Exam 12: Psychomotor Stimulants: Cocaine, Amphetamine, and Related Drugs

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What is the minimum dopamine transporter (DAT) occupancy required to achieve a "high" from either cocaine or methylphenidate, based on imaging studies?

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List several members of the amphetamine family of drugs. How are their chemical structures similar? Identify two such compounds that occur in nature. How have amphetamines been used to treat diseases and enhance daily functioning, prior to governmental restriction?

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Members of the amphetamine family include amphetamine, methamphetamine, cathinone, and ephedrine, which all are structurally related to dopamine. Cathinone and ephedrine occur in nature. Historically, members of the amphetamine family have been used for weight loss, treatment of asthma (as a constituent of inhalers), treatment of narcolepsy, and to maintain alertness (e.g., by military personnel).

Which statement about cocaine administration and absorption is true?

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Mephedrone, methylone, MDPV, and α-PVP are all members of the class of

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If someone who has taken cocaine is exhibiting _______ you would expect that they have been taking high _______ doses of the drug.

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The precondition of _______ would make heavy amphetamine use particularly dangerous.

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In mice, _______ receptor agonists were shown to reduce the locomotor activity effects of cocaine, while, _______ receptor agonists increased locomotor activity.

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Compare methamphetamine with amphetamine in terms of route of administration, potency, effects at the synapse, psychological effects, and neurotoxicity.

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Which statement about cocaine is true?

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Amphetamines have been medically prescribed for narcolepsy and weight loss but have largely been replaced with alternative drugs because

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Which statement concerning the receptor subtypes involved in psychostimulant effects is true?

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Identify the various routes of administration for cocaine. Which routes of administration yield the most rapid absorption of cocaine? Identify two metabolites of cocaine use; one found after use of cocaine alone and the other found after using a combination cocaine and alcohol.

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An early use of amphetamine was as a

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List several effects of cocaine that occur at low to moderate doses. Which of these effects are considered to be part of the cocaine "high"? Identify several aversive effects that occur in high dose users.

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Cocaine acts in the nervous system by blocking _______ and voltage-gated _______ channels.

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According to imaging studies of human brains, which three factors influence the occurrence and intensity of a cocaine or methylphenidate "high"?

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Repeated exposure to cocaine and other psychostimulants

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Describe the effects of cocaine at the synapse in detail. What specific effects are most important for cocaine's reinforcing and addictive characteristics? What effects of cocaine are responsible for its action as a local anesthetic?

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Amphetamines increase catecholamine release in part by

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Which statement about U.S. cocaine use trends between 2014 and 2018 is true?

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