Question 1

Heinz bodies are a result of:

Accepted Answer

A)  Denatured hemoglobin 
B)  Residual RNA 
C)  Residual DNA 
D)  Hemoglobin H 
E)  None of the above 
A)  Denatured hemoglobin 
B)  Residual RNA 
C)  Residual DNA 
D)  Hemoglobin H 
E)  None of the above A

Question 2

The mature erythrocyte, upon maturity, passes from a:

Accepted Answer

A)  Nucleated to non-nucleated state 
B)  Non-nucleated to nucleated state 
C)  Non-basophilic to basophilic state 
D)  Granulated to nongranulated cytoplasm 
E)  None of the above 
A)  Nucleated to non-nucleated state 
B)  Non-nucleated to nucleated state 
C)  Non-basophilic to basophilic state 
D)  Granulated to nongranulated cytoplasm 
E)  None of the above A

Question 3

A person diagnosed with lead poisoning may demonstrate:

Accepted Answer

A)  Basophilic stippling 
B)  Cabot rings 
C)  Tear drop cells 
D)  Howell-Jolly bodies 
E)  None of the above 
A)  Basophilic stippling 
B)  Cabot rings 
C)  Tear drop cells 
D)  Howell-Jolly bodies 
E)  None of the above A

Question 4

Which distinctive property is characteristic of a spherocyte?

Accepted Answer

A)  Hypochromia 
B)  Increased surface area-to-volume ratio 
C)  Decreased surface area-to-volume ratio 
D)  Visible central pallor 
E)  None of the above 
A)  Hypochromia 
B)  Increased surface area-to-volume ratio 
C)  Decreased surface area-to-volume ratio 
D)  Visible central pallor 
E)  None of the above

Question 5

Hypochromia is defined as any red cell having a central area of pallor of greater than which value?

Accepted Answer

A)  1 µm 
B)  2 µm 
C)  3 µm 
D)  5 µm 
E)  Any of the above 
A)  1 µm 
B)  2 µm 
C)  3 µm 
D)  5 µm 
E)  Any of the above

Question 6

Evaluation of macrocytosis on a peripheral blood smear should include:

Accepted Answer

A)  Shape 
B)  Presence of inclusions 
C)  Color 
D)  All of the above 
E)  None of the above 
A)  Shape 
B)  Presence of inclusions 
C)  Color 
D)  All of the above 
E)  None of the above

Question 7

Target cells may be found in which of the following conditions?

Accepted Answer

A)  Thalassemia 
B)  Liver disease 
C)  Hemoglobin C disease 
D)  Sickle cell anemia 
E)  All of the above 
A)  Thalassemia 
B)  Liver disease 
C)  Hemoglobin C disease 
D)  Sickle cell anemia 
E)  All of the above

Question 8

A patient diagnosed with autoimmune hemolytic anemia may have a blood smear demonstrating:

Accepted Answer

A)  Cabot rings 
B)  Spherocytes 
C)  Target cells 
D)  Stomatocytes 
E)  None of the above 
A)  Cabot rings 
B)  Spherocytes 
C)  Target cells 
D)  Stomatocytes 
E)  None of the above

Question 9

A microcyte is defined as having a diameter less than which value?

Accepted Answer

A)  8 µm 
B)  7 µm 
C)  10 µm 
D)  12 µm 
E)  None of the above 
A)  8 µm 
B)  7 µm 
C)  10 µm 
D)  12 µm 
E)  None of the above

Question 10

What might cause a microcytosis?

Accepted Answer

A)  Decreased globin synthesis 
B)  Decreased hemoglobin synthesis 
C)  Ineffective iron utilization 
D)  Deficiency of iron 
E)  All of the above 
A)  Decreased globin synthesis 
B)  Decreased hemoglobin synthesis 
C)  Ineffective iron utilization 
D)  Deficiency of iron 
E)  All of the above

Question 11

A patient diagnosed with anemia of chronic disorder would demonstrate:

Accepted Answer

A)  Macrocytosis 
B)  Microcytosis 
C)  Normocytosis 
D)  Sickled cells 
E)  None of the above 
A)  Macrocytosis 
B)  Microcytosis 
C)  Normocytosis 
D)  Sickled cells 
E)  None of the above

Question 12

What hematologic condition is associated with the appearance of Heinz bodies?

Accepted Answer

A)  Sickle cell anemia 
B)  Glucose 6-phosphate dehydrogenase (G6P
D)  deficiency 
C)  Liver disease 
D)  Aplastic anemia 
E)  None of the above 
A)  Sickle cell anemia 
B)  Glucose 6-phosphate dehydrogenase (G6P
D)  deficiency 
C)  Liver disease 
D)  Aplastic anemia 
E)  None of the above

Question 13

What is the average diameter of a mature erythrocyte?

Accepted Answer

A)  8-10 µm 
B)  3-5 µm 
C)  7-8 µm 
D)  4-6 µm 
E)  None of the above 
A)  8-10 µm 
B)  3-5 µm 
C)  7-8 µm 
D)  4-6 µm 
E)  None of the above

Question 14

A 4+ grading for anisocytosis would indicate what percentage of red blood cells (RBCs) would differ from the normal red cells?

Accepted Answer

A)  5-10% 
B)  25-50% 
C)  50-75% 
D)  >75% 
E)  10-25% 
A)  5-10% 
B)  25-50% 
C)  50-75% 
D)  >75% 
E)  10-25%

Question 15

All of the following are proposed mechanisms of macrocytosis except:

Accepted Answer

A)  Impaired DNA synthesis 
B)  Impaired RNA synthesis 
C)  Accelerated erythropoiesis 
D)  Increased membrane cholesterol and lecithin 
E)  None of the above 
A)  Impaired DNA synthesis 
B)  Impaired RNA synthesis 
C)  Accelerated erythropoiesis 
D)  Increased membrane cholesterol and lecithin 
E)  None of the above

Question 16

Codocyte is another name for which type of red cell?

Accepted Answer

A)  Drepanocyte 
B)  Ovalocyte 
C)  Sickle cell 
D)  Spherocyte 
E)  Target cells 
A)  Drepanocyte 
B)  Ovalocyte 
C)  Sickle cell 
D)  Spherocyte 
E)  Target cells

Question 17

Leukocytosis commonly refers to an increase in peripheral blood white blood cell (WBC) counts of greater than what value?

Accepted Answer

A)  5000 cells/F1F1F1S1F1F1F10L 
B)  1000 cells/F1F1F1S1F1F1F10L 
C)  10,000 cells/F1F1F1S1F1F1F10L 
D)  8000 cells/F1F1F1S1F1F1F10L 
E)  4000 cells/F1F1F1S1F1F1F10L 
A)  5000 cells/F1F1F1S1F1F1F10L 
B)  1000 cells/F1F1F1S1F1F1F10L 
C)  10,000 cells/F1F1F1S1F1F1F10L 
D)  8000 cells/F1F1F1S1F1F1F10L 
E)  4000 cells/F1F1F1S1F1F1F10L

Question 18

A 2+ grading for poikilocytosis would indicate what percentage of RBCs would differ from normal red cells?

Accepted Answer

A)  5-10% 
B)  25-50% 
C)  50-75% 
D)  >75% 
E)  10-25% 
A)  5-10% 
B)  25-50% 
C)  50-75% 
D)  >75% 
E)  10-25%

Question 19

What is the size of a normal platelet?

Accepted Answer

A)  6-7 F1F1F1S1F1F1F10m 
B)  4-6 F1F1F1S1F1F1F10m 
C)  7-8 F1F1F1S1F1F1F10m 
D)  2-4 F1F1F1S1F1F1F10m 
E)  0.5-1 F1F1F1S1F1F1F10m 
A)  6-7 F1F1F1S1F1F1F10m 
B)  4-6 F1F1F1S1F1F1F10m 
C)  7-8 F1F1F1S1F1F1F10m 
D)  2-4 F1F1F1S1F1F1F10m 
E)  0.5-1 F1F1F1S1F1F1F10m

Question 20

A tear-drop cell is formed as a result of:

Accepted Answer

A)  Red cell fragmentation 
B)  Pinching off a red cell inclusion 
C)  Increased lipids in red cell membrane 
D)  All of the above 
E)  None of the above 
A)  Red cell fragmentation 
B)  Pinching off a red cell inclusion 
C)  Increased lipids in red cell membrane 
D)  All of the above 
E)  None of the above

Exam 5: Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Heinz bodies are a result of:

The mature erythrocyte, upon maturity, passes from a:

A person diagnosed with lead poisoning may demonstrate:

Which distinctive property is characteristic of a spherocyte?

Hypochromia is defined as any red cell having a central area of pallor of greater than which value?

Evaluation of macrocytosis on a peripheral blood smear should include:

Target cells may be found in which of the following conditions?

A patient diagnosed with autoimmune hemolytic anemia may have a blood smear demonstrating:

A microcyte is defined as having a diameter less than which value?

What might cause a microcytosis?

A patient diagnosed with anemia of chronic disorder would demonstrate:

What hematologic condition is associated with the appearance of Heinz bodies?

What is the average diameter of a mature erythrocyte?

A 4+ grading for anisocytosis would indicate what percentage of red blood cells (RBCs) would differ from the normal red cells?

All of the following are proposed mechanisms of macrocytosis except:

Codocyte is another name for which type of red cell?

Leukocytosis commonly refers to an increase in peripheral blood white blood cell (WBC) counts of greater than what value?

A 2+ grading for poikilocytosis would indicate what percentage of RBCs would differ from normal red cells?

What is the size of a normal platelet?

A tear-drop cell is formed as a result of:

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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