Question 1

Which of the following cell types are commonly found in mixed cellularity Hodgkin's disease?

Accepted Answer

A)  Lymphocytes 
B)  Histiocytes 
C)  Plasma cells 
D)  Reed-Sternberg cells 
E)  All of the above 
A)  Lymphocytes 
B)  Histiocytes 
C)  Plasma cells 
D)  Reed-Sternberg cells 
E)  All of the above

Question 2

The selection of appropriate therapy for Hodgkin's lymphoma is most directly related to:

Accepted Answer

A)  Histologic subtype 
B)  Stage of the disease 
C)  Age of the patient 
D)  All of the above 
E)  None of the above 
A)  Histologic subtype 
B)  Stage of the disease 
C)  Age of the patient 
D)  All of the above 
E)  None of the above

Question 3

What name is given to the abnormal growth-regulating genes that on activation-deregulation play a major role in development of most lymphomas?

Accepted Answer

A)  Proto-oncogene 
B)  Oncogene 
C)  c-myc gene 
D)  All of the above 
E)  None of the above 
A)  Proto-oncogene 
B)  Oncogene 
C)  c-myc gene 
D)  All of the above 
E)  None of the above

Question 4

Which of the following are diseases in which Reed-Sternberg-like cells have been reported?

Accepted Answer

A)  Melanoma 
B)  Viral infection 
C)  Myeloproliferative disorders 
D)  Stromal malignancies 
E)  All of the above 
A)  Melanoma 
B)  Viral infection 
C)  Myeloproliferative disorders 
D)  Stromal malignancies 
E)  All of the above

Question 5

What is the morphologic characterization of the malignant cells in lymphomas composed of small cleaved lymphocytes?

Accepted Answer

A)  6-12 µm in diameter 
B)  Clefted nucleus 
C)  Indistinct nucleoli 
D)  Small amount of cytoplasm 
E)  All of the above 
A)  6-12 µm in diameter 
B)  Clefted nucleus 
C)  Indistinct nucleoli 
D)  Small amount of cytoplasm 
E)  All of the above

Question 6

In __________, Reed-Sternberg cells and Reed-Sternberg variants predominate; and lymphocytes are sparse.

Accepted Answer

A)  Lymphocyte predominance Hodgkin's lymphoma 
B)  Lymphocyte depletion Hodgkin's lymphoma 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Nodular sclerosing Hodgkin's lymphoma 
E)  Lymphocyte-rich classic Hodgkin's lymphoma 
A)  Lymphocyte predominance Hodgkin's lymphoma 
B)  Lymphocyte depletion Hodgkin's lymphoma 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Nodular sclerosing Hodgkin's lymphoma 
E)  Lymphocyte-rich classic Hodgkin's lymphoma

Question 7

Which infectious agent is most commonly associated with the pathogenesis of Hodgkin's disease?

Accepted Answer

A)  Echo virus 
B)  Herpes virus 
C)  Helicobacter pylori 
D)  Epstein-Barr virus 
E)  Picornavirus 
A)  Echo virus 
B)  Herpes virus 
C)  Helicobacter pylori 
D)  Epstein-Barr virus 
E)  Picornavirus

Question 8

The accepted etiology for non-Hodgkin's lymphoma is damage to the regions of genetic code that regulate the growth and reproduction of cells of the immune system. What mutagenic factor(s) play(s) a role in initiation of this damage?

Accepted Answer

A)  Chemicals 
B)  Ionizing radiation 
C)  Viruses 
D)  All of the above 
E)  None of the above 
A)  Chemicals 
B)  Ionizing radiation 
C)  Viruses 
D)  All of the above 
E)  None of the above

Question 9

Which name is given to the Reed-Sternberg variant cell seen in nodular sclerosing (NS) Hodgkin's lymphoma?

Accepted Answer

A)  Lacunar cell 
B)  Mott cells 
C)  Warthin-Finkeldey cell 
D)  L and H cell 
E)  Monocytoid B cell 
A)  Lacunar cell 
B)  Mott cells 
C)  Warthin-Finkeldey cell 
D)  L and H cell 
E)  Monocytoid B cell

Question 10

Which of the following are T-cell disorders?

Accepted Answer

A)  Mycosis fungoides 
B)  Sézary's syndrome 
C)  Hepatosplenic gamma/delta lymphoma 
D)  Angioimmunoblastic lymphadenopathy with dysproteinemia (AIL
D) -like T-cell lymphoma 
E)  All of the above 
A)  Mycosis fungoides 
B)  Sézary's syndrome 
C)  Hepatosplenic gamma/delta lymphoma 
D)  Angioimmunoblastic lymphadenopathy with dysproteinemia (AIL
D) -like T-cell lymphoma 
E)  All of the above

Question 11

Which classification system is most often used by clinicians in the characterization of non-Hodgkin's lymphoma?

Accepted Answer

A)  Rye 
B)  Working formulation 
C)  Ann Arbor 
D)  Lukes and Butler 
E)  None of the above 
A)  Rye 
B)  Working formulation 
C)  Ann Arbor 
D)  Lukes and Butler 
E)  None of the above

Question 12

Translocations involving the bcl-1 and IgH genes are commonly associated with which low-grade B cell lymphoma?

Accepted Answer

A)  Small lymphocytic 
B)  Immunocytoma 
C)  Mantle cell 
D)  Marginal cell 
E)  None of the above 
A)  Small lymphocytic 
B)  Immunocytoma 
C)  Mantle cell 
D)  Marginal cell 
E)  None of the above

Question 13

Alternatives to karyotypic analysis for the demonstration of chromosomal translocations include:

Accepted Answer

A)  Southern blot analysis 
B)  Polymerase chain reaction 
C)  Fluorescence in situ hybridization 
D)  All of the above 
E)  None of the above 
A)  Southern blot analysis 
B)  Polymerase chain reaction 
C)  Fluorescence in situ hybridization 
D)  All of the above 
E)  None of the above

Question 14

The diagnosis of Hodgkin's lymphoma requires a __________ and microscopic evaluation.

Accepted Answer

A)  Bone marrow aspirate 
B)  Tissue biopsy 
C)  Bone marrow biopsy 
D)  Peripheral blood smear 
E)  None of the above 
A)  Bone marrow aspirate 
B)  Tissue biopsy 
C)  Bone marrow biopsy 
D)  Peripheral blood smear 
E)  None of the above

Question 15

A commonly used classification scheme for Hodgkin's lymphoma is:

Accepted Answer

A)  Ann Arbor 
B)  Rappaport 
C)  Rye 
D)  Reed-Sternberg 
E)  None of the above 
A)  Ann Arbor 
B)  Rappaport 
C)  Rye 
D)  Reed-Sternberg 
E)  None of the above

Question 16

Most patients with Hodgkin's lymphoma present with which symptom?

Accepted Answer

A)  Fever 
B)  Painless lymph node swelling 
C)  Fatigue 
D)  Pallor 
E)  None of the above 
A)  Fever 
B)  Painless lymph node swelling 
C)  Fatigue 
D)  Pallor 
E)  None of the above

Question 17

With appropriate therapy the 10-year survival of Stage I and II Hodgkin's lymphoma is:

Accepted Answer

A)  0% 
B)  Less than 50% 
C)  Greater than 80% 
D)  100% 
E)  None of the above 
A)  0% 
B)  Less than 50% 
C)  Greater than 80% 
D)  100% 
E)  None of the above

Question 18

The malignant lymphomas are divided into which major categories?

Accepted Answer

A)  Hodgkin's lymphoma (disease) and non-Hodgkin's lymphomas (lymphocytic lymphomas) 
B)  Reticulum cell sarcomas lymphocytic lymphomas 
C)  Nodal and extracellular lymphomas 
D)  All of the above 
E)  None of the above 
A)  Hodgkin's lymphoma (disease) and non-Hodgkin's lymphomas (lymphocytic lymphomas) 
B)  Reticulum cell sarcomas lymphocytic lymphomas 
C)  Nodal and extracellular lymphomas 
D)  All of the above 
E)  None of the above

Question 19

The most frequently occurring subtype of Hodgkin's lymphoma is:

Accepted Answer

A)  Lymphocyte rich classic Hodgkin's lymphoma 
B)  Lymphocyte predominant 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Lymphocyte depleted Hodgkin's lymphoma 
E)  Nodular sclerosing Hodgkin's lymphoma 
A)  Lymphocyte rich classic Hodgkin's lymphoma 
B)  Lymphocyte predominant 
C)  Mixed cellularity Hodgkin's lymphoma 
D)  Lymphocyte depleted Hodgkin's lymphoma 
E)  Nodular sclerosing Hodgkin's lymphoma

Question 20

The most widely used staging system for Hodgkin's lymphoma is the __________ classification.

Accepted Answer

A)  Rye 
B)  Rappaport 
C)  Ann Arbor 
D)  Lukes and Butler 
E)  None of the above 
A)  Rye 
B)  Rappaport 
C)  Ann Arbor 
D)  Lukes and Butler 
E)  None of the above

Exam 21: The Lymphomas

Which of the following cell types are commonly found in mixed cellularity Hodgkin's disease?

The selection of appropriate therapy for Hodgkin's lymphoma is most directly related to:

What name is given to the abnormal growth-regulating genes that on activation-deregulation play a major role in development of most lymphomas?

Which of the following are diseases in which Reed-Sternberg-like cells have been reported?

What is the morphologic characterization of the malignant cells in lymphomas composed of small cleaved lymphocytes?

In __________, Reed-Sternberg cells and Reed-Sternberg variants predominate; and lymphocytes are sparse.

Which infectious agent is most commonly associated with the pathogenesis of Hodgkin's disease?

The accepted etiology for non-Hodgkin's lymphoma is damage to the regions of genetic code that regulate the growth and reproduction of cells of the immune system. What mutagenic factor(s) play(s) a role in initiation of this damage?

Which name is given to the Reed-Sternberg variant cell seen in nodular sclerosing (NS) Hodgkin's lymphoma?

Which of the following are T-cell disorders?

Which classification system is most often used by clinicians in the characterization of non-Hodgkin's lymphoma?

Translocations involving the bcl-1 and IgH genes are commonly associated with which low-grade B cell lymphoma?

Alternatives to karyotypic analysis for the demonstration of chromosomal translocations include:

The diagnosis of Hodgkin's lymphoma requires a __________ and microscopic evaluation.

A commonly used classification scheme for Hodgkin's lymphoma is:

Most patients with Hodgkin's lymphoma present with which symptom?

With appropriate therapy the 10-year survival of Stage I and II Hodgkin's lymphoma is:

The malignant lymphomas are divided into which major categories?

The most frequently occurring subtype of Hodgkin's lymphoma is:

The most widely used staging system for Hodgkin's lymphoma is the __________ classification.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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