Question 1

Which of the following abnormal hemoglobins will have a positive tube solubility test?

Accepted Answer

A)  HbS 
B)  HbD 
C)  HbG 
D)  All of the above 
E)  None of the above 
A)  HbS 
B)  HbD 
C)  HbG 
D)  All of the above 
E)  None of the above A

Question 2

Hemoglobin is a conjugated protein with a molecular weight of approximately 68,000. It is composed of which of the following?

Accepted Answer

A)  Iron 
B)  Protoporphyrin IX type III 
C)  Globin 
D)  All of the above 
A)  Iron 
B)  Protoporphyrin IX type III 
C)  Globin 
D)  All of the above D

Question 3

Which of the following is characteristic of infections in patients with sickle cell anemia in comparison to healthy individuals?

Accepted Answer

A)  Disseminate more rapidly 
B)  Difficult to resolve 
C)  Associated with a greater morbidity 
D)  All of the above 
E)  None of the above 
A)  Disseminate more rapidly 
B)  Difficult to resolve 
C)  Associated with a greater morbidity 
D)  All of the above 
E)  None of the above D

Question 4

Which of the following represents inherited decreased affinity hemoglobins?

Accepted Answer

A)  Hb Chesapeake 
B)  HbS 
C)  HbC 
D)  Hb Kansas 
E)  Hb Rainier 
A)  Hb Chesapeake 
B)  HbS 
C)  HbC 
D)  Hb Kansas 
E)  Hb Rainier

Question 5

Which of the following represents a type of sickle cell crisis?

Accepted Answer

A)  Hemolytic 
B)  Aplastic 
C)  Painful (vaso-occlusive) 
D)  All of the above 
E)  None of the above 
A)  Hemolytic 
B)  Aplastic 
C)  Painful (vaso-occlusive) 
D)  All of the above 
E)  None of the above

Question 6

Which of the following rare hemoglobins also sickles, giving a positive tube solubility test?

Accepted Answer

A)  HbC Georgetown 
B)  HbS Memphis 
C)  Hb Porto-Alegre 
D)  All of the above 
E)  None of the above 
A)  HbC Georgetown 
B)  HbS Memphis 
C)  Hb Porto-Alegre 
D)  All of the above 
E)  None of the above

Question 7

Which of the following is characteristic of a hemolytic crisis in a sickle cell anemia patient?

Accepted Answer

A)  Decrease in hemoglobin 
B)  Decrease in hematocrit 
C)  Increase in reticulocyte count 
D)  Jaundice 
E)  All of the above 
A)  Decrease in hemoglobin 
B)  Decrease in hematocrit 
C)  Increase in reticulocyte count 
D)  Jaundice 
E)  All of the above

Question 8

Which of the following represents the standard principles of therapy in the management of painful crisis in a patient with sickle cell anemia?

Accepted Answer

A)  Adequate rehydration 
B)  Sufficient analgesics to relieve pain 
C)  Antibiotic therapy 
D)  All of the above 
E)  None of the above 
A)  Adequate rehydration 
B)  Sufficient analgesics to relieve pain 
C)  Antibiotic therapy 
D)  All of the above 
E)  None of the above

Question 9

Which of the following represents the only significant finding on the peripheral smear in hemoglobin C trait?

Accepted Answer

A)  Targeting 
B)  Hemoglobin C crystals 
C)  Nucleated red cells 
D)  4+ anisocytosis and poikilocytosis 
E)  All of the above 
A)  Targeting 
B)  Hemoglobin C crystals 
C)  Nucleated red cells 
D)  4+ anisocytosis and poikilocytosis 
E)  All of the above

Question 10

Which amino acid will differentiate hemoglobin C disease from normal HbA?

Accepted Answer

A)  Glycine 
B)  Leucine 
C)  Lysine 
D)  Arginine 
E)  Tyrosine 
A)  Glycine 
B)  Leucine 
C)  Lysine 
D)  Arginine 
E)  Tyrosine

Question 11

In hemoglobin SC disease what is the percentage of HbS and HbC found on the hemoglobin electrophoresis at alkaline pH?

Accepted Answer

A)  60:40 
B)  40:60 
C)  50:50 
D)  20:80 
E)  80:20 
A)  60:40 
B)  40:60 
C)  50:50 
D)  20:80 
E)  80:20

Question 12

Sickle cell trait represents what inherited form of the disease?

Accepted Answer

A)  Heterozygous 
B)  Homozygous 
C)  X-linked 
D)  Any of the above 
E)  None of the above 
A)  Heterozygous 
B)  Homozygous 
C)  X-linked 
D)  Any of the above 
E)  None of the above

Question 13

Which of the following is characteristic of hemoglobin O Arab?

Accepted Answer

A)  A rare hemoglobin variant that occurs infrequently in black, Arab, and Sudanese populations 
B)  Exhibits a mild hemolytic anemia 
C)  Exhibits slight splenomegaly 
D)  Target cells present on the peripheral blood smear 
E)  All of the above 
A)  A rare hemoglobin variant that occurs infrequently in black, Arab, and Sudanese populations 
B)  Exhibits a mild hemolytic anemia 
C)  Exhibits slight splenomegaly 
D)  Target cells present on the peripheral blood smear 
E)  All of the above

Question 14

What percentage of hemoglobin variants represents single amino acid substitutions in the globin chains?

Accepted Answer

A)  90% 
B)  10% 
C)  50% 
D)  20% 
A)  90% 
B)  10% 
C)  50% 
D)  20%

Question 15

What percentage of American blacks carry the hemoglobin C trait?

Accepted Answer

A)  0.02% 
B)  0.08% 
C)  2-3% 
D)  8-10% 
E)  20% 
A)  0.02% 
B)  0.08% 
C)  2-3% 
D)  8-10% 
E)  20%

Question 16

Which of the following represents major categories of hemoglobinopathies?

Accepted Answer

A)  Aggregating hemoglobins 
B)  Unbalanced synthesis of hemoglobin 
C)  Unstable hemoglobin 
D)  Hemoglobins with abnormal heme function 
E)  All of the above 
A)  Aggregating hemoglobins 
B)  Unbalanced synthesis of hemoglobin 
C)  Unstable hemoglobin 
D)  Hemoglobins with abnormal heme function 
E)  All of the above

Question 17

Hemoglobin E occurs with the greatest frequency in which of the following populations?

Accepted Answer

A)  Caucasian 
B)  Oriental 
C)  Black 
D)  Asian 
E)  Any of the above 
A)  Caucasian 
B)  Oriental 
C)  Black 
D)  Asian 
E)  Any of the above

Question 18

Which of the following defines methemoglobin?

Accepted Answer

A)  Hemoglobin with oxidized ferric iron (Fe3+) 
B)  Hemoglobin with ferrous iron (Fe2+) 
C)  Hemoglobin with carbon monoxide attached to heme 
D)  Hemoglobin with sulfide attached to heme 
E)  None of the above 
A)  Hemoglobin with oxidized ferric iron (Fe3+) 
B)  Hemoglobin with ferrous iron (Fe2+) 
C)  Hemoglobin with carbon monoxide attached to heme 
D)  Hemoglobin with sulfide attached to heme 
E)  None of the above

Question 19

Which of the following represents causes of methemoglobinemia?

Accepted Answer

A)  Hemoglobin M variants 
B)  NADH-diaphorase deficiency 
C)  Toxic substance 
D)  All of the above 
E)  None of the above 
A)  Hemoglobin M variants 
B)  NADH-diaphorase deficiency 
C)  Toxic substance 
D)  All of the above 
E)  None of the above

Question 20

Hemoglobin D migrates in the position of what other hemoglobin on hemoglobin electrophoresis at alkaline pH?

Accepted Answer

A)  HbS 
B)  HbA 
C)  HbA2 
D)  HbC 
E)  HbE 
A)  HbS 
B)  HbA 
C)  HbA2 
D)  HbC 
E)  HbE

Exam 11: Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Which of the following abnormal hemoglobins will have a positive tube solubility test?

Hemoglobin is a conjugated protein with a molecular weight of approximately 68,000. It is composed of which of the following?

Which of the following is characteristic of infections in patients with sickle cell anemia in comparison to healthy individuals?

Which of the following represents inherited decreased affinity hemoglobins?

Which of the following represents a type of sickle cell crisis?

Which of the following rare hemoglobins also sickles, giving a positive tube solubility test?

Which of the following is characteristic of a hemolytic crisis in a sickle cell anemia patient?

Which of the following represents the standard principles of therapy in the management of painful crisis in a patient with sickle cell anemia?

Which of the following represents the only significant finding on the peripheral smear in hemoglobin C trait?

Which amino acid will differentiate hemoglobin C disease from normal HbA?

In hemoglobin SC disease what is the percentage of HbS and HbC found on the hemoglobin electrophoresis at alkaline pH?

Sickle cell trait represents what inherited form of the disease?

Which of the following is characteristic of hemoglobin O Arab?

What percentage of hemoglobin variants represents single amino acid substitutions in the globin chains?

What percentage of American blacks carry the hemoglobin C trait?

Which of the following represents major categories of hemoglobinopathies?

Hemoglobin E occurs with the greatest frequency in which of the following populations?

Which of the following defines methemoglobin?

Which of the following represents causes of methemoglobinemia?

Hemoglobin D migrates in the position of what other hemoglobin on hemoglobin electrophoresis at alkaline pH?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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