Question 1

Chemicals or drugs that induce oxidative stress in red cells may result in hemoglobin being denatured and the formation of which type of inclusion?

Accepted Answer

A)  Hemoglobin H inclusions 
B)  Siderocytes 
C)  Howell-Jolly bodies 
D)  Heinz bodies 
E)  Pappenheimer bodies 
A)  Hemoglobin H inclusions 
B)  Siderocytes 
C)  Howell-Jolly bodies 
D)  Heinz bodies 
E)  Pappenheimer bodies

Question 2

To illustrate the presence of a malarial parasite in a blood smear, which stain is suggested?

Accepted Answer

A)  Methylene blue 
B)  Giemsa 
C)  Prussian blue 
D)  Eosin 
E)  Crystal violet 
A)  Methylene blue 
B)  Giemsa 
C)  Prussian blue 
D)  Eosin 
E)  Crystal violet

Question 3

Which is a characteristic red blood cell morphology in patients with abetalipoproteinemia?

Accepted Answer

A)  Acanthocytes 
B)  Target cells 
C)  Spherocytes 
D)  Helmet cells 
E)  None of the above 
A)  Acanthocytes 
B)  Target cells 
C)  Spherocytes 
D)  Helmet cells 
E)  None of the above

Question 4

The spherocyte is indicative of:

Accepted Answer

A)  Liver damage 
B)  Intravascular hemolysis 
C)  Extravascular hemolysis 
D)  Non-immune-mediated hemolysis 
E)  None of the above 
A)  Liver damage 
B)  Intravascular hemolysis 
C)  Extravascular hemolysis 
D)  Non-immune-mediated hemolysis 
E)  None of the above

Question 5

What type of transfusion reaction would result from an incompatible mismatch in the ABO blood group?

Accepted Answer

A)  Acute hemolytic 
B)  Hemolytic 
C)  Xenophobic 
D)  Delayed hemolytic 
E)  Allergic 
A)  Acute hemolytic 
B)  Hemolytic 
C)  Xenophobic 
D)  Delayed hemolytic 
E)  Allergic

Question 6

Complement is a group of serum proteins that interact with each other to bring about:

Accepted Answer

A)  Complement-independent cell-mediated lysis 
B)  Complement-dependent cell-mediated lysis 
C)  Antibody-independent cell-mediated lysis 
D)  Extravascular hemolysis 
E)  None of the above 
A)  Complement-independent cell-mediated lysis 
B)  Complement-dependent cell-mediated lysis 
C)  Antibody-independent cell-mediated lysis 
D)  Extravascular hemolysis 
E)  None of the above

Question 7

Warm autoimmune hemolytic anemia accounts for __________ of all cases of autoimmune hemolytic anemia.

Accepted Answer

A)  12% 
B)  70% 
C)  16% 
D)  4% 
E)  40% 
A)  12% 
B)  70% 
C)  16% 
D)  4% 
E)  40%

Question 8

What hemolytic anemia is a common occurrence in joggers and marathon runners?

Accepted Answer

A)  Cardiac prosthesis 
B)  March hemoglobinuria 
C)  Hemolytic uremia syndrome 
D)  Thrombotic thrombocytopenic purpura 
E)  Idiopathic thrombocytopenic purpura 
A)  Cardiac prosthesis 
B)  March hemoglobinuria 
C)  Hemolytic uremia syndrome 
D)  Thrombotic thrombocytopenic purpura 
E)  Idiopathic thrombocytopenic purpura

Question 9

Autoantibody in warm autoimmune hemolytic anemia (WAIHA) usually mimics __________ specifically.

Accepted Answer

A)  Rh 
B)  Lewis 
C)  Duffy 
D)  Kell 
E)  Kidd 
A)  Rh 
B)  Lewis 
C)  Duffy 
D)  Kell 
E)  Kidd

Question 10

Microangiopathic hemolytic anemia is usually characterized by the presence of:

Accepted Answer

A)  Schistocytes 
B)  Increased platelets 
C)  Leukocytosis 
D)  Normocytes 
E)  Target cells 
A)  Schistocytes 
B)  Increased platelets 
C)  Leukocytosis 
D)  Normocytes 
E)  Target cells

Question 11

Cold hemagglutinin disease represents __________ of all cases of autoimmune hemolytic anemia.

Accepted Answer

A)  70% 
B)  16% 
C)  2% 
D)  12% 
E)  50% 
A)  70% 
B)  16% 
C)  2% 
D)  12% 
E)  50%

Question 12

The peripheral blood smear of a patient with warm autoimmune hemolytic anemia will show:

Accepted Answer

A)  Marked polychromasia 
B)  Reticulocytosis 
C)  Spherocytosis 
D)  Red cell fragmentation 
E)  All of the above 
A)  Marked polychromasia 
B)  Reticulocytosis 
C)  Spherocytosis 
D)  Red cell fragmentation 
E)  All of the above

Question 13

Which of the following clinical features suggests a delayed hemolytic transfusion reaction has occurred?

Accepted Answer

A)  Mild fever 
B)  Mild jaundice 
C)  Unexpected fall in hemoglobin 
D)  All of the above 
E)  None of the above 
A)  Mild fever 
B)  Mild jaundice 
C)  Unexpected fall in hemoglobin 
D)  All of the above 
E)  None of the above

Question 14

In the case of partial phagocytosis, the red cell membrane reforms to form what type of red cell?

Accepted Answer

A)  Target cell 
B)  Spherocyte 
C)  Schistocyte 
D)  Macrocyte 
E)  Drepanocyte 
A)  Target cell 
B)  Spherocyte 
C)  Schistocyte 
D)  Macrocyte 
E)  Drepanocyte

Question 15

A drug mechanism that results in a positive DAT with IgG specificity and a reactive eluate that usually mimics anti-e specificity is:

Accepted Answer

A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune 
A)  Immune complex 
B)  Drug absorption 
C)  Membrane modification 
D)  Methyldopa-induced 
E)  Autoimmune

Question 16

Laboratory features that suggest paroxysmal cold hemoglobinuria include:

Accepted Answer

A)  Polychromasia 
B)  Poikilocytosis 
C)  Hemoglobinuria is present 
D)  Nucleated red blood cells 
E)  All of the above 
A)  Polychromasia 
B)  Poikilocytosis 
C)  Hemoglobinuria is present 
D)  Nucleated red blood cells 
E)  All of the above

Question 17

A patient received a blood transfusion that contained a foreign red cell antigen. The patient developed antibody to this foreign antigen. In this case a/an __________ response has occurred.

Accepted Answer

A)  Alloimmune 
B)  Autoimmune 
C)  Drug-induced 
D)  Non-immune 
E)  Allergic 
A)  Alloimmune 
B)  Autoimmune 
C)  Drug-induced 
D)  Non-immune 
E)  Allergic

Question 18

Plasmodium __________ has proven to be the most fatal of species of malaria presenting with massive intravascular hemolysis, jaundice, and hypotension.

Accepted Answer

A)  vivax 
B)  ovale 
C)  malariae 
D)  falciparum 
E)  hemolytica 
A)  vivax 
B)  ovale 
C)  malariae 
D)  falciparum 
E)  hemolytica

Question 19

Laboratory findings that support a diagnosis of a malaria infection include:

Accepted Answer

A)  Normochromic/normocytic anemia 
B)  Leukopenia 
C)  Thrombocytopenia 
D)  Presence of schizont on smear 
E)  All of the above 
A)  Normochromic/normocytic anemia 
B)  Leukopenia 
C)  Thrombocytopenia 
D)  Presence of schizont on smear 
E)  All of the above

Question 20

Intravascular hemolysis due to mechanical etiologies is usually accompanied by the presence of __________ on the peripheral blood smear.

Accepted Answer

A)  Schistocytes 
B)  Target cells 
C)  Sickle cells 
D)  Ovalocytes 
E)  Spherocytes 
A)  Schistocytes 
B)  Target cells 
C)  Sickle cells 
D)  Ovalocytes 
E)  Spherocytes

Exam 13: Hemolytic Anemias: Extracorpuscular Defects

Chemicals or drugs that induce oxidative stress in red cells may result in hemoglobin being denatured and the formation of which type of inclusion?

To illustrate the presence of a malarial parasite in a blood smear, which stain is suggested?

Which is a characteristic red blood cell morphology in patients with abetalipoproteinemia?

The spherocyte is indicative of:

What type of transfusion reaction would result from an incompatible mismatch in the ABO blood group?

Complement is a group of serum proteins that interact with each other to bring about:

Warm autoimmune hemolytic anemia accounts for __________ of all cases of autoimmune hemolytic anemia.

What hemolytic anemia is a common occurrence in joggers and marathon runners?

Autoantibody in warm autoimmune hemolytic anemia (WAIHA) usually mimics __________ specifically.

Microangiopathic hemolytic anemia is usually characterized by the presence of:

Cold hemagglutinin disease represents __________ of all cases of autoimmune hemolytic anemia.

The peripheral blood smear of a patient with warm autoimmune hemolytic anemia will show:

Which of the following clinical features suggests a delayed hemolytic transfusion reaction has occurred?

In the case of partial phagocytosis, the red cell membrane reforms to form what type of red cell?

A drug mechanism that results in a positive DAT with IgG specificity and a reactive eluate that usually mimics anti-e specificity is:

Laboratory features that suggest paroxysmal cold hemoglobinuria include:

A patient received a blood transfusion that contained a foreign red cell antigen. The patient developed antibody to this foreign antigen. In this case a/an __________ response has occurred.

Plasmodium __________ has proven to be the most fatal of species of malaria presenting with massive intravascular hemolysis, jaundice, and hypotension.

Laboratory findings that support a diagnosis of a malaria infection include:

Intravascular hemolysis due to mechanical etiologies is usually accompanied by the presence of __________ on the peripheral blood smear.

Morphology of Human Blood and Marrow Cells: Hematopoiesis

Bone Marrow

The Red Blood Cell: Structure and Function

Anemia: Diagnosis and Clinical Considerations

Evaluation of Red Blood Cell Morphology and Introduction to Platelet and White Blood Cell Morphology

Iron Metabolism and Hypochromic Anemias

Megaloblastic Anemias

Aplastic Anemia Including Pure Red Cell Aplasia and Congenital Dyserythropoietic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Introduction to Hemolytic Anemias: Intracorpuscular Defects: I Hereditary Defects of the Red Cell Membrane

Hemolytic Anemias: Intracorpuscular Defects: II Hereditary Enzyme Deficiencies

Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Hemolytic Anemias: Intracorpuscular Defects: Iv Thalassemia

Hypoproliferative Anemia: Anemia Associated With Systemic Diseases

Cell Biology, Disorders of Neutrophils, Infectious Mononucleosis, and Reactive Lymphocytosis

Introduction to Leukemia and the Acute Leukemias

Chronic Myeloproliferative Disorders I: Chronic Myelogenous Leukemia

Chronic Myeloproliferative Disorders Ii: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis

Myelodysplastic Syndromes

Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders

The Lymphomas

Multiple Myeloma and Related Plasma Cell Disorders

Lipid Lysosomal Storage Diseases and Histiocytosis

Introduction to Hemostasis

Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders

Disorders of Plasma Clotting Factors

Interaction of the Fibrinolytic, Coagulation, and Kinin Systems; Disseminated Intravascular Coagulation; and Related Pathology

Introduction to Thrombosis and Anticoagulant Therapy

Quality Control in the Hematology Laboratory

Body Fluid Examination: the Qualitative, Quantitative, and Morphologic Analysis of Serous, Cerebrospinal, and Synovial Fluids

Hematology Methods

Principles of Automated Differential Analysis

Coagulation Procedures

Applications of Flow Cytometry to Hematology and Hemostasis

Molecular Diagnostic Techniques in Hematopathology

Special Stainscytochemistry

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