Question 1

What is the characteristic location of the tumor in endemic Burkitt's lymphoma of young children?

Accepted Answer

A)  Pancreas 
B)  Abdominal 
C)  Facial 
D)  Liver 
E)  None of the above 
A)  Pancreas 
B)  Abdominal 
C)  Facial 
D)  Liver 
E)  None of the above C

Question 2

Which Ann Arbor stage corresponds to disseminated involvement of extralymphatic organs with associated lymph node involvement?

Accepted Answer

A)  Stage I 
B)  Stage II 
C)  Stage III 
D)  Stage IV 
E)  None of the above 
A)  Stage I 
B)  Stage II 
C)  Stage III 
D)  Stage IV 
E)  None of the above D

Question 3

Small lymphocytic lymphoma is characterized by all of the following except:

Accepted Answer

A)  Indolent but incurable 
B)  Usually CD19+, CD5+, CD23+, CD10- 
C)  Growth centers 
D)  t(14;18) 
E)  Trisomy 12 
A)  Indolent but incurable 
B)  Usually CD19+, CD5+, CD23+, CD10- 
C)  Growth centers 
D)  t(14;18) 
E)  Trisomy 12 D

Question 4

The Ann Arbor staging system is used for all non-Hodgkin's lymphoma disorders except:

Accepted Answer

A)  Burkitt's lymphoma 
B)  Immunoblastic lymphoma 
C)  Lymphoblastic lymphoma 
D)  Cutaneous T-cell lymphoma 
E)  None of the above 
A)  Burkitt's lymphoma 
B)  Immunoblastic lymphoma 
C)  Lymphoblastic lymphoma 
D)  Cutaneous T-cell lymphoma 
E)  None of the above

Question 5

Burkitt's lymphoma is histologically characterized by which of the following?

Accepted Answer

A)  Uniform nuclei 
B)  High mitotic rate 
C)  "Starry sky" pattern 
D)  All of the above 
E)  None of the above 
A)  Uniform nuclei 
B)  High mitotic rate 
C)  "Starry sky" pattern 
D)  All of the above 
E)  None of the above

Question 6

Which type of malignant cell infiltrates the dermis and epidermis in Sézary syndrome and mycosis fungoides?

Accepted Answer

A)  T cell 
B)  B cell 
C)  Hairy cell 
D)  Plasma cell 
E)  Null cell 
A)  T cell 
B)  B cell 
C)  Hairy cell 
D)  Plasma cell 
E)  Null cell

Question 7

The diffuse aggressive lymphomas are:

Accepted Answer

A)  Seldom curable 
B)  Rapidly fatal if untreated 
C)  Best treated with a combination of surgery and radiotherapy 
D)  Single-agent chemotherapy is the treatment of choice. 
E)  All of the above 
A)  Seldom curable 
B)  Rapidly fatal if untreated 
C)  Best treated with a combination of surgery and radiotherapy 
D)  Single-agent chemotherapy is the treatment of choice. 
E)  All of the above

Question 8

All follicular center lymphomas are composed of a mixture of:

Accepted Answer

A)  Small cleaved and small non-cleaved cells 
B)  Centrocytes (small cleaved) and centroblasts (large non-cleaved) cells 
C)  Large cleaved cells and immunoblasts 
D)  Prolymphocytes and immunoblasts 
E)  All of the above 
A)  Small cleaved and small non-cleaved cells 
B)  Centrocytes (small cleaved) and centroblasts (large non-cleaved) cells 
C)  Large cleaved cells and immunoblasts 
D)  Prolymphocytes and immunoblasts 
E)  All of the above

Question 9

The lymphomas derived from intrafollicular lymphocytes most often express a(n) __________ phenotype.

Accepted Answer

A)  T-cell 
B)  B-cell 
C)  Null killer (NK) cell 
D)  Null cell 
E)  None of the above 
A)  T-cell 
B)  B-cell 
C)  Null killer (NK) cell 
D)  Null cell 
E)  None of the above

Question 10

Which of the following is true regarding the low-grade non-Hodgkin's lymphomas?

Accepted Answer

A)  Survival without treatment averages greater than 5 years. 
B)  Disease is usually advanced at diagnosis. 
C)  Multiagent chemotherapy can prolong survival. 
D)  Usually express B-cell phenotype 
E)  All of the above 
A)  Survival without treatment averages greater than 5 years. 
B)  Disease is usually advanced at diagnosis. 
C)  Multiagent chemotherapy can prolong survival. 
D)  Usually express B-cell phenotype 
E)  All of the above

Question 11

Which of the following are morphological characteristics of the Reed-Sternberg cell?

Accepted Answer

A)  Up to 45 µm in diameter 
B)  Multinucleated nucleus 
C)  Distinct halo around macronucleoli 
D)  None of the above 
E)  All of the above 
A)  Up to 45 µm in diameter 
B)  Multinucleated nucleus 
C)  Distinct halo around macronucleoli 
D)  None of the above 
E)  All of the above

Question 12

Lymphoblastic lymphomas are associated with which of the following?

Accepted Answer

A)  High frequency of developing acute lymphoblastic leukemia 
B)  Mediastinal mass 
C)  Potentially curable in young patients 
D)  Usually terminal deoxynucleotidyl transferase (TdT) positive 
E)  All of the above 
A)  High frequency of developing acute lymphoblastic leukemia 
B)  Mediastinal mass 
C)  Potentially curable in young patients 
D)  Usually terminal deoxynucleotidyl transferase (TdT) positive 
E)  All of the above

Question 13

The morphologic hallmark of Hodgkin's lymphoma is a peculiar cell called the __________ cell.

Accepted Answer

A)  Ann Arbor 
B)  Reed-Sternberg 
C)  Hairy cell 
D)  Rappaport 
E)  None of the above 
A)  Ann Arbor 
B)  Reed-Sternberg 
C)  Hairy cell 
D)  Rappaport 
E)  None of the above

Question 14

Non-Hodgkin's lymphomas are thought to be derived from lymphocytes present in the following lymph node compartments:

Accepted Answer

A)  Intrafollicular 
B)  Mantle zone 
C)  Marginal zone 
D)  Interfollicular 
E)  All of the above 
A)  Intrafollicular 
B)  Mantle zone 
C)  Marginal zone 
D)  Interfollicular 
E)  All of the above

Question 15

A lymphoma associated with infection by a type C retrovirus is:

Accepted Answer

A)  Endemic to Japan 
B)  Associated with hypercalcemia 
C)  Usually rapidly fatal 
D)  All of the above 
E)  None of the above 
A)  Endemic to Japan 
B)  Associated with hypercalcemia 
C)  Usually rapidly fatal 
D)  All of the above 
E)  None of the above

Question 16

What current view is accepted as the etiology for Hodgkin's disease?

Accepted Answer

A)  A malignant proliferation of Reed-Sternberg cells and their variants 
B)  A benign proliferation of Reed-Sternberg cells and their variants 
C)  A malignant proliferation of plasmacytoid lymphocytes and their variants 
D)  A benign proliferation of plasmacytoid lymphocytes and their variants 
E)  None of the above 
A)  A malignant proliferation of Reed-Sternberg cells and their variants 
B)  A benign proliferation of Reed-Sternberg cells and their variants 
C)  A malignant proliferation of plasmacytoid lymphocytes and their variants 
D)  A benign proliferation of plasmacytoid lymphocytes and their variants 
E)  None of the above

Question 17

A lymphoma expressing a monoclonal B-cell phenotype with coexpression of CD10 and rearrangement of the bcl-2 gene is most likely derived from:

Accepted Answer

A)  Follicular center cells 
B)  Mantle cells 
C)  Marginal zone cells 
D)  Interfollicular cells 
E)  None of the above 
A)  Follicular center cells 
B)  Mantle cells 
C)  Marginal zone cells 
D)  Interfollicular cells 
E)  None of the above

Question 18

The immunophenotyping definition of B cell monoclonality is:

Accepted Answer

A)  Clonal rearrangement of the IgH gene 
B)  Loss of B-cell antigens by the malignant cells 
C)  Expression of a single light chain class 
D)  Expression of a single heavy chain class 
E)  Clonal rearrangement of the light chain gene 
A)  Clonal rearrangement of the IgH gene 
B)  Loss of B-cell antigens by the malignant cells 
C)  Expression of a single light chain class 
D)  Expression of a single heavy chain class 
E)  Clonal rearrangement of the light chain gene

Question 19

All of the following are conditions associated with an increased risk of developing non-Hodgkin's lymphoma except:

Accepted Answer

A)  Sjögren's syndrome 
B)  Sarcoidosis 
C)  Niemann-Pick disease 
D)  Systemic lupus erythematosus 
E)  AIDS 
A)  Sjögren's syndrome 
B)  Sarcoidosis 
C)  Niemann-Pick disease 
D)  Systemic lupus erythematosus 
E)  AIDS

Question 20

An asymptomatic mediastinal mass affecting a young female is a common form of presentation for which form of Hodgkin's lymphoma?

Accepted Answer

A)  Lymphocyte-rich classic Hodgkin's lymphoma 
B)  Lymphocyte-predominant Hodgkin's lymphoma 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Lymphocyte-depleted Hodgkin's lymphoma 
E)  Nodular sclerosing Hodgkin's lymphoma 
A)  Lymphocyte-rich classic Hodgkin's lymphoma 
B)  Lymphocyte-predominant Hodgkin's lymphoma 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Lymphocyte-depleted Hodgkin's lymphoma 
E)  Nodular sclerosing Hodgkin's lymphoma

Exam 21: The Lymphomas

What is the characteristic location of the tumor in endemic Burkitt's lymphoma of young children?

Which Ann Arbor stage corresponds to disseminated involvement of extralymphatic organs with associated lymph node involvement?

Small lymphocytic lymphoma is characterized by all of the following except:

The Ann Arbor staging system is used for all non-Hodgkin's lymphoma disorders except:

Burkitt's lymphoma is histologically characterized by which of the following?

Which type of malignant cell infiltrates the dermis and epidermis in Sézary syndrome and mycosis fungoides?

The diffuse aggressive lymphomas are:

All follicular center lymphomas are composed of a mixture of:

The lymphomas derived from intrafollicular lymphocytes most often express a(n) __________ phenotype.

Which of the following is true regarding the low-grade non-Hodgkin's lymphomas?

Which of the following are morphological characteristics of the Reed-Sternberg cell?

Lymphoblastic lymphomas are associated with which of the following?

The morphologic hallmark of Hodgkin's lymphoma is a peculiar cell called the __________ cell.

Non-Hodgkin's lymphomas are thought to be derived from lymphocytes present in the following lymph node compartments:

A lymphoma associated with infection by a type C retrovirus is:

What current view is accepted as the etiology for Hodgkin's disease?

A lymphoma expressing a monoclonal B-cell phenotype with coexpression of CD10 and rearrangement of the bcl-2 gene is most likely derived from:

The immunophenotyping definition of B cell monoclonality is:

All of the following are conditions associated with an increased risk of developing non-Hodgkin's lymphoma except:

An asymptomatic mediastinal mass affecting a young female is a common form of presentation for which form of Hodgkin's lymphoma?

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Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

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Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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