Exam 19: Myelodysplastic Syndromes

Which type of MDS demonstrates a mild decreased white blood cell (WBC) count (3.9  10/L), increased erythropoiesis and normal numbers of blast cells in the marrow, and <15% sideroblasts?

The fundamental characteristic of MDS is:

The French-American-British (FAB) classification system separates the myelodysplastic syndromes into __________ different types.

The myeloid-to-erythroid ratio in MDS:

A type III sideroblast in dyserythropoiesis is demonstrated by:

Which MDS classification has the best prognosis?

Which of the following represents the "cornerstone" of myelodysplastic-syndrome treatment?

What is the purpose of transfusing granulocytes to a patient with RA?

Which factor(s) differentiate(s) RARS (refractory anemia with ringed sideroblasts) from refractory anemia?

Which is the most current system used for scoring MDS?

In calculating the percentage of myeloblasts in the bone marrow, the following data are given. Erythroid nuclear precursors (E) = 65%, myeloblasts = 14%, other cells = 21%. Based on these numbers, what is the percentage of myeloblasts by the FAB classification?

Which of the following is most likely to affect prognosis in MDS?

What characterizes the cytogenetic analysis of patients with MDS?

The most promising course of therapy for MDS is __________.

Which of the following is the most significant prognostic indicator in MDS?

RAEB contains a maximum of __________ blasts in the bone marrow.

What specific features are characteristic of dysmegakaryocytopoiesis morphology in MDS (myelodysplastic syndrome)?

MDS occurs more often in which age group?

Which of the following agents may lead to secondary myelodysplastic syndrome (sMDS)?

The most common and consistent nonrandom chromosomal aberration in the MDS, refractory anemia is deletion of the long arm of __________.