Question 1

Chromosomal abnormalities are directly correlated with the presence of the __________ population in patients with MDS.

Accepted Answer

A)  Promyelocyte 
B)  Blast 
C)  Megakaryocyte 
D)  Erythrocyte 
E)  None of the above 
A)  Promyelocyte 
B)  Blast 
C)  Megakaryocyte 
D)  Erythrocyte 
E)  None of the above

Question 2

The following morphologies are characteristic of dyserythropoiesis in MDS:

Accepted Answer

A)  Basophilic stippling 
B)  Normochromic, normocytic red cells 
C)  Multinuclearity 
D)  A and C 
E)  A, B, and C 
A)  Basophilic stippling 
B)  Normochromic, normocytic red cells 
C)  Multinuclearity 
D)  A and C 
E)  A, B, and C

Question 3

In female patients with RA and elevated platelet counts, which chromosome abnormality is most often found?

Accepted Answer

A)  (5q-) 
B)  t(8;21) 
C)  (7q-) 
D)  t(15;17) 
E)  t(9;22) 
A)  (5q-) 
B)  t(8;21) 
C)  (7q-) 
D)  t(15;17) 
E)  t(9;22)

Question 4

Which specific features are characteristic of dysgranulopoiesis morphology in MDS?

Accepted Answer

A)  Hypergranulation 
B)  Pure Pelger-Huët anomaly 
C)  Auer rods 
D)  Hypersegmentation in bone marrow 
E)  None of the above 
A)  Hypergranulation 
B)  Pure Pelger-Huët anomaly 
C)  Auer rods 
D)  Hypersegmentation in bone marrow 
E)  None of the above

Question 5

Which of the MDS subtypes is more closely related to the chronic myeloproliferative disorders?

Accepted Answer

A)  RAEB 
B)  CMML with WBC > 13 F1F1F1S1F1F1F10 109/L 
C)  CMML with WBC 9/L 
D)  RARS 
E)  None of the above 
A)  RAEB 
B)  CMML with WBC > 13 F1F1F1S1F1F1F10 109/L 
C)  CMML with WBC 9/L 
D)  RARS 
E)  None of the above

Question 6

Which of the following biological and/or genetic anomalies are important in the pathogenesis of MDS?

Accepted Answer

A)  Chromosomal translocations 
B)  Chromosomal deletions 
C)  Hemolysis 
D)  Increased intramedullary apoptosis 
E)  B and D 
A)  Chromosomal translocations 
B)  Chromosomal deletions 
C)  Hemolysis 
D)  Increased intramedullary apoptosis 
E)  B and D

Question 7

Ringed sideroblasts (type III) are seen in what MDS classification?

Accepted Answer

A)  RA 
B)  RAEB 
C)  RAEB-T 
D)  RARS 
E)  None of the above 
A)  RA 
B)  RAEB 
C)  RAEB-T 
D)  RARS 
E)  None of the above

Question 8

Which MDS classification has the worst prognosis?

Accepted Answer

A)  Refractory anemia with excess blasts in transformation (RAEB-T) 
B)  Refractory anemia (R
A)  
C)  Chronic myelomonocytic leukemia (CMML) 
D)  Refractory anemia with excess blasts (RAE
B)  
E)  None of the above 
A)  Refractory anemia with excess blasts in transformation (RAEB-T) 
B)  Refractory anemia (R
A)  
C)  Chronic myelomonocytic leukemia (CMML) 
D)  Refractory anemia with excess blasts (RAE
B)  
E)  None of the above

Exam 19: Myelodysplastic Syndromes

Chromosomal abnormalities are directly correlated with the presence of the __________ population in patients with MDS.

The following morphologies are characteristic of dyserythropoiesis in MDS:

In female patients with RA and elevated platelet counts, which chromosome abnormality is most often found?

Which specific features are characteristic of dysgranulopoiesis morphology in MDS?

Which of the MDS subtypes is more closely related to the chronic myeloproliferative disorders?

Which of the following biological and/or genetic anomalies are important in the pathogenesis of MDS?

Ringed sideroblasts (type III) are seen in what MDS classification?

Which MDS classification has the worst prognosis?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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