Question 1

Which of the following antibodies do not cause a delayed hemolytic transfusion reaction?

Accepted Answer

A)  Anti-E 
B)  Anti-K 
C)  Anti-e 
D)  Anti-C 
E)  Anti-M 
A)  Anti-E 
B)  Anti-K 
C)  Anti-e 
D)  Anti-C 
E)  Anti-M

Question 2

Evaluate the course of infection that can occur in a splenectomized patient with babesiosis:

Accepted Answer

A)  Acute intravascular hemolysis 
B)  Hemoglobinemia 
C)  Renal failure 
D)  All of the above 
E)  None of the above 
A)  Acute intravascular hemolysis 
B)  Hemoglobinemia 
C)  Renal failure 
D)  All of the above 
E)  None of the above

Question 3

Anti-K was detected in a patient's serum 1 year ago in a routine antibody screen. This patient was transfused red cells containing antigen specific for anti-K. Forty-eight hours later the patient began exhibiting signs of a hemolytic anemia. What type of transfusion reaction is present?

Accepted Answer

A)  Delayed 
B)  Acute 
C)  Immediate 
D)  Allergic 
E)  Febrile 
A)  Delayed 
B)  Acute 
C)  Immediate 
D)  Allergic 
E)  Febrile

Question 4

A unit of blood transfused to a WAIHA patient should be:

Accepted Answer

A)  Least incompatible in the crossmatch 
B)  Negative for antigens for clinically significant antibodies present in the patient 
C)  Transfused slowly 
D)  Transfused in small volumes 
E)  All of the above 
A)  Least incompatible in the crossmatch 
B)  Negative for antigens for clinically significant antibodies present in the patient 
C)  Transfused slowly 
D)  Transfused in small volumes 
E)  All of the above

Question 5

A Donath-Landsteiner test is performed to determine the presence of antibodies with biphasic activity. The results show no hemolysis in the control sample and hemolysis in the test sample. These test results should be reported as:

Accepted Answer

A)  Positive 
B)  Negative 
C)  Inconclusive 
D)  Borderline 
E)  None of the above 
A)  Positive 
B)  Negative 
C)  Inconclusive 
D)  Borderline 
E)  None of the above

Question 6

Autoimmune hemolytic anemia represents an abnormality in which:

Accepted Answer

A)  Hemolysis results from antigen sensitization through blood transfusion. 
B)  Self-recognition of an individual's own red cell antigens is lost. 
C)  Hemolysis results from patient's antibodies binding to blood groups other than ABO. 
D)  Hemolysis is always drug induced. 
E)  All of the above 
A)  Hemolysis results from antigen sensitization through blood transfusion. 
B)  Self-recognition of an individual's own red cell antigens is lost. 
C)  Hemolysis results from patient's antibodies binding to blood groups other than ABO. 
D)  Hemolysis is always drug induced. 
E)  All of the above

Question 7

Which clinical feature suggests an acute hemolytic transfusion reaction?

Accepted Answer

A)  Fever 
B)  Chills 
C)  Hypotension 
D)  Nausea 
E)  All of the above 
A)  Fever 
B)  Chills 
C)  Hypotension 
D)  Nausea 
E)  All of the above

Question 8

Activation of the classical pathway is initiated by what immune complexes?

Accepted Answer

A)  IgG or IgM 
B)  IgM or IgA 
C)  IgE or IgM 
D)  IgD or IgE 
E)  IgG or IgA 
A)  IgG or IgM 
B)  IgM or IgA 
C)  IgE or IgM 
D)  IgD or IgE 
E)  IgG or IgA

Question 9

In alloimmune hemolytic anemia, hemolysis results from:

Accepted Answer

A)  Patient antibody to a foreign antigen coating the red cell 
B)  Patient antigen coating red cell 
C)  Patient antibody coating native red cell antigen 
D)  Drug in the patient serum coating red cells 
E)  None of the above 
A)  Patient antibody to a foreign antigen coating the red cell 
B)  Patient antigen coating red cell 
C)  Patient antibody coating native red cell antigen 
D)  Drug in the patient serum coating red cells 
E)  None of the above

Question 10

In two-thirds of cases of warm autoimmune hemolytic anemia (WAIHA), the direct antiglobulin test (DAT) will result in reactivity with:

Accepted Answer

A)  IgG only 
B)  IgG and C3d 
C)  C3d only 
D)  IgA 
E)  IgE 
A)  IgG only 
B)  IgG and C3d 
C)  C3d only 
D)  IgA 
E)  IgE

Question 11

Which of the following are classifications of immune hemolytic anemias?

Accepted Answer

A)  Alloimmune 
B)  Autoimmune 
C)  Drug-induced 
D)  All of the above 
E)  None of the above 
A)  Alloimmune 
B)  Autoimmune 
C)  Drug-induced 
D)  All of the above 
E)  None of the above

Exam 13: Hemolytic Anemias: Extracorpuscular Defects

Which of the following antibodies do not cause a delayed hemolytic transfusion reaction?

Evaluate the course of infection that can occur in a splenectomized patient with babesiosis:

Anti-K was detected in a patient's serum 1 year ago in a routine antibody screen. This patient was transfused red cells containing antigen specific for anti-K. Forty-eight hours later the patient began exhibiting signs of a hemolytic anemia. What type of transfusion reaction is present?

A unit of blood transfused to a WAIHA patient should be:

A Donath-Landsteiner test is performed to determine the presence of antibodies with biphasic activity. The results show no hemolysis in the control sample and hemolysis in the test sample. These test results should be reported as:

Autoimmune hemolytic anemia represents an abnormality in which:

Which clinical feature suggests an acute hemolytic transfusion reaction?

Activation of the classical pathway is initiated by what immune complexes?

In alloimmune hemolytic anemia, hemolysis results from:

In two-thirds of cases of warm autoimmune hemolytic anemia (WAIHA), the direct antiglobulin test (DAT) will result in reactivity with:

Which of the following are classifications of immune hemolytic anemias?

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

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Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

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Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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