Question 1

Which of the following is characteristic of hemoglobin E disease?

Accepted Answer

A)  Red cell indices indicate a microcytic hypochromic anemia. 
B)  Target cells are found on the peripheral smear. 
C)  95-97% HbE on the alkaline hemoglobin electrophoresis 
D)  No HbA 
E)  All of the above 
A)  Red cell indices indicate a microcytic hypochromic anemia. 
B)  Target cells are found on the peripheral smear. 
C)  95-97% HbE on the alkaline hemoglobin electrophoresis 
D)  No HbA 
E)  All of the above

Question 2

Which percentage of American blacks carry the trait (one gene) for hemoglobin S?

Accepted Answer

A)  0.16% 
B)  8-10% 
C)  20% 
D)  40% 
E)  50% 
A)  0.16% 
B)  8-10% 
C)  20% 
D)  40% 
E)  50%

Question 3

Although sickle cell trait is usually asymptomatic, sickling can still occur when caused by which of the following?

Accepted Answer

A)  Severe respiratory infection 
B)  Air travel in unpressurized aircraft 
C)  Anesthesia 
D)  Congestive heart failure 
E)  All of the above 
A)  Severe respiratory infection 
B)  Air travel in unpressurized aircraft 
C)  Anesthesia 
D)  Congestive heart failure 
E)  All of the above

Question 4

Methemoglobinemia is a clinical condition associated with levels greater than what percent of the total hemoglobin?

Accepted Answer

A)  0.1% 
B)  1% 
C)  0.01% 
D)  Any of the above 
E)  None of the above 
A)  0.1% 
B)  1% 
C)  0.01% 
D)  Any of the above 
E)  None of the above

Question 5

Sickle cell anemia represents the homozygous form of the disease in which the individual inherits how many abnormal genes that code for hemoglobin S?

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  4 
E)  Any of the above 
A)  1 
B)  2 
C)  3 
D)  4 
E)  Any of the above

Question 6

Which of the following clinical features is characteristic of sickle cell anemia?

Accepted Answer

A)  Severe anemia 
B)  Cardiac enlargement (cardiomegaly) 
C)  Icterus 
D)  Leukocytosis 
E)  All of the above 
A)  Severe anemia 
B)  Cardiac enlargement (cardiomegaly) 
C)  Icterus 
D)  Leukocytosis 
E)  All of the above

Question 7

Which of the following is characteristic of hemoglobin SC disease?

Accepted Answer

A)  Patients are generally less anemic than those with sickle cell anemia 
B)  Greater incidence of retinal hemorrhage 
C)  Greater incidence of renal papillary necrosis 
D)  Necrosis of the femoral head 
E)  All of the above 
A)  Patients are generally less anemic than those with sickle cell anemia 
B)  Greater incidence of retinal hemorrhage 
C)  Greater incidence of renal papillary necrosis 
D)  Necrosis of the femoral head 
E)  All of the above

Question 8

Which of the following is characteristic of methemoglobinemia?

Accepted Answer

A)  The blood may be chocolate-brown depending on the severity. 
B)  Cyanosis may result depending on the severity. 
C)  Hemoglobin iron in the oxidized ferric state is unable to carry or to bind oxygen. 
D)  All of the above 
E)  None of the above 
A)  The blood may be chocolate-brown depending on the severity. 
B)  Cyanosis may result depending on the severity. 
C)  Hemoglobin iron in the oxidized ferric state is unable to carry or to bind oxygen. 
D)  All of the above 
E)  None of the above

Question 9

Which of the following represents clinical manifestations of sickle cell anemia?

Accepted Answer

A)  Leg ulcers 
B)  Cardiomegaly 
C)  Joint and skeletal problems 
D)  Infarcts that can occur anywhere in the bone 
E)  All of the above 
A)  Leg ulcers 
B)  Cardiomegaly 
C)  Joint and skeletal problems 
D)  Infarcts that can occur anywhere in the bone 
E)  All of the above

Question 10

What is the frequency of hemoglobin C disease in American blacks in the United States?

Accepted Answer

A)  2-3% 
B)  1% 
C)  0.02% 
D)  15% 
E)  28% 
A)  2-3% 
B)  1% 
C)  0.02% 
D)  15% 
E)  28%

Question 11

Most hemoglobin variant traits without coexisting conditions of iron-deficiency anemia or thalassemia have approximately what percentage ratio of normal to abnormal hemoglobin?

Accepted Answer

A)  50:50 
B)  30:70 
C)  60:40 
D)  80:20 
E)  40:60 
A)  50:50 
B)  30:70 
C)  60:40 
D)  80:20 
E)  40:60

Question 12

The sickling process in sickle cell anemia can lead to which of the following clinical manifestations?

Accepted Answer

A)  Hypoxia 
B)  Painful crises 
C)  Infarction 
D)  Severe chronic hemolytic anemia 
E)  All of the above 
A)  Hypoxia 
B)  Painful crises 
C)  Infarction 
D)  Severe chronic hemolytic anemia 
E)  All of the above

Question 13

What is the most common pattern of inheritance for hemoglobinopathies?

Accepted Answer

A)  Autosomal dominant 
B)  Autosomal recessive 
C)  Codominant 
D)  X-linked 
E)  Any of the above 
A)  Autosomal dominant 
B)  Autosomal recessive 
C)  Codominant 
D)  X-linked 
E)  Any of the above

Question 14

The anemias of the hemoglobinopathies such as sickle cell are morphologically classified as:

Accepted Answer

A)  Microcytic hypochromic 
B)  Normocytic normochromic 
C)  Macrocytic 
D)  Microcytic normochromic 
E)  Any of the above 
A)  Microcytic hypochromic 
B)  Normocytic normochromic 
C)  Macrocytic 
D)  Microcytic normochromic 
E)  Any of the above

Question 15

Multiple infarctions and subsequent fibrosis of the spleen lead to what process in adult patients with sickle cell anemia?

Accepted Answer

A)  Splenomegaly 
B)  Hepatosplenomegaly 
C)  Autosplenectomy 
D)  Extramedullary hematopoiesis 
E)  All of the above 
A)  Splenomegaly 
B)  Hepatosplenomegaly 
C)  Autosplenectomy 
D)  Extramedullary hematopoiesis 
E)  All of the above

Exam 11: Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Which of the following is characteristic of hemoglobin E disease?

Which percentage of American blacks carry the trait (one gene) for hemoglobin S?

Although sickle cell trait is usually asymptomatic, sickling can still occur when caused by which of the following?

Methemoglobinemia is a clinical condition associated with levels greater than what percent of the total hemoglobin?

Sickle cell anemia represents the homozygous form of the disease in which the individual inherits how many abnormal genes that code for hemoglobin S?

Which of the following clinical features is characteristic of sickle cell anemia?

Which of the following is characteristic of hemoglobin SC disease?

Which of the following is characteristic of methemoglobinemia?

Which of the following represents clinical manifestations of sickle cell anemia?

What is the frequency of hemoglobin C disease in American blacks in the United States?

Most hemoglobin variant traits without coexisting conditions of iron-deficiency anemia or thalassemia have approximately what percentage ratio of normal to abnormal hemoglobin?

The sickling process in sickle cell anemia can lead to which of the following clinical manifestations?

What is the most common pattern of inheritance for hemoglobinopathies?

The anemias of the hemoglobinopathies such as sickle cell are morphologically classified as:

Multiple infarctions and subsequent fibrosis of the spleen lead to what process in adult patients with sickle cell anemia?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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