Question 1

What is the function of thrombin?

Accepted Answer

A)  Convert fibrinogen to fibrin 
B)  Activate factor XIII 
C)  Enhance factor V and VIII activity 
D)  Aggregate more platelets 
E)  All of the above 
A)  Convert fibrinogen to fibrin 
B)  Activate factor XIII 
C)  Enhance factor V and VIII activity 
D)  Aggregate more platelets 
E)  All of the above

Question 2

The average diameter of the platelet is __________.

Accepted Answer

A)  2-4 µm 
B)  6-8 µm 
C)  10-12 µm 
D)  18-20 µm 
E)  None of the above 
A)  2-4 µm 
B)  6-8 µm 
C)  10-12 µm 
D)  18-20 µm 
E)  None of the above

Question 3

The physiologic process of removing unwanted fibrin deposits represents a gradual progressive enzymatic cleavage of fibrin to soluble fragments. This process is termed __________.

Accepted Answer

A)  Coagulation 
B)  Hemostasis 
C)  Fibrinolysis 
D)  Disseminated intravascular coagulation (DI
C)  
E)  Thrombosis 
A)  Coagulation 
B)  Hemostasis 
C)  Fibrinolysis 
D)  Disseminated intravascular coagulation (DI
C)  
E)  Thrombosis

Question 4

What is the coagulation factor assigned as factor VII?

Accepted Answer

A)  Stabile factor 
B)  Prothrombin 
C)  Labile factor 
D)  Fibrinogen 
E)  None of the above 
A)  Stabile factor 
B)  Prothrombin 
C)  Labile factor 
D)  Fibrinogen 
E)  None of the above

Question 5

What is meant by the term viscous metamorphosis?

Accepted Answer

A)  An irreversible aggregation of a mass of degenerative platelet material without membrane 
B)  A reversible aggregation of a mass of degenerative platelet material without membrane 
C)  Inhibition of the initial aggregation of platelets 
D)  Inhibition of an irreversible aggregation of mass of degenerative material with membrane 
E)  None of the above 
A)  An irreversible aggregation of a mass of degenerative platelet material without membrane 
B)  A reversible aggregation of a mass of degenerative platelet material without membrane 
C)  Inhibition of the initial aggregation of platelets 
D)  Inhibition of an irreversible aggregation of mass of degenerative material with membrane 
E)  None of the above

Question 6

The intrinsic system of coagulation is measured by the __________.

Accepted Answer

A)  APTT 
B)  PT 
C)  Fibrinogen assay 
D)  TT 
E)  Reptilase time 
A)  APTT 
B)  PT 
C)  Fibrinogen assay 
D)  TT 
E)  Reptilase time

Question 7

Hemorrhaging from veins results in large, ill-defined, soft tissue bleeding termed __________.

Accepted Answer

A)  Petechiae 
B)  Ecchymoses 
C)  Epistaxis 
D)  All of the above 
E)  None of the above 
A)  Petechiae 
B)  Ecchymoses 
C)  Epistaxis 
D)  All of the above 
E)  None of the above

Question 8

What is the coagulation factor assigned as factor III?

Accepted Answer

A)  Tissue thromboplastin 
B)  Fibrinogen 
C)  Calcium 
D)  Christmas factor 
E)  None of the above 
A)  Tissue thromboplastin 
B)  Fibrinogen 
C)  Calcium 
D)  Christmas factor 
E)  None of the above

Question 9

What is the function of tissue plasminogen activator (TPA)?

Accepted Answer

A)  Inhibits platelet response 
B)  Activates plasmin to plasminogen and lyses the fibrin clot 
C)  Activates plasminogen to plasmin and lyses the fibrin clot 
D)  Stimulates antithrombin III 
E)  None of the above 
A)  Inhibits platelet response 
B)  Activates plasmin to plasminogen and lyses the fibrin clot 
C)  Activates plasminogen to plasmin and lyses the fibrin clot 
D)  Stimulates antithrombin III 
E)  None of the above

Question 10

All of the following are conditions in which the thrombin time is prolonged except:

Accepted Answer

A)  Circulating FDPs 
B)  Hypofibrinogenemia 
C)  Heparin therapy 
D)  Liver disease 
E)  Dysfibrinogenemia 
A)  Circulating FDPs 
B)  Hypofibrinogenemia 
C)  Heparin therapy 
D)  Liver disease 
E)  Dysfibrinogenemia

Question 11

Thrombin on the aggregated platelets surface converts __________ to fibrin.

Accepted Answer

A)  Fibrinogen 
B)  Plasmin 
C)  Prothrombin 
D)  Platelet factor III 
E)  None of the above 
A)  Fibrinogen 
B)  Plasmin 
C)  Prothrombin 
D)  Platelet factor III 
E)  None of the above

Question 12

All of the following are true regarding the secondary wave of aggregation except:

Accepted Answer

A)  It is dependent on the activation stimulus to evoke secretion of platelet granules. 
B)  It is an energy-dependent process. 
C)  It is a reversible process. 
D)  It is dependent on ADP, serotonin, and epinephrine. 
E)  None of the above is true. 
A)  It is dependent on the activation stimulus to evoke secretion of platelet granules. 
B)  It is an energy-dependent process. 
C)  It is a reversible process. 
D)  It is dependent on ADP, serotonin, and epinephrine. 
E)  None of the above is true.

Question 13

In the process of aggregation, fibrinogen binds to the calcium complex of platelet membrane __________.

Accepted Answer

A)  Glycoproteins Ib-IIIa 
B)  Glycoproteins IIb-IIIa 
C)  Glycoproteins Ib-IIa 
D)  Glycoproteins Ia-IIIa 
E)  None of the above 
A)  Glycoproteins Ib-IIIa 
B)  Glycoproteins IIb-IIIa 
C)  Glycoproteins Ib-IIa 
D)  Glycoproteins Ia-IIIa 
E)  None of the above

Exam 24: Introduction to Hemostasis

What is the function of thrombin?

The average diameter of the platelet is __________.

The physiologic process of removing unwanted fibrin deposits represents a gradual progressive enzymatic cleavage of fibrin to soluble fragments. This process is termed __________.

What is the coagulation factor assigned as factor VII?

What is meant by the term viscous metamorphosis?

The intrinsic system of coagulation is measured by the __________.

Hemorrhaging from veins results in large, ill-defined, soft tissue bleeding termed __________.

What is the coagulation factor assigned as factor III?

What is the function of tissue plasminogen activator (TPA)?

All of the following are conditions in which the thrombin time is prolonged except:

Thrombin on the aggregated platelets surface converts __________ to fibrin.

All of the following are true regarding the secondary wave of aggregation except:

In the process of aggregation, fibrinogen binds to the calcium complex of platelet membrane __________.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hemolytic Anemias: Extracorpuscular Defects

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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