Question 1

The normal myeloid-to-erythroid ratio in a bone marrow aspirate from a normal adult is approximately:

Accepted Answer

A)  1:1 
B)  2:1 
C)  4:1 
D)  6:1 
E)  None of the above 
A)  1:1 
B)  2:1 
C)  4:1 
D)  6:1 
E)  None of the above C

Question 2

Which blood cell aids hematopoiesis by the direct transfer of iron to erythroid precursors?

Accepted Answer

A)  Monocyte 
B)  Macrophage 
C)  Erythrocyte 
D)  Lymphocyte 
E)  None of the above 
A)  Monocyte 
B)  Macrophage 
C)  Erythrocyte 
D)  Lymphocyte 
E)  None of the above B

Question 3

In a normal adult hematopoiesis is observed primarily in which location?

Accepted Answer

A)  Liver 
B)  Spleen 
C)  Yolk sac 
D)  Bone marrow 
E)  Lymph nodes 
A)  Liver 
B)  Spleen 
C)  Yolk sac 
D)  Bone marrow 
E)  Lymph nodes D

Question 4

Hematogones are thought to be committed progenitor cells of what lineage?

Accepted Answer

A)  Granulocytic 
B)  Platelets 
C)  Erythrocytic 
D)  Monocytic 
E)  Lymphoid 
A)  Granulocytic 
B)  Platelets 
C)  Erythrocytic 
D)  Monocytic 
E)  Lymphoid

Question 5

Under which magnification should bone marrow initially be examined?

Accepted Answer

A)  (F1F1F1S1F1F1F1040) 
B) ( F1F1F1S1F1F1F104) 
C)  (F1F1F1S1F1F1F1010) 
D)  (F1F1F1S1F1F1F10100) 
E)  None of the above 
A)  (F1F1F1S1F1F1F1040) 
B) ( F1F1F1S1F1F1F104) 
C)  (F1F1F1S1F1F1F1010) 
D)  (F1F1F1S1F1F1F10100) 
E)  None of the above

Question 6

On Wright's stain hemosiderin will stain as:

Accepted Answer

A)  Brownish-blue 
B)  Golden-yellow 
C)  Reddish-orange 
D)  Purple 
E)  None of the above 
A)  Brownish-blue 
B)  Golden-yellow 
C)  Reddish-orange 
D)  Purple 
E)  None of the above

Question 7

The presence of megakaryocytes clusters and promegakaryocytes in every field of a bone marrow differential is indicative of:

Accepted Answer

A)  Megakaryocytic hypoplasia 
B)  Thrombocytopenia 
C)  Megakaryocytic hyperplasia 
D)  Christmas disease 
E)  None of the above 
A)  Megakaryocytic hypoplasia 
B)  Thrombocytopenia 
C)  Megakaryocytic hyperplasia 
D)  Christmas disease 
E)  None of the above

Question 8

Which of the following nondividing cells comprise the granulocytic maturation storage pool in the bone marrow?

Accepted Answer

A)  Segmented neutrophils 
B)  Bands 
C)  Metamyelocytes 
D)  All of the above 
E)  None of the above 
A)  Segmented neutrophils 
B)  Bands 
C)  Metamyelocytes 
D)  All of the above 
E)  None of the above

Question 9

Under appropriate stimulation the mature lymphocytes of the peripheral lymphoid organs undergo

Accepted Answer

A)  Antigen-dependent effect on cell proliferation 
B)  Kinin or antibody production 
C)  Antibody production only 
D)  A and B 
E)  All of the above 
A)  Antigen-dependent effect on cell proliferation 
B)  Kinin or antibody production 
C)  Antibody production only 
D)  A and B 
E)  All of the above

Question 10

Why is a clotted marrow specimen unacceptable for hematologic smears?

Accepted Answer

A)  Cells would not stain. 
B)  Fibrin threads would impede spreading. 
C)  Fluid would be discolored. 
D)  All of the above 
E)  None of the above 
A)  Cells would not stain. 
B)  Fibrin threads would impede spreading. 
C)  Fluid would be discolored. 
D)  All of the above 
E)  None of the above

Question 11

In adults, fat cells average about what percentage of the total volume in the vertebrae and flat bones of the pelvis?

Accepted Answer

A)  20% 
B)  80% 
C)  50% 
D)  10% 
E)  90% 
A)  20% 
B)  80% 
C)  50% 
D)  10% 
E)  90%

Question 12

An increase in erythroid cellularity without disruption of the normal myeloid-to-erythroid ratio is termed:

Accepted Answer

A)  Erythrocytic hypoplasia 
B)  Erythrocytic hyperplasia 
C)  Granulocytic hyperplasia 
D)  Granulocytic hypoplasia 
E)  None of the above 
A)  Erythrocytic hypoplasia 
B)  Erythrocytic hyperplasia 
C)  Granulocytic hyperplasia 
D)  Granulocytic hypoplasia 
E)  None of the above

Question 13

At what age do fat cells begin to increase in the bone marrow?

Accepted Answer

A)  10 years 
B)  6 months 
C)  4 years 
D)  2 years 
E)  None of the above 
A)  10 years 
B)  6 months 
C)  4 years 
D)  2 years 
E)  None of the above

Question 14

Which of the following granulocytic cells are included in the proliferating pool of the bone marrow?

Accepted Answer

A)  Myeloblasts 
B)  Promyelocytes 
C)  Myelocytes 
D)  All of the above 
E)  None of the above 
A)  Myeloblasts 
B)  Promyelocytes 
C)  Myelocytes 
D)  All of the above 
E)  None of the above

Question 15

What is the main function of the bone marrow?

Accepted Answer

A)  To provide oxygenated cells to the tissues 
B)  Self-renewal of stromal cells 
C)  To maintain a steady supply of mature hematopoietic cells to circulation 
D)  To regulate iron storage and transfer 
E)  None of the above 
A)  To provide oxygenated cells to the tissues 
B)  Self-renewal of stromal cells 
C)  To maintain a steady supply of mature hematopoietic cells to circulation 
D)  To regulate iron storage and transfer 
E)  None of the above

Question 16

How is iron stored in the bone marrow?

Accepted Answer

A)  Hemosiderin 
B)  Transferrin 
C)  Ferritin 
D)  Erythropoietin 
E)  None of the above 
A)  Hemosiderin 
B)  Transferrin 
C)  Ferritin 
D)  Erythropoietin 
E)  None of the above

Question 17

Why is the bone biopsy the most reliable assessment of cellularity?

Accepted Answer

A)  A large amount of tissue is evaluated. 
B)  A small amount of tissue is evaluated. 
C)  It offers a more sterile procedure. 
D)  Marrow iron can be demonstrated with appropriate stain. 
E)  None of the above 
A)  A large amount of tissue is evaluated. 
B)  A small amount of tissue is evaluated. 
C)  It offers a more sterile procedure. 
D)  Marrow iron can be demonstrated with appropriate stain. 
E)  None of the above

Question 18

Which would be the appropriate site for marrow studies in a young child?

Accepted Answer

A)  Upper tibial bone 
B)  Lower tibial bone 
C)  Iliac crest 
D)  Sternum 
E)  None of the above 
A)  Upper tibial bone 
B)  Lower tibial bone 
C)  Iliac crest 
D)  Sternum 
E)  None of the above

Question 19

One-third of all circulating platelets are sequestered in which organ?

Accepted Answer

A)  Bone marrow 
B)  Lymph nodes 
C)  Spleen 
D)  Thymus 
E)  Liver 
A)  Bone marrow 
B)  Lymph nodes 
C)  Spleen 
D)  Thymus 
E)  Liver

Question 20

How many nucleated cells must be classified in a bone marrow differential count?

Accepted Answer

A)  50-100 
B)  100-500 
C)  500-1000 
D)  >1000 
E)  None of the above 
A)  50-100 
B)  100-500 
C)  500-1000 
D)  >1000 
E)  None of the above

Exam 2: Bone Marrow

The normal myeloid-to-erythroid ratio in a bone marrow aspirate from a normal adult is approximately:

Which blood cell aids hematopoiesis by the direct transfer of iron to erythroid precursors?

In a normal adult hematopoiesis is observed primarily in which location?

Hematogones are thought to be committed progenitor cells of what lineage?

Under which magnification should bone marrow initially be examined?

On Wright's stain hemosiderin will stain as:

The presence of megakaryocytes clusters and promegakaryocytes in every field of a bone marrow differential is indicative of:

Which of the following nondividing cells comprise the granulocytic maturation storage pool in the bone marrow?

Under appropriate stimulation the mature lymphocytes of the peripheral lymphoid organs undergo

Why is a clotted marrow specimen unacceptable for hematologic smears?

In adults, fat cells average about what percentage of the total volume in the vertebrae and flat bones of the pelvis?

An increase in erythroid cellularity without disruption of the normal myeloid-to-erythroid ratio is termed:

At what age do fat cells begin to increase in the bone marrow?

Which of the following granulocytic cells are included in the proliferating pool of the bone marrow?

What is the main function of the bone marrow?

How is iron stored in the bone marrow?

Why is the bone biopsy the most reliable assessment of cellularity?

Which would be the appropriate site for marrow studies in a young child?

One-third of all circulating platelets are sequestered in which organ?

How many nucleated cells must be classified in a bone marrow differential count?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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