Question 1

Dehydration is an example of __________ erythrocytosis.

Accepted Answer

A)  Absolute 
B)  Relative 
C)  Secondary 
D)  Primary 
E)  None of the above 
A)  Absolute 
B)  Relative 
C)  Secondary 
D)  Primary 
E)  None of the above B

Question 2

In relative erythrocytosis, the red cell mass is __________.

Accepted Answer

A)  Decreased 
B)  Increased 
C)  Normal 
D)  All of the above 
E)  None of the above 
A)  Decreased 
B)  Increased 
C)  Normal 
D)  All of the above 
E)  None of the above C

Question 3

Which of the following characterizes the BM in the prefibrotic stage (p-CIMF) of CIMF according to the World Health Organization (WHO)?

Accepted Answer

A)  Decrease in erythroid precursors 
B)  Increase in granulocytic and megakaryocytic proliferation 
C)  Lack of fibrosis 
D)  Atypical megakaryocytes 
E)  All of the above 
A)  Decrease in erythroid precursors 
B)  Increase in granulocytic and megakaryocytic proliferation 
C)  Lack of fibrosis 
D)  Atypical megakaryocytes 
E)  All of the above E

Question 4

Anemia in CIMF is a collective result of:

Accepted Answer

A)  Bone marrow failure 
B)  Ineffective erythropoiesis 
C)  Dyserythropoiesis 
D)  All of the above 
E)  None of the above 
A)  Bone marrow failure 
B)  Ineffective erythropoiesis 
C)  Dyserythropoiesis 
D)  All of the above 
E)  None of the above

Question 5

A patient with myelofibrosis may develop early satisfaction for food intake due to:

Accepted Answer

A)  Thrombocytopenia 
B)  Hepatomegaly 
C)  Splenomegaly 
D)  Anemia 
E)  Infiltration of fibrotic cells in the stomach 
A)  Thrombocytopenia 
B)  Hepatomegaly 
C)  Splenomegaly 
D)  Anemia 
E)  Infiltration of fibrotic cells in the stomach

Question 6

Which factors constitute a diagnosis of polycythemia vera by the polycythemia vera study group guidelines?

Accepted Answer

A)  Elevated red cell mass 
B)  Normal arterial oxygen saturation 
C)  Splenomegaly 
D)  All of the above 
E)  None of the above 
A)  Elevated red cell mass 
B)  Normal arterial oxygen saturation 
C)  Splenomegaly 
D)  All of the above 
E)  None of the above

Question 7

Gaisböck's syndrome refers to hypertensive patients who present with increased red cell counts, plethora, and absence of splenomegaly. This relative polycythemia disorder is commonly referred to as:

Accepted Answer

A)  Stress erythrocytosis 
B)  Malignant erythrocytosis 
C)  Secondary erythrocytosis 
D)  Polycythemia vera 
E)  Primary erythrocytosis 
A)  Stress erythrocytosis 
B)  Malignant erythrocytosis 
C)  Secondary erythrocytosis 
D)  Polycythemia vera 
E)  Primary erythrocytosis

Question 8

All of the following are included in the classic findings of chronic idiopathic myelofibrosis (CIMF) except:

Accepted Answer

A)  Extramedullary hematopoiesis 
B)  Fibrosis of the marrow 
C)  Leukoerythroblastosis of the peripheral blood 
D)  Teardrop poikilocytosis of the peripheral blood 
E)  Erythroid hyperplasia 
A)  Extramedullary hematopoiesis 
B)  Fibrosis of the marrow 
C)  Leukoerythroblastosis of the peripheral blood 
D)  Teardrop poikilocytosis of the peripheral blood 
E)  Erythroid hyperplasia

Question 9

Which conditions are known to cause a possible false diagnosis of polycythemia vera?

Accepted Answer

A)  Heavy smoking 
B)  Alcoholic liver disease 
C)  Systemic lupus erythematosus 
D)  A and C 
E)  A and B 
A)  Heavy smoking 
B)  Alcoholic liver disease 
C)  Systemic lupus erythematosus 
D)  A and C 
E)  A and B

Question 10

In polycythemia vera, erythropoietin is __________.

Accepted Answer

A)  Decreased 
B)  Increased 
C)  Normal 
D)  All of the above 
E)  None of the above 
A)  Decreased 
B)  Increased 
C)  Normal 
D)  All of the above 
E)  None of the above

Question 11

What is the etiology of polycythemia vera?

Accepted Answer

A)  A physiologic response to an abnormal stimulus 
B)  Clonal hematologic malignancy of bone marrow 
C)  Idiopathic cause 
D)  An inherited hemoglobinopathy 
E)  An inherited oxygen affinity disorder 
A)  A physiologic response to an abnormal stimulus 
B)  Clonal hematologic malignancy of bone marrow 
C)  Idiopathic cause 
D)  An inherited hemoglobinopathy 
E)  An inherited oxygen affinity disorder

Question 12

In the fibrotic (f-CIMF) phase of CIMF, which of the following is characteristic?

Accepted Answer

A)  Fibrosis of the marrow 
B)  Extramedullary hematopoiesis 
C)  Leukoerythroblastosis of the peripheral blood 
D)  Splenomegaly 
E)  All of the above 
A)  Fibrosis of the marrow 
B)  Extramedullary hematopoiesis 
C)  Leukoerythroblastosis of the peripheral blood 
D)  Splenomegaly 
E)  All of the above

Question 13

Polycythemia vera is characterized by:

Accepted Answer

A)  Suppression of erythropoiesis and excessive proliferation of myeloid elements of the bone marrow 
B)  Accelerated erythropoiesis and excessive proliferation of myeloid and megakaryocytic elements of the bone marrow 
C)  Accelerated erythropoiesis and excessive proliferation of lymphoid elements in the bone marrow 
D)  Suppression of erythropoiesis and excessive proliferation of lymphoid elements of the bone marrow 
E)  All of the above 
A)  Suppression of erythropoiesis and excessive proliferation of myeloid elements of the bone marrow 
B)  Accelerated erythropoiesis and excessive proliferation of myeloid and megakaryocytic elements of the bone marrow 
C)  Accelerated erythropoiesis and excessive proliferation of lymphoid elements in the bone marrow 
D)  Suppression of erythropoiesis and excessive proliferation of lymphoid elements of the bone marrow 
E)  All of the above

Question 14

The Polycythemia Vera Study Group's (PVSG) updated criteria for the platelet count for diagnosis of essential thrombocythemia (ET) is which of the following?

Accepted Answer

A)  >400,000/µL 
B)  >700,000/µL 
C)  >100,000/µL 
D)  >600,000/µL 
E)  >500,000/µL 
A)  >400,000/µL 
B)  >700,000/µL 
C)  >100,000/µL 
D)  >600,000/µL 
E)  >500,000/µL

Question 15

Which phrase best describes the etiology of essential thrombocythemia?

Accepted Answer

A)  Chromosome defect 
B)  Physiologic response to an abnormal stimulus 
C)  Clonal disorder of the multipotential stem cell 
D)  Amino acid substitution in hemoglobin variants 
E)  None of the above 
A)  Chromosome defect 
B)  Physiologic response to an abnormal stimulus 
C)  Clonal disorder of the multipotential stem cell 
D)  Amino acid substitution in hemoglobin variants 
E)  None of the above

Question 16

Polycythemia vera has an insidious onset and is most often discovered through a __________ determination.

Accepted Answer

A)  White blood cell (WB
C)  count 
B)  Hematocrit 
C)  Reticulocyte count 
D)  Platelet count 
E)  Electrophoresis 
A)  White blood cell (WB
C)  count 
B)  Hematocrit 
C)  Reticulocyte count 
D)  Platelet count 
E)  Electrophoresis

Question 17

Persons living in high altitudes may present with what clinical features due to tissue hypoxia?

Accepted Answer

A)  Increased hematocrit 
B)  Ruddy cyanosis 
C)  Normocytic/normochromic erythrocytosis 
D)  Increased reticulocytes 
E)  All of the above 
A)  Increased hematocrit 
B)  Ruddy cyanosis 
C)  Normocytic/normochromic erythrocytosis 
D)  Increased reticulocytes 
E)  All of the above

Question 18

What bone marrow findings are usually seen in essential thrombocythemia?

Accepted Answer

A)  Trilineage hyperplasia 
B)  Large megakaryocytes 
C)  Stainable iron 
D)  Dysplastic megakaryocyte 
E)  All of the above 
A)  Trilineage hyperplasia 
B)  Large megakaryocytes 
C)  Stainable iron 
D)  Dysplastic megakaryocyte 
E)  All of the above

Question 19

Bone marrow aspiration in myelofibrosis frequently results in a __________.

Accepted Answer

A)  Clotted specimen 
B)  Dry tap 
C)  Hemolysis 
D)  Normal aspirate 
E)  None of the above 
A)  Clotted specimen 
B)  Dry tap 
C)  Hemolysis 
D)  Normal aspirate 
E)  None of the above

Question 20

What is/are the strongest differentiating feature(s) that distinguish chronic myelocytic leukemia (CML) from IMF?

Accepted Answer

A)  Decreased leukocyte alkaline phosphatase (LAP) 
B)  Presence of Philadelphia chromosome 
C)  Splenomegaly 
D)  A and B 
E)  B and C 
A)  Decreased leukocyte alkaline phosphatase (LAP) 
B)  Presence of Philadelphia chromosome 
C)  Splenomegaly 
D)  A and B 
E)  B and C

Exam 18: Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Dehydration is an example of __________ erythrocytosis.

In relative erythrocytosis, the red cell mass is __________.

Which of the following characterizes the BM in the prefibrotic stage (p-CIMF) of CIMF according to the World Health Organization (WHO)?

Anemia in CIMF is a collective result of:

A patient with myelofibrosis may develop early satisfaction for food intake due to:

Which factors constitute a diagnosis of polycythemia vera by the polycythemia vera study group guidelines?

Gaisböck's syndrome refers to hypertensive patients who present with increased red cell counts, plethora, and absence of splenomegaly. This relative polycythemia disorder is commonly referred to as:

All of the following are included in the classic findings of chronic idiopathic myelofibrosis (CIMF) except:

Which conditions are known to cause a possible false diagnosis of polycythemia vera?

In polycythemia vera, erythropoietin is __________.

What is the etiology of polycythemia vera?

In the fibrotic (f-CIMF) phase of CIMF, which of the following is characteristic?

Polycythemia vera is characterized by:

The Polycythemia Vera Study Group's (PVSG) updated criteria for the platelet count for diagnosis of essential thrombocythemia (ET) is which of the following?

Which phrase best describes the etiology of essential thrombocythemia?

Polycythemia vera has an insidious onset and is most often discovered through a __________ determination.

Persons living in high altitudes may present with what clinical features due to tissue hypoxia?

What bone marrow findings are usually seen in essential thrombocythemia?

Bone marrow aspiration in myelofibrosis frequently results in a __________.

What is/are the strongest differentiating feature(s) that distinguish chronic myelocytic leukemia (CML) from IMF?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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