A patient's hemoglobin is 12 g/dL. What would you expect the hematocrit to be?

Accepted Answer

A)  36% 
B)  33% 
C)  42% 
D)  39% 
E)  None of the above 
A)  36% 
B)  33% 
C)  42% 
D)  39% 
E)  None of the above

Question 9

What hemoglobin value would support the diagnosis of severe anemia?

Accepted Answer

A)  7-10 g/dL 
B)  12-14 g/dL 
C)  <7 g/dL 
D)  14-16 g/dL 
E)  None of the above 
A)  7-10 g/dL 
B)  12-14 g/dL 
C)  <7 g/dL 
D)  14-16 g/dL 
E)  None of the above

Question 10

What would be the classification of anemia when the MCV is equal to 70 fL?

Accepted Answer

A)  Macrocytic 
B)  Microcytic 
C)  Normocytic 
D)  Hypochromic 
E)  None of the above 
A)  Macrocytic 
B)  Microcytic 
C)  Normocytic 
D)  Hypochromic 
E)  None of the above

Question 11

What is the normal range for MCV?

Accepted Answer

A)  60-80 fL 
B)  40-60 fL 
C)  80-100 fL 
D)  100-120 fL 
E)  27-32 pg 
A)  60-80 fL 
B)  40-60 fL 
C)  80-100 fL 
D)  100-120 fL 
E)  27-32 pg

Question 12

Calculate the MCHC given the following: Hb = 9.0 g/dL, Hct = 27.4%:

Accepted Answer

A)  36% 
B)  33% 
C)  40% 
D)  31% 
E)  27% 
A)  36% 
B)  33% 
C)  40% 
D)  31% 
E)  27%

Question 13

A patient diagnosis with hereditary spherocytosis would have the following indices:

Accepted Answer

A)  Decreased MCHC 
B)  Increased MCHC 
C)  Increased MCV 
D)  Decreased MCH 
E)  None of the above 
A)  Decreased MCHC 
B)  Increased MCHC 
C)  Increased MCV 
D)  Decreased MCH 
E)  None of the above

Question 14

What is the mean corpuscular hemoglobin (MCH) used to measure?

Accepted Answer

A)  Packed cell volume 
B)  Average size of RBC 
C)  Iron content 
D)  Hemoglobin content 
E)  None of the above 
A)  Packed cell volume 
B)  Average size of RBC 
C)  Iron content 
D)  Hemoglobin content 
E)  None of the above

Question 15

What percentage of senescent circulating RBCs is lost daily in a healthy ambulatory individual?

Accepted Answer

A)  5% 
B)  3% 
C)  1% 
D)  7% 
E)  None of the above 
A)  5% 
B)  3% 
C)  1% 
D)  7% 
E)  None of the above

Question 16

What hemoglobin range will suggest a newborn patient?

Accepted Answer

A)  16 ± 4 g/dL 
B)  18 ± 4 g/dL 
C)  20 ± 2 g/dL 
D)  14 ± 2 g/dL 
E)  None of the above 
A)  16 ± 4 g/dL 
B)  18 ± 4 g/dL 
C)  20 ± 2 g/dL 
D)  14 ± 2 g/dL 
E)  None of the above

Question 17

A patient with microcytic anemia might have which of the following diseases?

Accepted Answer

A)  Iron-deficiency anemia 
B)  Sideroblastic anemia 
C)  Lead poisoning 
D)  Thalassemia 
E)  All of the above 
A)  Iron-deficiency anemia 
B)  Sideroblastic anemia 
C)  Lead poisoning 
D)  Thalassemia 
E)  All of the above

Question 18

In the presence of 2,3-diphosphoglycerate (2,3-DPG), hemoglobin can more readily release the oxygen it is carrying to peripheral tissues. In the state of chronic anemia, this compound is usually:

Accepted Answer

A)  Unchanged 
B)  Increased 
C)  Decreased 
D)  Change is regulated by pH 
E)  None of the above 
A)  Unchanged 
B)  Increased 
C)  Decreased 
D)  Change is regulated by pH 
E)  None of the above

Question 19

How many cells are usually counted in the manual reticulocyte count?

Accepted Answer

A)  100 
B)  1000 
C)  200 
D)  500 
E)  50 
A)  100 
B)  1000 
C)  200 
D)  500 
E)  50

Question 20

What disease state can be assessed by hemoglobin electrophoresis?

Accepted Answer

A)  RBC enzyme deficiency 
B)  Anemia of chronic disorders 
C)  Chronic leukemias 
D)  Hemoglobinopathies 
E)  None of the above 
A)  RBC enzyme deficiency 
B)  Anemia of chronic disorders 
C)  Chronic leukemias 
D)  Hemoglobinopathies 
E)  None of the above

Exam 4: Anemia: Diagnosis and Clinical Considerations

From the standpoint of hematologic studies, the usual diagnostic criteria for the evaluation of anemias would be:

Which physical symptoms may relate to moderate anemia?

The adult hemoglobin reference range for men and women, respectively, is:

Heinz bodies may be seen in what hematologic disease?

Which method for hemoglobin determination results in the formation of hemoglobin cyanide?

Polychromasia on the peripheral smear represents an increase in what cell and is a measure of the bone marrow's ability to replace red cells which have been destroyed?

The reference range for a reticulocyte count in a normal adult is:

A patient's hemoglobin is 12 g/dL. What would you expect the hematocrit to be?

What hemoglobin value would support the diagnosis of severe anemia?

What would be the classification of anemia when the MCV is equal to 70 fL?

What is the normal range for MCV?

Calculate the MCHC given the following: Hb = 9.0 g/dL, Hct = 27.4%:

A patient diagnosis with hereditary spherocytosis would have the following indices:

What is the mean corpuscular hemoglobin (MCH) used to measure?

What percentage of senescent circulating RBCs is lost daily in a healthy ambulatory individual?

What hemoglobin range will suggest a newborn patient?

A patient with microcytic anemia might have which of the following diseases?

In the presence of 2,3-diphosphoglycerate (2,3-DPG), hemoglobin can more readily release the oxygen it is carrying to peripheral tissues. In the state of chronic anemia, this compound is usually:

How many cells are usually counted in the manual reticulocyte count?

What disease state can be assessed by hemoglobin electrophoresis?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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