Question 1

Clinical manifestations of infectious mononucleosis include:

Accepted Answer

A)  Sore throat 
B)  Fatigue 
C)  Lymphadenopathy 
D)  Joint pain dysphagia 
E)  All of the above 
A)  Sore throat 
B)  Fatigue 
C)  Lymphadenopathy 
D)  Joint pain dysphagia 
E)  All of the above E

Question 2

Which sequence reflects the correct order for phagocytosis?

Accepted Answer

A)  Release of cytoplasmic granules; binding of particle; ingestion; fusion of phagolysosome 
B)  Ingestion; binding of particles; fusion of phagolysosome; release of cytoplasmic granules 
C)  Binding of particle; ingestion; fusion of phagolysosome; release of cytoplasmic granules 
D)  Fusion of phagolysosome; binding of particle; release of cytoplasmic granules; ingestion 
A)  Release of cytoplasmic granules; binding of particle; ingestion; fusion of phagolysosome 
B)  Ingestion; binding of particles; fusion of phagolysosome; release of cytoplasmic granules 
C)  Binding of particle; ingestion; fusion of phagolysosome; release of cytoplasmic granules 
D)  Fusion of phagolysosome; binding of particle; release of cytoplasmic granules; ingestion C

Question 3

Slides containing malignant or suspicious lymphocyte morphology must be reviewed by a __________.

Accepted Answer

A)  Pathologist 
B)  Supervisor 
C)  Chief technologist 
D)  Peer technologist 
E)  None of the above 
A)  Pathologist 
B)  Supervisor 
C)  Chief technologist 
D)  Peer technologist 
E)  None of the above A

Question 4

Which other laboratory test(s) has/have significant correlation with infectious mononucleosis?

Accepted Answer

A)  AST 
B)  Alanine transferase (ALT) 
C)  Bilirubin 
D)  All of the above 
E)  None of the above 
A)  AST 
B)  Alanine transferase (ALT) 
C)  Bilirubin 
D)  All of the above 
E)  None of the above

Question 5

Reactive lymphocytes in infectious mononucleosis represent:

Accepted Answer

A)  Epstein Barr virus-infected B lymphocytes 
B)  T lymphocytes responding to infection 
C)  NK cells responding to infection 
D)  Plasma cells 
E)  None of the above 
A)  Epstein Barr virus-infected B lymphocytes 
B)  T lymphocytes responding to infection 
C)  NK cells responding to infection 
D)  Plasma cells 
E)  None of the above

Question 6

Newborns who are afflicted with a bacterial infection will develop severe neutropenia because of:

Accepted Answer

A)  Stem cell defect 
B)  The neutrophil storage pool being depleted in the bone marrow 
C)  Intramedullary destruction of precursors in the marrow 
D)  Dysfunctional chemotaxis 
E)  Gene mutation 
A)  Stem cell defect 
B)  The neutrophil storage pool being depleted in the bone marrow 
C)  Intramedullary destruction of precursors in the marrow 
D)  Dysfunctional chemotaxis 
E)  Gene mutation

Question 7

Most qualitative white blood cell disorders are characterized by:

Accepted Answer

A)  Bacterial infections due to decreased numbers of neutrophils 
B)  Bacterial infections due to increased numbers of neutrophils 
C)  Bacterial infections due to neutrophil dysfunction 
D)  Bacterial infections due to lymphocyte dysfunction 
E)  Lymphocyte infections due to lymphocyte dysfunction 
A)  Bacterial infections due to decreased numbers of neutrophils 
B)  Bacterial infections due to increased numbers of neutrophils 
C)  Bacterial infections due to neutrophil dysfunction 
D)  Bacterial infections due to lymphocyte dysfunction 
E)  Lymphocyte infections due to lymphocyte dysfunction

Question 8

During the first few days of a newborn's life, varying numbers of immature neutrophils can be identified in the blood. This is referred to as a:

Accepted Answer

A)  Shift to the right 
B)  Shift to the left 
C)  Chemotaxis 
D)  Leukocytosis 
E)  Leukemia 
A)  Shift to the right 
B)  Shift to the left 
C)  Chemotaxis 
D)  Leukocytosis 
E)  Leukemia

Question 9

Döhle bodies consist of __________.

Accepted Answer

A)  Endoplasmic reticulin 
B)  Cytoplasmic granules 
C)  Mucopolysaccharide 
D)  RNA 
E)  DNA 
A)  Endoplasmic reticulin 
B)  Cytoplasmic granules 
C)  Mucopolysaccharide 
D)  RNA 
E)  DNA

Question 10

Which of the following morphologies differentiates reactive lymphocyte from monocytes?

Accepted Answer

A)  Pale blue-gray cytoplasm 
B)  Even staining quality 
C)  Increased patchy basophilic cytoplasm 
D)  Cytoplasmic vacuolation 
E)  None of the above 
A)  Pale blue-gray cytoplasm 
B)  Even staining quality 
C)  Increased patchy basophilic cytoplasm 
D)  Cytoplasmic vacuolation 
E)  None of the above

Question 11

A patient with leukemia demonstrated bilobed neutrophils on a peripheral blood smear. These are often called:

Accepted Answer

A)  Pelger-Huët neutrophils 
B)  Pseudo-Pelger-Huët neutrophils 
C)  Hypersegmented neutrophils 
D)  Agranular neutrophils 
A)  Pelger-Huët neutrophils 
B)  Pseudo-Pelger-Huët neutrophils 
C)  Hypersegmented neutrophils 
D)  Agranular neutrophils

Question 12

What is the most common morphological change seen in neutrophils in response to bacterial infection?

Accepted Answer

A)  Auer rods 
B)  Cytoplasmic vacuolization 
C)  Dohle bodies 
D)  Toxic granulation 
E)  Agranulation 
A)  Auer rods 
B)  Cytoplasmic vacuolization 
C)  Dohle bodies 
D)  Toxic granulation 
E)  Agranulation

Question 13

Monocytosis occurs when the absolute monocyte count exceeds which of the following?

Accepted Answer

A)  2.0 F1F1F1S1F1F1F10 109 cells/L 
B)  0.2 F1F1F1S1F1F1F10 109 cells/L 
C)  1.0 F1F1F1S1F1F1F10 109 cells/L 
D)  5.0 F1F1F1S1F1F1F10 109 cells/L 
E)  0.5 F1F1F1S1F1F1F10 109 cells/L 
A)  2.0 F1F1F1S1F1F1F10 109 cells/L 
B)  0.2 F1F1F1S1F1F1F10 109 cells/L 
C)  1.0 F1F1F1S1F1F1F10 109 cells/L 
D)  5.0 F1F1F1S1F1F1F10 109 cells/L 
E)  0.5 F1F1F1S1F1F1F10 109 cells/L

Question 14

The size of a reactive lymphocyte is:

Accepted Answer

A)  5-10 µm 
B)  9-30 µm 
C)  80-100 µm 
D)  >100 µm 
E)  None of the above 
A)  5-10 µm 
B)  9-30 µm 
C)  80-100 µm 
D)  >100 µm 
E)  None of the above

Question 15

What is the function of opsonins?

Accepted Answer

A)  Oxidative destruction of cell membranes 
B)  To promote the interaction of the surface of microorganisms with receptors on the neutrophils membrane 
C)  Increase rate of biochemical reactions 
D)  To lower the resistance of invading organisms to the phagocytizing action of neutrophils 
E)  To stimulate leukopoiesis 
A)  Oxidative destruction of cell membranes 
B)  To promote the interaction of the surface of microorganisms with receptors on the neutrophils membrane 
C)  Increase rate of biochemical reactions 
D)  To lower the resistance of invading organisms to the phagocytizing action of neutrophils 
E)  To stimulate leukopoiesis

Question 16

The susceptibility to infections in Chédiak-Higashi disease is due to:

Accepted Answer

A)  Neutropenia 
B)  Impaired chemotaxis 
C)  Abnormal distribution of lysosomal enzymes 
D)  All of the above 
E)  None of the above 
A)  Neutropenia 
B)  Impaired chemotaxis 
C)  Abnormal distribution of lysosomal enzymes 
D)  All of the above 
E)  None of the above

Question 17

Additional serologic findings may be required to distinguish Epstein-Barr virus infection from which other viral infections?

Accepted Answer

A)  Rubella 
B)  Hepatitis 
C)  Cytomegalovirus 
D)  All of the above 
E)  None of the above 
A)  Rubella 
B)  Hepatitis 
C)  Cytomegalovirus 
D)  All of the above 
E)  None of the above

Question 18

What should be suspected when the left shift is seen in the presence of low leukocyte counts with 70% neutrophils?

Accepted Answer

A)  Multiple sclerosis 
B)  Leukemia 
C)  Septicemia 
D)  Pelger-Huët anomaly 
E)  Multiple myeloma 
A)  Multiple sclerosis 
B)  Leukemia 
C)  Septicemia 
D)  Pelger-Huët anomaly 
E)  Multiple myeloma

Question 19

A child with chronic benign neutropenia demonstrates an antibody in the serum directed at antigens on the patient's neutrophils. This finding is consistent with the presence of __________.

Accepted Answer

A)  Bacterial infection 
B)  Antineutrophil antibody 
C)  Parasitic infection 
D)  ABO blood group antibodies 
E)  Viral infection 
A)  Bacterial infection 
B)  Antineutrophil antibody 
C)  Parasitic infection 
D)  ABO blood group antibodies 
E)  Viral infection

Question 20

__________, seen in association with mucopolysaccharidosis, has characteristic dark staining and coarse cytoplasmic granules in the cytoplasm of neutrophils, lymphocytes, and monocytes.

Accepted Answer

A)  Alder-Reilly anomaly 
B)  May-Hegglin anomaly 
C)  Chédiak-Higashi disease 
D)  Pelger-Huët anomaly 
E)  None of the above 
A)  Alder-Reilly anomaly 
B)  May-Hegglin anomaly 
C)  Chédiak-Higashi disease 
D)  Pelger-Huët anomaly 
E)  None of the above

Exam 15: Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Clinical manifestations of infectious mononucleosis include:

Which sequence reflects the correct order for phagocytosis?

Slides containing malignant or suspicious lymphocyte morphology must be reviewed by a __________.

Which other laboratory test(s) has/have significant correlation with infectious mononucleosis?

Reactive lymphocytes in infectious mononucleosis represent:

Newborns who are afflicted with a bacterial infection will develop severe neutropenia because of:

Most qualitative white blood cell disorders are characterized by:

During the first few days of a newborn's life, varying numbers of immature neutrophils can be identified in the blood. This is referred to as a:

Döhle bodies consist of __________.

Which of the following morphologies differentiates reactive lymphocyte from monocytes?

A patient with leukemia demonstrated bilobed neutrophils on a peripheral blood smear. These are often called:

What is the most common morphological change seen in neutrophils in response to bacterial infection?

Monocytosis occurs when the absolute monocyte count exceeds which of the following?

The size of a reactive lymphocyte is:

What is the function of opsonins?

The susceptibility to infections in Chédiak-Higashi disease is due to:

Additional serologic findings may be required to distinguish Epstein-Barr virus infection from which other viral infections?

What should be suspected when the left shift is seen in the presence of low leukocyte counts with 70% neutrophils?

A child with chronic benign neutropenia demonstrates an antibody in the serum directed at antigens on the patient's neutrophils. This finding is consistent with the presence of __________.

__________, seen in association with mucopolysaccharidosis, has characteristic dark staining and coarse cytoplasmic granules in the cytoplasm of neutrophils, lymphocytes, and monocytes.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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